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Mathematical Model And Experimental Exploration Of The Nanoinjector Lance Array, Nathan C. Toone
Mathematical Model And Experimental Exploration Of The Nanoinjector Lance Array, Nathan C. Toone
Theses and Dissertations
The Nanoinjector Lance Array has been developed to inject foreign material into thousands of cells at once using electrophoresis to attract and repel particles to and from the electrically-charged lances. A mathematical computer model simulating the motion of attracted or repelled proteins informs the design of the nanoinjection lance array system. The model is validated by accurately predicting protein velocity in electrophoresis experiments. A complete analysis of parameters is conducted via simulations and specific research questions regarding the counter electrode of the nanoinjector lance array system are explored using the model. A novel technique for fabricating lance arrays from collapsed …
Multi-Processor Computation Of Thrombus Growth And Embolization In A Model Of Blood-Biomaterial Interaction Based On Fluid Dynamics, Brandon Thomas Andersen
Multi-Processor Computation Of Thrombus Growth And Embolization In A Model Of Blood-Biomaterial Interaction Based On Fluid Dynamics, Brandon Thomas Andersen
Theses and Dissertations
This work describes the development and testing of a real-time three-dimensional computational fluid dynamics simulation of thrombosis and embolization to be used in the design of blood-contacting devices. Features of the model include the adhesion and aggregation of blood platelets on device material surfaces, shear and chemical activation of blood platelets, and embolization of platelet aggregates due to shear forces. As thrombus develops, blood is diverted from its regular flow field. If shear forces on a thrombus are sufficient to overcome the strength of adhesion, the thrombus is dislodged from the wall. Development of the model included preparing thrombosis and …