Engineering Commons^™

Tumor Detection And Treatment By Means Of Thermography And Laser Irradiation, Euiheon Chung, Gyungseok Oh, Su Woong Yoo

Advances in Optics for Biotechnology, Medicine and Surgery XV

While passive thermal imaging of temperature difference between tumor and neighboring tissue provides limited contrast, active thermography with external thermal modulation may provide higher contrast presumably due to the distinct thermal response from the tumor tissue. We have investigated physiologically relevant parameters such as response rate with respect to thermal modulation and relaxation time. This new imaging modality in the infrared regime may prove useful as a label-free and non-invasive screening tool. On the other hand, we propose a novel use of controlled thermal injury from non-ablative fractional laser irradiation for early treatment of tumor growth with a fiber-based thulium …

Compact Cell Culture Imaging System Using Fourier Ptychographic Microscopy, Daniel Martin, Jinho Kim, Changhuei Yang

Advances in Optics for Biotechnology, Medicine and Surgery XV

The ability to obtain image data of multiple cell cultures simultaneously over a long-term period can provide researchers with a wealth of information. However, commercial systems rely on conventional microscopes, which are limited by their space-bandwidth product (SBP) [1]. Additionally, existing solutions that address the SBP limitation, are not conducive to well-plate imaging, which are an in-vitro culturing standard [2]. Using the benefits of Fourier ptychographic microscopy (FPM), these physical limitations can be transformed into problems that can be solved in the digital domain [3]. Our lab has demonstrated a compact, six-well plate imaging system, which is small enough to …

Frequency Domain Diffuse Optical Tomography With A Single Source And Detector Via High- Speed Hypocycloid Scanning, Matthew B. Applegate, Darren Roblyer

Advances in Optics for Biotechnology, Medicine and Surgery XV

Diffuse Optical Imaging (DOI) relies on the fact that near infrared light (600-1000 nm) is strongly scattered in biological tissue, and weakly absorbed by tissue chromophores such as blood, fat, water, and melanin. In frequency domain DOI, intensity modulated light is introduced into the tissue and the observed absorption and phase changes enable absolute concentrations of these chromophores to be calculated. These concentrations provide valuable insight into tissue metabolic activity that have proven useful for a variety of clinical outcomes from exercise physiology to predicting tumor response to treatment.

Diffuse Optical Tomography (DOT) is an extension of DOI that allows …

Conference Program, Peter So, Kate Bechtel, Ivo Vellekoop, Michael Choma

Advances in Optics for Biotechnology, Medicine and Surgery XV

No abstract provided.