Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Engineering
Factors Affecting Preparations Of Chitosan Microcapsules For Colonic Drug Delivery, K Huanbutta, M Luangtana-Anan, P Sriamornsak, S Limmatvapirat, S Puttipipatkhachorn, J Nunthanid
Factors Affecting Preparations Of Chitosan Microcapsules For Colonic Drug Delivery, K Huanbutta, M Luangtana-Anan, P Sriamornsak, S Limmatvapirat, S Puttipipatkhachorn, J Nunthanid
Journal of Metals, Materials and Minerals
This work aimed at studying factors affecting preparations of chitosan microcapsules for colonic drug delivery. Chitosan microcores (CS, 45kDa, 87% degree of deacetylation) containing diclofenac sodium (DS) coated with Eudragit®S100 (ED) were prepared by a desolvation technique. Sodium sulfate was used as a desolvating agent and the drying process was freeze-drying. Factors affecting morphology, particle size and zeta potential of microcapsules were evaluated, i.e. weight ratio of DS:CS:ED, surfactant (polysorbate 80), anti-adherent (silicon dioxide), and the use of sonication or homogenization in preparation processes. The weight ratio of DS:CS:ED at 1:2:6 provided the smallest microcapsules of about 82.37±1.61 micrometer in …