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Preparation And Characterization Of Particles From Chitosan With Different Molecular Weights And Their Trimethyl Chitosan Derivatives For Nasal Immunization, W Boonyo, H E. Junginger, N Waranuch, A Polnok, T Pitaksuteepong
Preparation And Characterization Of Particles From Chitosan With Different Molecular Weights And Their Trimethyl Chitosan Derivatives For Nasal Immunization, W Boonyo, H E. Junginger, N Waranuch, A Polnok, T Pitaksuteepong
Journal of Metals, Materials and Minerals
According to previous studies, molecular weights (MW) of chitosan presented an influence on the level of immune response to model antigen when administering with chitosan through nasal route. Moreover, trimethyl chitosan (TMC) with a degree of quaternization (DQ) of 40%, chitosan derivatives, was also shown to be the most potent nasal OVA delivery platforms compared to TMC with DQ of 20% and 60% in mice model. The aims of this study were to prepare particles from chitosan with difference MW and their TMC derivatives (DQ = 40%) and to characterize size, zeta potential, loading efficiency and release profile in order …