Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Adipose-derived stem cells (1)
- And collagen type I (1)
- Biodistribution (1)
- Bioprinting; Data science; Tissue engineering; Computer vision; Nerve regeneration; Machine learning; Artificial intelligence; ACCELERATES AXON REGENERATION; PERIPHERAL-NERVE; SCHWANN-CELLS; ELECTRICAL-STIMULATION; GROWTH-FACTOR; GENE-THERAPY; NEUROTROPHIC FACTOR; GUIDANCE CHANNELS; NEURAL-NETWORK; SCIATIC-NERVE (1)
- Biosensors (1)
-
- Breast cancer (1)
- Cancer diagnostics (1)
- Cancer therapeutics (1)
- Cataract (1)
- Co-culture (1)
- Drug delivery (1)
- Extracellular matrix (1)
- Fibrosis (1)
- Hsp27 (1)
- Image processing (1)
- Lignin (1)
- Lutein (1)
- Methacrylated gelatin (1)
- Microfluidic devices (1)
- Multiple myeloma (1)
- Nanoparticle (1)
- Nanoparticles (1)
- Ocular (1)
- Plasmonics (1)
- Point-of-care devices (1)
- Poly(ethylene glycol) (1)
- Single cell analysis (1)
- Stromal signaling (1)
- Tumor (1)
- Publication Type
Articles 1 - 6 of 6
Full-Text Articles in Engineering
Incorporation Of Lignin In Natural And Synthetic Biomaterials To Alter Mechanical And Biochemical Properties For Enhanced Wound Healing, Jorge Alfonso Belgodere
Incorporation Of Lignin In Natural And Synthetic Biomaterials To Alter Mechanical And Biochemical Properties For Enhanced Wound Healing, Jorge Alfonso Belgodere
LSU Doctoral Dissertations
It is estimated that chronic, non-healing wounds affect more than 6.5 million Americans annually, with an estimated healthcare cost beyond $14 billion. Here, we attempted to create composites of natural (collagen type I or gelatin-methacrylate) or synthetic (poly(ethylene glycol) polymers incorporating a natural plant component, lignin, to combat the costs and limitations current wound healing methods face. Three-dimensional matrices of collagen type I (Col I) are widely used in tissue engineering applications for its abundance in many tissues, bioactivity with many cell types, and excellent biocompatibility. Inspired by the structural role of lignin in plant tissue, we found that sodium …
Characterizing The Biophysical Properties And Origin Of Extracellular Matrix In The Breast Tumor Microenvironment, Connor T. King
Characterizing The Biophysical Properties And Origin Of Extracellular Matrix In The Breast Tumor Microenvironment, Connor T. King
LSU Master's Theses
Tumors derived from breast tissue possess the ability to manipulate and permanently alter their surrounding tissue. Studies demonstrate that tissues surrounding breast tumors have differences in secreted factors as well as extracellular matrix (ECM) deposition and structure. However, some fundamental gaps exist within this paradigm: specifically, what exacerbates this transformation and are these changes maintained between the subtypes of breast tumors? Therefore, a targeted evaluation of the effects of the tumor on the stromal microenvironment in a subtype specific manner will be invaluable. To determine if tumor aggressiveness and subtype differentially regulate the tumor microenvironment, a model must be constructed …
Point-Of-Care Devices For Therapeutic, Medical And Environmental Applications, Alisha Prasad
Point-Of-Care Devices For Therapeutic, Medical And Environmental Applications, Alisha Prasad
LSU Doctoral Dissertations
Point-of-care testing (POCT) or Point-of-use (POU) devices or technologies are defined as testing aids that are capable for onsite use or testing. The key advantages of POCT are low sample volume, quick onsite diagnosis, high accuracy, and cost-effectiveness. POCT has the potential and the benefits to facilitate better health care management by rapid routine diagnosis and monitoring. To reach this goal, several researchers as well as the healthcare industry over a few years have conducted cutting edge research to bring science to technology by developing smart diagnostic devices capable of performing as per patient profiles and make personalized health care …
Machine Intelligence For Nerve Conduit Design And Production, Caleb E. Stewart, Chin Fung Kelvin Kan, Brody R. Stewart, Henry W. Sanicola Iii, Jangwook P. Jung, Olawale A. R. Sulaiman, Dadong Wang
Machine Intelligence For Nerve Conduit Design And Production, Caleb E. Stewart, Chin Fung Kelvin Kan, Brody R. Stewart, Henry W. Sanicola Iii, Jangwook P. Jung, Olawale A. R. Sulaiman, Dadong Wang
Faculty Publications
Nerve guidance conduits (NGCs) have emerged from recent advances within tissue engineering as a promising alternative to autografts for peripheral nerve repair. NGCs are tubular structures with engineered biomaterials, which guide axonal regeneration from the injured proximal nerve to the distal stump. NGC design can synergistically combine multiple properties to enhance proliferation of stem and neuronal cells, improve nerve migration, attenuate inflammation and reduce scar tissue formation. The aim of most laboratories fabricating NGCs is the development of an automated process that incorporates patient-specific features and complex tissue blueprints (e.g. neurovascular conduit) that serve as the basis for more complicated …
Polymeric Nanoparticles As An Antioxidant Delivery System For Age-Related Eye Disease, Sean M. Swetledge
Polymeric Nanoparticles As An Antioxidant Delivery System For Age-Related Eye Disease, Sean M. Swetledge
LSU Doctoral Dissertations
Advantages of polymeric nanoparticles as ocular drug delivery systems include controlled release, enhanced drug stability and bioavailability, and specific tissue targeting. Nanoparticle properties such as hydrophobicity, size, and charge, mucoadhesion, as well as administration route and suspension media affect their ability to overcome ocular barriers and distribute in the eye, and must be carefully designed for specific target tissues and ocular diseases. A review was conducted to serve as a guide to optimizing polymeric nanoparticle delivery systems for ocular drug delivery by discussing the effects of nanoparticle composition and administration method on their ocular penetration, distribution, elimination, toxicity, and efficacy, …
Experimental And Computational Tools For Single Cell Analysis In Cancer Diagnostics, Manibarathi Vaithiyanathan
Experimental And Computational Tools For Single Cell Analysis In Cancer Diagnostics, Manibarathi Vaithiyanathan
LSU Doctoral Dissertations
Substantial evidence shows that cellular heterogeneity commonly exists within an isogenic or clonal population. Whether in isolation or caused through a combination of the above events, cellular heterogeneity can dramatically influence cellular decision making and cell fate, however, this can be masked by the average response from a population. One approach to solve this issue is to analyze a population at the individual cell level. The goal of this work is to develop high-throughput experimental and computational platforms to screen and quantify single cancer cells for specific intracellular enzyme activities. An interdisciplinary approach was taken to 1) better understand the …