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Full-Text Articles in Engineering
Delineating The Relationship Between Cardiovascular Physiology And Subject Characteristics Using Computational Modeling And Systemic Review, Aseem Pradhan
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Lumped Parameter Networks (LPN) are computational models that can capture the systemic responses of the cardiovascular system. An LPN describes the systemic behavior by providing outputs such as the blood pressure, flowrate, and heart chamber volume at the points defined in the network. To use the LPN for medical applications, it needs to provide output values that represent the physiology of realistic subjects. The cardiovascular system exhibits short-term and long-term adaptations to factors such as aging, weight gain, exercise, etc. Therefore, subject characteristics such as age, height, weight, etc. affect the output values of the LPN. Current literature reports the …
Risks And Benefits Of Using A Commercially Available Ventricular Assist Device For Failing Fontan Cavopulmonary Support: A Modeling Investigation, Masoud Farahmand, Minoo N. Kavarana, Ethan Kung
Risks And Benefits Of Using A Commercially Available Ventricular Assist Device For Failing Fontan Cavopulmonary Support: A Modeling Investigation, Masoud Farahmand, Minoo N. Kavarana, Ethan Kung
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Fontan patients often develop circulatory failure and are in desperate need of a therapeutic solution. A blood pump surgically placed in the cavopulmonary pathway can substitute the function of the absent sub-pulmonary ventricle by generating a mild pressure boost. However, there is currently no commercially available device designed for the cavopulmonary application; and the risks and benefits of implanting a ventricular assist device (VAD), originally designed for the left ventricular application, on the right circulation of failing Fontan patients is not yet clear. Moreover, further research is needed to compare the hemodynamics between the two clinically-considered surgical configurations for cavopulmonary …