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Full-Text Articles in Engineering
Quantification Of In Vivo Oxidative Damage In Caenorhabditis Elegans During Aging By Endogenous F3-Isoprostane Measurement, Christiaan F. Labuschagne, Edwin C.A. Stigter, Margriet M.W.B. Hendriks, Ruud Berger, Joshua Rokach, Hendrik C. Korswagen, Arjan B. Brenkman
Quantification Of In Vivo Oxidative Damage In Caenorhabditis Elegans During Aging By Endogenous F3-Isoprostane Measurement, Christiaan F. Labuschagne, Edwin C.A. Stigter, Margriet M.W.B. Hendriks, Ruud Berger, Joshua Rokach, Hendrik C. Korswagen, Arjan B. Brenkman
Chemistry and Chemical Engineering Faculty Publications
Oxidative damage is thought to be a major cause in development of pathologies and aging. However, quantification of oxidative damage is methodologically difficult. Here, we present a robust liquid chromatography-tandem mass spectrometry (LC-MS/MS) approach for accurate, sensitive, and linear in vivo quantification of endogenous oxidative damage in the nematode Caenorhabditis elegans, based on F3-isoprostanes. F3-isoprostanes are prostaglandin-like markers of oxidative damage derived from lipid peroxidation by Reactive Oxygen Species (ROS). Oxidative damage was quantified in whole animals and in multiple cellular compartments, including mitochondria and peroxisomes. Mutants of the mitochondrial electron transport proteins mev-1 and clk-1 showed increased oxidative damage …
Aging Effect Evolution During Ferroelectric-Ferroelectric Phase Transition: A Mechanism Study, Zuyong Feng, Zhenxiang Cheng, Dongqi Shi, S X. Dou
Aging Effect Evolution During Ferroelectric-Ferroelectric Phase Transition: A Mechanism Study, Zuyong Feng, Zhenxiang Cheng, Dongqi Shi, S X. Dou
Australian Institute for Innovative Materials - Papers
Aging can significantly modify the dielectric, piezoelectric, and ferroelectric performance of ferroelectrics. However, little attention has been paid to the aging effect during ferroelectric-ferroelectric phase transitions that is essentially correlated with real applications. In this letter, the authors report the aging effect evolution between two ferroelectric phases in an acceptor-doped piezoceramics. The results show that aging-induced double hysteresis loops were exhibited in different ferroelectric phases, but disappeared during ferroelectric-ferroelectric phase transitions, suggesting the mechanism that the intrinsic restoring force for the reversible switching of domains caused by the alignment of defect dipoles was weakened due to ferroelectric dipole reorientation.