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Full-Text Articles in Engineering
Modeling The Effects Of Parameter Changes On Heating And Pressure At The Weld Interface And Joint Strength In Friction Bit Joining, Adam Hartly Wagner
Modeling The Effects Of Parameter Changes On Heating And Pressure At The Weld Interface And Joint Strength In Friction Bit Joining, Adam Hartly Wagner
Theses and Dissertations
Joining of dissimilar metals is a process that is of interest in many fields, especially the automotive industry where lightweighting of the body structure is important. However, creating strong joints between dissimilar metals can be challenging. Friction bit joining (FBJ) is a solid-state method that uses a consumable bit to create a strong joint between dissimilar metals such as aluminum and steel. The purpose of this research is to gain understanding of how adjusting FBJ parameters affects the heating and pressure at the weld interface using a modeling approach, in order to better understand the bonding process. The questions guiding …
Molecular Dynamic Simulation Of Protein Devices And The Parameterization Of Azides And Alkynes For Use In Unnatural Amino Acid Models, Addison Kyle Smith
Molecular Dynamic Simulation Of Protein Devices And The Parameterization Of Azides And Alkynes For Use In Unnatural Amino Acid Models, Addison Kyle Smith
Theses and Dissertations
Proteins that have been modified by attaching them to a surface or to a polyethylene glycol (PEG) molecule can see many uses in therapeutics and diagnostics -- these unique proteins are called protein devices. Current techniques can perform these functionalizations at a specific residue on the protein, but what remains is identifying what happens to protein structure when mutated, and where to perform the attachment. Both of these issues can be examined using molecular dynamic (MD) simulations. Currently, simulations of the unnatural amino acid (uAA) mutations necessary for protein device functionalization cannot be executed, and full-protein screens of all possible …
Molecular Dynamic Simulation Of Protein Devices And The Parameterization Of Azides And Alkynes For Use In Unnatural Amino Acid Models, Addison Kyle Smith
Molecular Dynamic Simulation Of Protein Devices And The Parameterization Of Azides And Alkynes For Use In Unnatural Amino Acid Models, Addison Kyle Smith
Theses and Dissertations
Proteins that have been modified by attaching them to a surface or to a polyethylene glycol (PEG) molecule can see many uses in therapeutics and diagnostics -- these unique proteins are called protein devices. Current techniques can perform these functionalizations at a specific residue on the protein, but what remains is identifying what happens to protein structure when mutated, and where to perform the attachment. Both of these issues can be examined using molecular dynamic (MD) simulations. Currently, simulations of the unnatural amino acid (uAA) mutations necessary for protein device functionalization cannot be executed, and full-protein screens of all possible …