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Full-Text Articles in Engineering
Novel Breath Collection Techniques For Detection Of Covid-19., James Morris
Novel Breath Collection Techniques For Detection Of Covid-19., James Morris
Electronic Theses and Dissertations
Volatile Organic Compounds (VOC) generated endogenously in the human body can be used to detect diseases that induce oxidative stress and inflammation. Breath analysis has been used for the detection of diseases such as COPD, Depression, Lung Cancer and most recently COVID-19. Methods such as Exhaled Breath Condensate (EBC), Sorbent Tubes, Solid Phase Microextraction (SPME), and silicon microreactors have shown considerable capability in extracting and concentrating trace VOC’s present in human breath. Silicon microreactors functionalized with capture agents to derivatize carbonyl compounds are effective but the overall maximum flow rate of breath sample possible during analysis is low, making direct …
Interrogating Autism From A Multidimensional Perspective: An Integrative Framework., Mohamed T. Ali
Interrogating Autism From A Multidimensional Perspective: An Integrative Framework., Mohamed T. Ali
Electronic Theses and Dissertations
Autism Spectrum Disorder (ASD) is a condition characterized by social and behavioral impairments, affecting approximately 1 in every 44 children in the United States. Common symptoms include difficulties in communication, interpersonal interactions, and behavior. While symptoms can manifest as early as infancy, obtaining an accurate diagnosis may require multiple visits to a pediatric specialist due to the subjective nature of the assessment, which may yield varying scores from different specialists. Despite growing evidence of the role of differences in brain development and/or environmental and/or genetic factors in autism development, the exact pathology of this disorder has yet to be fully …
Metabolomic Differentiation Of Tumor Core And Edge In Glioma., Mary E. Baxter
Metabolomic Differentiation Of Tumor Core And Edge In Glioma., Mary E. Baxter
Electronic Theses and Dissertations
Glioma is one of the most aggressive forms of brain cancer. It has been shown that the microenvironments differ significantly between the core and edge regions of glioma tumors. This study obtained metabolomic profiles of glioma core and edge regions using paired glioma core and edge tissue samples from 27 human patients. Data was acquired by performing liquid-liquid metabolite extraction and 2DLC-MS/MS on the tissue samples. In addition, a boosted generalized linear machine learning model was employed to predict the metabolomic profiles associated with O-6-methylguanine-DNA methyltransferase (MGMT) promoter methylation.
A panel of 66 metabolites was found to be statistically significant …