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A Quantitative, Technology Independent, Fidelity Metric For Evaluating Bioprinted Patterned Co-Cultures, Matthew Pepper
A Quantitative, Technology Independent, Fidelity Metric For Evaluating Bioprinted Patterned Co-Cultures, Matthew Pepper
All Theses
The study of cell-cell interactions is crucial in the understanding of cell behaviors such as tumor genesis, proliferation, migration, metastasis, and apoptosis. To break down the complex web of signals in vivo, researchers must replicate some parts of this environment with in vitro tissue test systems, composed of multiple cell types arranged close enough to communicate with their neighbors, i.e. high-resolution co-culture patterns. The field of bioprinting is specifically focused on creating co-culture patterns for the purposes of cell studies, but the sample resolutions of most bioprinting systems are still too coarse to permit cell communication. No way currently exists …
Novel Nanofiber Structures And Advanced Tissue Engineering Applications, Vince Beachley
Novel Nanofiber Structures And Advanced Tissue Engineering Applications, Vince Beachley
All Dissertations
Extracellular matrix (ECM) nanofibers such as collagen and elastin make up an important component of natural tissues. These structural components serve to impart mechanical strength and provide locations for cell attachment and biomolecule storage. Cells respond to their structural environment in a wide variety of ways beyond physical support, and it has been demonstrated that this environment directly modulates cell behaviors such as, morphology, differentiation, ECM production, attachment, and migration. ECM nanofibers also play an important role as a template for tissue formation during development, remodeling, and regeneration. Nanofiber based tissue engineering strategies aim to mimic the geometry of the …