Engineering Commons^™

68ga-Nota-Chsg And 99mtc-Chsg Labeled Microspheres For Lung Perfusion And Liver Radiomicrospheres Therapy Planning, Alejandro Amor-Coarasa, Andrew Milera, Denny Carvajal, Seza Gulec, Jared Leichner, Anthony J. Mcgoron

Department of Biomedical Engineering Faculty Publications

Fast biodegradable (12 h < half-life < 48 h) radioactive labeled microspheres are needed for PET and SPECT lung perfusion and radiomicrosphere therapy planning. An emulsion method was used to create 30.1 ±4.8 μm size range microspheres with biodegradable Chitosan glycol (CHSg). Microspheres were characterized and labeled with or as an alternative to MAA in perfusion PET and SPECT studies. Surface decoration of CHSg microspheres with p-SCN-Bn-NOTA was performed to increase   in vivo stability. was labeled directly to the CHSg microspheres. Labeling yield and in vitro radiochemical stability were evaluated. In vitro CHSg microsphere degradation half-life was ~24 hours in porcine blood. Labeled microspheres were injected into Sprague Dawley rats and biodistribution was determined after 2 and 4 hours. Both -CHSg and -NOTA-CHSg were quickly allocated in the lungs after injection. -CHSg showed 91.6 ± 6.5% and 83.2 ± 4.1% of the decay corrected injected activity remaining in the lungs after 2 and 4 hours, respectively. For the obtained -NOTA-CHSg microspheres, lung allocation was very high with 98.9 ± 0.2% and 95.6 ± 0.9% after 2 and 4 hours, respectively. The addition of p-SCN-Bn-NOTA acts as a radioprotectant eliminating the released activity from the lungs to the bladder protecting the other organs.

Fabrication And Characterization Of Sno2/Graphene Composites As High Capacity Anodes For Li-Ion Batteries, Abirami Dhanabalan, Xifei Li, Richa Agrawal, Chunhui Chen

Department of Mechanical and Materials Engineering

Tin-oxide and graphene (TG) composites were fabricated using the Electrostatic Spray Deposition (ESD) technique, and tested as anode materials for Li-ion batteries. The electrochemical performance of the as-deposited TG composites were compared to heat-treated TG composites along with pure tin-oxide films. The heat-treated composites exhibited superior specific capacity and energy density than both the as-deposited TG composites and tin oxide samples. At the 70th cycle, the specific capacities of the as-deposited and post heat-treated samples were 534 and 737 mA·h/g, respectively, and the corresponding energy densities of the as-deposited and heat-treated composites were 1240 and 1760 W·h/kg, respectively. This improvement …

Development Of An Enhanced Hydro-Geochemical Model To Address Mercury-Speciation Fate And Transport In Aquatic Environments, Nantaporn Noosai

FIU Electronic Theses and Dissertations

An awareness of mercury (Hg) contamination in various aquatic environments around the world has increased over the past decade, mostly due to its ability to concentrate in the biota. Because the presence and distribution of Hg in aquatic systems depend on many factors (e.g., pe, pH, salinity, temperature, organic and inorganic ligands, sorbents, etc.), it is crucial to understand its fate and transport in the presence of complexing constituents and natural sorbents, under those different factors. An improved understanding of the subject will support the selection of monitoring, remediation, and restoration technologies.

The coupling of equilibrium chemical reactions with transport …

Implementing The Surface Response To Excitation Method (Sure) With Non-Contact Sensors, Sergio R. Gonzalez Jr.

FIU Electronic Theses and Dissertations

Structural health monitoring (SHM) systems generally install low cost excitation component and/or sensors to the machines or buildings permanently to monitor the health of it. Non Destructive Evaluation (NDE) systems use high cost sensors to perform the inspection of structures. It would be advantageous to inspect the some aerospace structures and parts in vacuum environment by using the remotely monitoring systems such as laser vibrometer. In this study, a scanning laser vibrometer is used to detect the location of the problem at the structure. For data collection and analysis recently, developed surface response to excitation (SuRE) method was used.

First …

Modeling, Simulation, And Characterization Of Space Debris In Low-Earth Orbit, Paul D. Mccall

FIU Electronic Theses and Dissertations

Every space launch increases the overall amount of space debris. Satellites have limited awareness of nearby objects that might pose a collision hazard. Astrometric, radiometric, and thermal models for the study of space debris in low-Earth orbit have been developed. This modeled approach proposes analysis methods that provide increased Local Area Awareness for satellites in low-Earth and geostationary orbit. Local Area Awareness is defined as the ability to detect, characterize, and extract useful information regarding resident space objects as they move through the space environment surrounding a spacecraft.

The study of space debris is of critical importance to all space-faring …

Development Of A Coupling Model For Fluid-Structure Interaction Using The Mesh-Free Finite Element Method And The Lattice Boltzmann Method, Jaime Mudrich

FIU Electronic Theses and Dissertations

In the presented thesis work, the meshfree method with distance fields was coupled with the lattice Boltzmann method to obtain solutions of fluid-structure interaction problems. The thesis work involved development and implementation of numerical algorithms, data structure, and software. Numerical and computational properties of the coupling algorithm combining the meshfree method with distance fields and the lattice Boltzmann method were investigated. Convergence and accuracy of the methodology was validated by analytical solutions.

The research was focused on fluid-structure interaction solutions in complex, mesh-resistant domains as both the lattice Boltzmann method and the meshfree method with distance fields are particularly adept …

Towards The Prediction Of Mutations In Genomic Sequences, Juan Carlos Martinez

FIU Electronic Theses and Dissertations

Bio-systems are inherently complex information processing systems. Furthermore, physiological complexities of biological systems limit the formation of a hypothesis in terms of behavior and the ability to test hypothesis. More importantly the identification and classification of mutation in patients are centric topics in today’s cancer research.

Next generation sequencing (NGS) technologies can provide genome-wide coverage at a single nucleotide resolution and at reasonable speed and cost. The unprecedented molecular characterization provided by NGS offers the potential for an individualized approach to treatment. These advances in cancer genomics have enabled scientists to interrogate cancer-specific genomic variants and compare them with the …

A Novel Signal Processing Method For Intraoperative Neurophysiological Monitoring In Spinal Surgeries, Krishnatej Vedala

FIU Electronic Theses and Dissertations

Intraoperative neurophysiologic monitoring is an integral part of spinal surgeries and involves the recording of somatosensory evoked potentials (SSEP). However, clinical application of IONM still requires anywhere between 200 to 2000 trials to obtain an SSEP signal, which is excessive and introduces a significant delay during surgery to detect a possible neurological damage. The aim of this study is to develop a means to obtain the SSEP using a much less, twelve number of recordings. The preliminary step involved was to distinguish the SSEP with the ongoing brain activity. We first establish that the brain activity is indeed quasi-stationary whereas …

Development Of A Body For A Pneumatic Crawler For Radioactive Waste Pipelines, Jose Alfonso Matos

FIU Electronic Theses and Dissertations

The goal of this thesis was to develop a body for a crawler robot to navigate DOE Hanford Site transfer pipelines in a timely fashion. Previous work in pipe crawlers was analyzed and different configurations were studied by this author in order to design a suitable device. Tests were done in CAD to verify the device would fit and be able to travel within the confines of the pipelines’3” inner diameter and 90° elbows with 4.25”radii. Pipelines in Hanford can transition into 2” pipe and this was also taken into consideration when selecting the dimensions for the device. Manufacturing methods …

Xpswmm Analysis Of The Ornl Stormwater Collection System Up To Outfall 211, Heidi Belle Henderson

FIU Electronic Theses and Dissertations

The Oak Ridge National Laboratory, Tennessee, was the site for a number of US Government projects during the 1940s and 1950s including the development of thermonuclear weapons. Chemical processes conducted at the site as part of these projects resulted in contamination of certain building areas at the ORNL. The purpose of this study is to develop a hydraulic-hydrologic computer model via XPSWMM to determine surface water flow rates and water stages within the drainage system during rainfall events and introduce a conservative contaminant into the system to trace peak concentrations of contaminants.

The model was calibrated by simulating actual rainfall …

A Generalized Adaptive Mathematical Morphological Filter For Lidar Data, Zheng Cui

FIU Electronic Theses and Dissertations

Airborne Light Detection and Ranging (LIDAR) technology has become the primary method to derive high-resolution Digital Terrain Models (DTMs), which are essential for studying Earth’s surface processes, such as flooding and landslides. The critical step in generating a DTM is to separate ground and non-ground measurements in a voluminous point LIDAR dataset, using a filter, because the DTM is created by interpolating ground points. As one of widely used filtering methods, the progressive morphological (PM) filter has the advantages of classifying the LIDAR data at the point level, a linear computational complexity, and preserving the geometric shapes of terrain features. …

Network Construction And Graph Theoretical Analysis Of Functional Language Networks In Pediatric Epilepsy, Anas Salah Eddin

FIU Electronic Theses and Dissertations

This dissertation introduces a new approach for assessing the effects of pediatric epilepsy on the language connectome. Two novel data-driven network construction approaches are presented. These methods rely on connecting different brain regions using either extent or intensity of language related activations as identified by independent component analysis of fMRI data. An auditory description decision task (ADDT) paradigm was used to activate the language network for 29 patients and 30 controls recruited from three major pediatric hospitals. Empirical evaluations illustrated that pediatric epilepsy can cause, or is associated with, a network efficiency reduction. Patients showed a propensity to inefficiently employ …

Novel Online Data Cleaning Protocols For Data Streams In Trajectory, Wireless Sensor Networks, Sitthapon Pumpichet

FIU Electronic Theses and Dissertations

The promise of Wireless Sensor Networks (WSNs) is the autonomous collaboration of a collection of sensors to accomplish some specific goals which a single sensor cannot offer. Basically, sensor networking serves a range of applications by providing the raw data as fundamentals for further analyses and actions. The imprecision of the collected data could tremendously mislead the decision-making process of sensor-based applications, resulting in an ineffectiveness or failure of the application objectives. Due to inherent WSN characteristics normally spoiling the raw sensor readings, many research efforts attempt to improve the accuracy of the corrupted or “dirty” sensor data. The dirty …

Real-Time Biosensor For The Assessment Of Nanotoxicity And Cancer Electrotherapy, Evangelia Hondroulis

FIU Electronic Theses and Dissertations

Knowledge of cell electronics has led to their integration to medicine either by physically interfacing electronic devices with biological systems or by using electronics for both detection and characterization of biological materials. In this dissertation, an electrical impedance sensor (EIS) was used to measure the electrode surface impedance changes from cell samples of human and environmental toxicity of nanoscale materials in 2D and 3D cell culture models. The impedimetric response of human lung fibroblasts and rainbow trout gill epithelial cells when exposed to various nanomaterials was tested to determine their kinetic effects towards the cells and to demonstrate the biosensor’s …

Field Development And Performance Evaluation Of A Constructed Wetland System In The Tropics, Adelaide Pereira Hummel

FIU Electronic Theses and Dissertations

This study is part of a project that was conducted by Florida International University (FIU), which designed, built, and characterized a constructed wetland (CW) wastewater treatment system in El Salvador, Central America. This study focuses on the detailed performance of a field-scale CW in the tropics, consisting of a subsurface flow wetland (SSF) and a surface flow wetland (SF). The SSF had a total area of 151.2 sq. m., filled with gravel and planted with Phragmites, Thalia, and Brachiaria, along three independent cells operating with a flow in parallel and receiving the influent domestic wastewater from a …

Development Of Effective Approaches To The Large-Scale Aerodynamic Testing Of Low-Rise Building, Tuan-Chun Fu

FIU Electronic Theses and Dissertations

Low-rise buildings are often subjected to high wind loads during hurricanes that lead to severe damage and cause water intrusion. It is therefore important to estimate accurate wind pressures for design purposes to reduce losses. Wind loads on low-rise buildings can differ significantly depending upon the laboratory in which they were measured. The differences are due in large part to inadequate simulations of the low-frequency content of atmospheric velocity fluctuations in the laboratory and to the small scale of the models used for the measurements. A new partial turbulence simulation methodology was developed for simulating the effect of low-frequency flow …

A Decision Support Framework For Infrastructure Maintenance Investment Decision-Making, Farrukh Arif

FIU Electronic Theses and Dissertations

Infrastructure management agencies are facing multiple challenges, including aging infrastructure, reduction in capacity of existing infrastructure, and availability of limited funds. Therefore, decision makers are required to think innovatively and develop inventive ways of using available funds. Maintenance investment decisions are generally made based on physical condition only. It is important to understand that spending money on public infrastructure is synonymous with spending money on people themselves. This also requires consideration of decision parameters, in addition to physical condition, such as strategic importance, socioeconomic contribution and infrastructure utilization. Consideration of multiple decision parameters for infrastructure maintenance investments can be beneficial …

Synthesis Of Carbon Nanotubes Using High Voltage And High Frequency Induction Field, Kalty Vazquez

FIU Electronic Theses and Dissertations

The fields of nanomaterial and nanostructures are some of the fastest growing fields in material science today. Carbon nanotubes are at the forefront of these fields and their unique mechanical and electrical properties are of great interest to those working in multiple engineering fields.

The overall objective of this study was to design and develop a new process and the equipment necessary, to synthesize carbon nanotubes using high voltage and a high-frequency induction field. This was the first time that a high voltage and an induction field have been used simultaneously in high yield production of carbon nanotubes.

The source …

Trajectory Privacy Preservation In Mobile Wireless Sensor Networks, Xinyu Jin

FIU Electronic Theses and Dissertations

In recent years, there has been an enormous growth of location-aware devices, such as GPS embedded cell phones, mobile sensors and radio-frequency identification tags. The age of combining sensing, processing and communication in one device, gives rise to a vast number of applications leading to endless possibilities and a realization of mobile Wireless Sensor Network (mWSN) applications. As computing, sensing and communication become more ubiquitous, trajectory privacy becomes a critical piece of information and an important factor for commercial success. While on the move, sensor nodes continuously transmit data streams of sensed values and spatiotemporal information, known as ``trajectory information". …

Clean Hydrogen Production And Carbon Dioxide Capture Methods, Sushant Kumar

FIU Electronic Theses and Dissertations

Fossil fuels constitute a significant fraction of the world’s energy demand. The burning of fossil fuels emits huge amounts of carbon dioxide into the atmosphere. Therefore, the limited availability of fossil fuel resources and the environmental impact of their use require a change to alternative energy sources or carriers (such as hydrogen) in the foreseeable future. The development of methods to mitigate carbon dioxide emission into the atmosphere is equally important. Hence, extensive research has been carried out on the development of cost-effective technologies for carbon dioxide capture and techniques to establish hydrogen economy.

Hydrogen is a clean energy fuel …

Bionano Electronics: Magneto-Electric Nanoparticles For Drug Delivery, Brain Stimulation And Imaging Applications, Rakesh Guduru

FIU Electronic Theses and Dissertations

Nanoparticles are often considered as efficient drug delivery vehicles for precisely dispensing the therapeutic payloads specifically to the diseased sites in the patient’s body, thereby minimizing the toxic side effects of the payloads on the healthy tissue. However, the fundamental physics that underlies the nanoparticles’ intrinsic interaction with the surrounding cells is inadequately elucidated. The ability of the nanoparticles to precisely control the release of its payloads externally (on-demand) without depending on the physiological conditions of the target sites has the potential to enable patient- and disease-specific nanomedicine, also known as Personalized NanoMedicine (PNM). In this dissertation, magneto-electric nanoparticles (MENs) …

Tubular And Sector Heat Pipes With Interconnected Branches For Gas Turbine And/Or Compressor Cooling, Brian D. Reding Ii

FIU Electronic Theses and Dissertations

Designing turbines for either aerospace or power production is a daunting task for any heat transfer scientist or engineer. Turbine designers are continuously pursuing better ways to convert the stored chemical energy in the fuel into useful work with maximum efficiency. Based on thermodynamic principles, one way to improve thermal efficiency is to increase the turbine inlet pressure and temperature. Generally, the inlet temperature may exceed the capabilities of standard materials for safe and long-life operation of the turbine. Next generation propulsion systems, whether for new supersonic transport or for improving existing aviation transport, will require more aggressive cooling system …

Fabrication Of Dense Non-Circular Nanomagnetic Device Arrays Using Self-Limiting Low-Energy Glow-Discharge Processing, Zhen Zheng, Long Chang, Ivan Nekrashevich, Paul Ruchhoeft, Sakhrat Khizroev, Dmitri Litvinov

Electrical and Computer Engineering Faculty Publications

We describe a low-energy glow-discharge process using reactive ion etching system that enables non-circular device patterns, such as squares or hexagons, to be formed from a precursor array of uniform circular openings in polymethyl methacrylate, PMMA, defined by electron beam lithography. This technique is of a particular interest for bit-patterned magnetic recording medium fabrication, where close packed square magnetic bits may improve its recording performance. The process and results of generating close packed square patterns by self-limiting low-energy glow-discharge are investigated. Dense magnetic arrays formed by electrochemical deposition of nickel over self-limiting formed molds are demonstrated.

The Role Of Complementary And Alternative Medicine In Regenerative Medicine, Yueh-Sheng Chen, Wei-Chiang Lin, Cheryl Miller

Department of Biomedical Engineering Faculty Publications

No abstract provided.

Site Specifc Growth Of Metal Catalyzed Silica Nanowires For Biological And Chemical Sensing, Eric G. Huey

FIU Electronic Theses and Dissertations

In this research the integration of nanostructures and micro-scale devices was investigated using silica nanowires to develop a simple yet robust nanomanufacturing technique for improving the detection parameters of chemical and biological sensors. This has been achieved with the use of a dielectric barrier layer, to restrict nanowire growth to site-specific locations which has removed the need for post growth processing, by making it possible to place nanostructures on pre-pattern substrates. Nanowires were synthesized using the Vapor-Liquid-Solid growth method. Process parameters (temperature and time) and manufacturing aspects (structural integrity and biocompatibility) were investigated.

Silica nanowires were observed experimentally to determine …

Climate, Land Use And Hydrologic Sensitivities Of Stormwater Quantity And Quality In Complex Coastal Urban Watersheds, Shams Al-Amin

FIU Electronic Theses and Dissertations

The study analyzed hydro-climatic and land use sensitivities of stormwater runoff and quality in the complex coastal urban watershed of Miami River Basin, Florida by developing a Storm Water Management Model (EPA SWMM 5). Regression-based empirical models were also developed to explain stream water quality in relation to internal (land uses and hydrology) and external (upstream contribution, seawater) sources and drivers in six highly urbanized canal basins of Southeast Florida. Stormwater runoff and quality were most sensitive to rainfall, imperviousness, and conversion of open lands/parks to residential, commercial and industrial areas. In-stream dissolved oxygen and total phosphorus in the watersheds …

Meshfree Method For Prediction Of Thermal Properties Of Porous Ceramic Materials, Maryam Zahedi

FIU Electronic Theses and Dissertations

In the presented thesis work, meshfree method with distance fields is applied to create a novel computational approach which enables inclusion of the realistic geometric models of the microstructure and liberates Finite Element Analysis(FEA) from the
dependance on and limitations of meshing of fine microstructural feature such as splats and porosity.
Manufacturing processes of ceramics produce materials with complex porosity microstructure.Geometry of pores, their size and location substantially affect macro scale physical properties of the material. Complex structure and geometry of the pores severely limit application of modern Finite Element Analysis methods because they require construction of spatial grids (meshes) …

Integration Of A Sedimentation Module To A Hydrologic Model And Its Application To A Mercury Tmdl Analysis, Lilian Marrero

FIU Electronic Theses and Dissertations

This research is part of continued efforts to correlate the hydrology of East Fork Poplar Creek (EFPC) and Bear Creek (BC) with the long term distribution of mercury within the overland, subsurface, and river sub-domains. The main objective of this study was to add a sedimentation module (ECO Lab) capable of simulating the reactive transport mercury exchange mechanisms within sediments and porewater throughout the watershed. The enhanced model was then applied to a Total Maximum Daily Load (TMDL) mercury analysis for EFPC. That application used historical precipitation, groundwater levels, river discharges, and mercury concentrations data that were retrieved from government …

Reducing Uncertainties In Estimation Of Wind Effects On Tall Buildings Using Aerodynamic Wind Tunnel Tests, Workamaw Paulos Warsido

FIU Electronic Theses and Dissertations

Tall buildings are wind-sensitive structures and could experience high wind-induced effects. Aerodynamic boundary layer wind tunnel testing has been the most commonly used method for estimating wind effects on tall buildings. Design wind effects on tall buildings are estimated through analytical processing of the data obtained from aerodynamic wind tunnel tests. Even though it is widely agreed that the data obtained from wind tunnel testing is fairly reliable the post-test analytical procedures are still argued to have remarkable uncertainties. This research work attempted to assess the uncertainties occurring at different stages of the post-test analytical procedures in detail and suggest …

Enhanced 3-Dimensional Carbon Nanotube Based Anodes For Li-Ion Battery Applications, Chi Won Kang

FIU Electronic Theses and Dissertations

A prototype 3-dimensional (3D) anode, based on multiwall carbon nanotubes (MWCNTs), for Li-ion batteries (LIBs), with potential use in Electric Vehicles (EVs) was investigated. The unique 3D design of the anode allowed much higher areal mass density of MWCNTs as active materials, resulting in more amount of Li⁺ ion intake, compared to that of a conventional 2D counterpart. Furthermore, 3D amorphous Si/MWCNTs hybrid structure offered enhancement in electrochemical response (specific capacity 549 mAhg^-1). Also, an anode stack was fabricated to further increase the areal or volumetric mass density of MWCNTs. An areal mass density of the anode …