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Articles 1 - 15 of 15
Full-Text Articles in Engineering
Effect Of A Static Magnetic Field On Nanodosimetric Quantities In A Dna Volume, Peter Lazarakis, Marion U. Bug, Elisabetta Gargioni, Susanna Guatelli, Sabastien Incerti, Hans Rabus, Anatoly B. Rosenfeld
Effect Of A Static Magnetic Field On Nanodosimetric Quantities In A Dna Volume, Peter Lazarakis, Marion U. Bug, Elisabetta Gargioni, Susanna Guatelli, Sabastien Incerti, Hans Rabus, Anatoly B. Rosenfeld
Susanna Guatelli
Abstract Purpose: With the advent of magnetic resonance imaging (MRI)-guided radiation therapy it is becoming increasingly important to consider the potential influence of a magnetic field on ionising radiation. This paper aims to study the effect of a magnetic field on the track structure of radiation to determine if the biological effectiveness may be altered. Methods: Using the Geant4-DNA (GEometry ANd Tracking 4) Monte Carlo simulation toolkit, nanodosimetric track structure parameters were calculated for electrons, protons and alpha particles moving in transverse magnetic fields up to 10 Tesla. Applying the model proposed by Garty et al., the track structure parameters …
Introduction To The Geant4 Simulation Toolkit, Susanna Guatelli, D Cutajar, Bradley Oborn, Anatoly B. Rosenfeld
Introduction To The Geant4 Simulation Toolkit, Susanna Guatelli, D Cutajar, Bradley Oborn, Anatoly B. Rosenfeld
Susanna Guatelli
Geant4 is a Monte Carlo simulation Toolkit, describing the interactions of particles with matter. Geant4 is widely used in radiation physics research, from High Energy Physics, to medical physics and space science, thanks to its sophisticated physics component, coupled with advanced functionality in geometry description. Geant4 is widely used at the Centre for Medical Radiation Physics (CMRP), at the University of Wollongong, to characterise and optimise novel detector concepts, radiotherapy treatments, and imaging solutions. This lecture consists of an introduction to Monte Carlo method, and to Geant4. Particular attention will be devoted to the Geant4 physics component, and to the …
The Geant4-Dna Project, S Incerti, G Baldacchino, M Bernal, R Capra, C Champion, Z Francis, S Guatelli, P Gueye, A Mantero, B Mascialino, P Moretto, P Nieminen, Anatoly B. Rosenfeld, C Villagrasa, C Zacharatou
The Geant4-Dna Project, S Incerti, G Baldacchino, M Bernal, R Capra, C Champion, Z Francis, S Guatelli, P Gueye, A Mantero, B Mascialino, P Moretto, P Nieminen, Anatoly B. Rosenfeld, C Villagrasa, C Zacharatou
Susanna Guatelli
The Geant4-DNA project proposes to develop an open-source simulation software based and fully included in the general-purpose Geant4 Monte Carlo simulation toolkit. The main objective of this software is to simulate biological damages induced by ionising radiation at the cellular and sub-cellular scale. This project was originally initiated by the European Space Agency for the prediction of deleterious effects of radiation that may affect astronauts during future long duration space exploration missions. In this paper, the Geant4-DNA collaboration presents an overview of the whole ongoing project, including its most recent developments already available in the last Geant4 public release (9.3 …
Implementation Of A New Monte Carlo Simulation Tool For The Development Of A Proton Therapy Beam Line And Verification Of The Related Dose Distributions, G A. P Cirrone, G Cuttone, S Guatelli, S Lo Nigro, B Mascialino, M G. Pia, L Raffaele, G Russo, M G. Sabini
Implementation Of A New Monte Carlo Simulation Tool For The Development Of A Proton Therapy Beam Line And Verification Of The Related Dose Distributions, G A. P Cirrone, G Cuttone, S Guatelli, S Lo Nigro, B Mascialino, M G. Pia, L Raffaele, G Russo, M G. Sabini
Susanna Guatelli
Using the Monte Carlo simulation tool GEANT4 we simulated the hadron-therapy beam line of the CATANA center. CATANA is the unique italian hadron-therapy facility in which 62 AMeV proton beams are used for the radiotherapeutic treatment of choroidal and iris melanomas. All the elements, such as diffusers, range shifters, collimators and detectors, typical of a proton-therapy line were modelled. The CATANA beam line provides an ideal environment for the experimental testing and validation of the software developed. The software architecture was developed, and now the validation of the software is in its final stage. Simulated ranges, energy distribution, depth and …
Alpha Particle And Proton Relative Thermoluminescence Efficiencies In Lif:Mg,Cu,P:Is Track Structure Theory Up To The Task?, Y S. Horowitz, D Siboni, L Oster, J Livingstone, S Guatelli, Anatoly B. Rosenfeld, D Emfietzoglou, P Bilski, B Obryk
Alpha Particle And Proton Relative Thermoluminescence Efficiencies In Lif:Mg,Cu,P:Is Track Structure Theory Up To The Task?, Y S. Horowitz, D Siboni, L Oster, J Livingstone, S Guatelli, Anatoly B. Rosenfeld, D Emfietzoglou, P Bilski, B Obryk
Susanna Guatelli
"Low-energy alpha particle and proton heavy charged particle (HCP) relative thermoluminescence (TL) efficiencies are calculated for the major dosimetric glow peak in LiF:Mg,Cu,P (MCP-N) in the framework of track structure theory (TST). The calculations employ previously published TRIPOS-E Monte Carlo track segment values of the radial dose in condensed phase LiF calculated at the Instituto National de Investigaciones Nucleares (Mexico) and experimentally measured normalised Co-60 gamma-induced TL doseresponse functions, f(D), carried out at the Institute of Nuclear Physics (Poland). The motivation for the calculations is to test the validity of TST in a TL system in which f(D) is not …
Radiation Exposure And Mission Strategies For Interplanetary Manned Missions, C Cougnet, N Crosby, C Foullon, D Heynderickx, S Eckersley, V Guarnieri, C Lobascio, S Masiello, P Parodi, M A. Perino, R Rampini, Susanna Guatelli, Maria G. Pia, A Holmes-Siedle, P Nieminen, G Parisi, V Tamburini, P Spillantini, E Tracino
Radiation Exposure And Mission Strategies For Interplanetary Manned Missions, C Cougnet, N Crosby, C Foullon, D Heynderickx, S Eckersley, V Guarnieri, C Lobascio, S Masiello, P Parodi, M A. Perino, R Rampini, Susanna Guatelli, Maria G. Pia, A Holmes-Siedle, P Nieminen, G Parisi, V Tamburini, P Spillantini, E Tracino
Susanna Guatelli
Cosmic radiation is an important problem for human interplanetary missions. The ‘‘Radiation Exposure and Mission Strategies for Interplanetary Manned Missions–REMSIM’’ study is summarised here. They are related to current strategies and countermeasures to ensure the protection of astronauts from radiation during interplanetary missions, with specific reference to: radiation environment and its variability; radiation effects on the crew; transfer trajectories and associated fluences; vehicle and surface habitat concepts; passive and active shielding concepts; space weather monitoring and warning systems.
The Teaching/Research Nexus And Internationalisation: An Action Research Project In Radiation Physics, Susanna Guatelli, Catherine Layton, Dean Cutajar, Anatoly B. Rosenfeld
The Teaching/Research Nexus And Internationalisation: An Action Research Project In Radiation Physics, Susanna Guatelli, Catherine Layton, Dean Cutajar, Anatoly B. Rosenfeld
Susanna Guatelli
This paper attempts to unpack the teaching and learning experiences of academics and students when a new way of teaching radiation physics was introduced. In an attempt to articulate the University of Wollongong’s commitment to the enhancement of the teaching/research nexus and to the development of learning communities, staff of the School of Physics in the Faculty of Engineering at University of Wollongong (UOW) implemented an action research project teaching scientific computing methodologies used in radiation physics to a combined laboratory class of postgraduates and undergraduates. The design of the practical laboratory classes took account of the expected heterogeneous computing …
Tissue Equivalence Correction In Silicon Microdosimetry For Protons Characteristic Of The Leo Space Environment, Susanna Guatelli, Mark I. Reinhard, B Mascialino, Dale A. Prokopovich, A S. Dzurak, M Zaider, Anatoly B. Rosenfeld
Tissue Equivalence Correction In Silicon Microdosimetry For Protons Characteristic Of The Leo Space Environment, Susanna Guatelli, Mark I. Reinhard, B Mascialino, Dale A. Prokopovich, A S. Dzurak, M Zaider, Anatoly B. Rosenfeld
Susanna Guatelli
The tissue equivalence of solid state silicon detectors in proton radiation fields was determined to improve the radiation protection applications of silicon detectors in aviation and space missions. The study was performed by means of Geant4 simulations. Results are presented showing that a simple geometrical scaling factor (~0.56) of linear dimensions is adequate to convert experimentally obtained microdosimetric energy deposition spectra in silicon to equivalent microdosimetric energy deposition spectra in water.
Transferring Advanced Physics Research Tools To Education: How To Teach Simulation Tools Used In Radiation Physics Research To University Students, Susanna Guatelli, Catherine Anne Layton, Dean L. Cutajar, Anatoly B. Rosenfeld
Transferring Advanced Physics Research Tools To Education: How To Teach Simulation Tools Used In Radiation Physics Research To University Students, Susanna Guatelli, Catherine Anne Layton, Dean L. Cutajar, Anatoly B. Rosenfeld
Susanna Guatelli
At the Centre of Medical Radiation Physics (CMRP), School of Engineering Physics, Faculty of Engineering, at the University of Wollongong (UOW), we are implementing a hands-on computing laboratory, commencing in autumn 2010, to teach scientific computing methods and modern, advanced research tools for radiation physics to postgraduate and undergraduate students. Engaging undergraduates and postgraduates together in work with a tool widely used in research laboratories is a unique development, and represents the articulation of the University’s commitment to the enhancement of the teaching/research nexus, and to the development of learning communities. The object of the laboratory is to teach students …
Comparison Of Nanodosimetric Parameters Of Track Structure Calculated By The Monte Carlo Codes Geant4-Dna And Ptra, P Lazarakis, M U. Bug, E Gargioni, S Guatelli, H Rabus, Anatoly B. Rosenfeld
Comparison Of Nanodosimetric Parameters Of Track Structure Calculated By The Monte Carlo Codes Geant4-Dna And Ptra, P Lazarakis, M U. Bug, E Gargioni, S Guatelli, H Rabus, Anatoly B. Rosenfeld
Susanna Guatelli
The concept of nanodosimetry is based on the assumption that initial damage to cells is related to the number of ionizations (the ionization cluster size) directly produced by single particles within, or in the close vicinity of, short segments of DNA. The ionization cluster-size distribution and other nanodosimetric quantities, however, are not directly measurable in biological targets and our current knowledge is mostly based on numerical simulations of particle tracks in water, calculating track structure parameters for nanometric target volumes. The assessment of nanodosimetric quantities derived from particle-track calculations using different Monte Carlo codes plays, therefore, an important role for …
Validation Of Geant4 Atomic Relaxation Against The Nist Physical Reference Data, S. Guatelli, A. Mantero, B. Mascialino, Maria G. Pia, V. Zampichelli
Validation Of Geant4 Atomic Relaxation Against The Nist Physical Reference Data, S. Guatelli, A. Mantero, B. Mascialino, Maria G. Pia, V. Zampichelli
Susanna Guatelli
The accuracy of the Geant4 component for the simulation of atomic relaxation has been evaluated against the experimental measurements of the NIST Standard Reference Data. The validation study concerns X-ray andAuger transition energies. The comparison of the simulated and experimental data with rigorous statistical methods demonstrates the excellent accuracy of the simulation of atomic de-excitation in Geant4.
Background Dose For Systemic Targeted Alpha Therapy, Chen-Yu Huang, Susanna Guatelli, Bradley Oborn, Barry J. Allen
Background Dose For Systemic Targeted Alpha Therapy, Chen-Yu Huang, Susanna Guatelli, Bradley Oborn, Barry J. Allen
Susanna Guatelli
The phase 1 clinical trial of systemic Targeted Alpha Therapy for metastatic melanoma has shown that solid tumours can be regressed by alpha radiation. However, patient blood vessels and lymphocytes inevitably received a background radiation from non-targeted alpha decays in the blood circulation. To determine the toxicity of alpha particle to normal tissue capillaries and peripheral blood lymphocytes, capillary and lymphocyte models were established with Geant4 Monte Carlo microdosimetry technique. The specific energy deposited in a capillary endothelial cell nucleus or lymphocyte nucleus per radioactive decay and the cell survival rates were calculated for the source constrained in the vessel. …
Packaging Effects On Radfet Sensors For High Energy Physics Experiments, Julien Mekki, Laurent Dusseau, Maurice Glaser, Susanna Guatelli, Michael Moll, Maria Grazia Pia, Federico Ravotti
Packaging Effects On Radfet Sensors For High Energy Physics Experiments, Julien Mekki, Laurent Dusseau, Maurice Glaser, Susanna Guatelli, Michael Moll, Maria Grazia Pia, Federico Ravotti
Susanna Guatelli
RadFETs in customized chip carrier packages are installed in the LHC Experiments as radiation monitors. The package influence on the dose measurement in the complex LHC radiation environment is evaluated using Geant4 simulations and experimental data.
Neutron Dosimeter Development Based On Medipix2, Mohd Amir R. Othman, Marco Petasecca, Susanna Guatelli, J. Uher, Damion Marinaro, Dale A. Prokopovich, Mark I. Reinhard, Michael L. F. Lerch, J. Jakubek, S. Pospisil, Anatoly B. Rosenfeld
Neutron Dosimeter Development Based On Medipix2, Mohd Amir R. Othman, Marco Petasecca, Susanna Guatelli, J. Uher, Damion Marinaro, Dale A. Prokopovich, Mark I. Reinhard, Michael L. F. Lerch, J. Jakubek, S. Pospisil, Anatoly B. Rosenfeld
Susanna Guatelli
A novel neutron dosimetry system for avionics and space applications is described. The new dosimetric system is based on Medipix2, a high density silicon based pixilated detector with integrated readout and digital interface circuitry. Real time dose equivalent response to fast neutron fields with flattened energy response is achieved through the coupling of a structured variable thickness polyethylene (PE) over layer with the high density pixilated detector. Experimental results obtained to 14 MeV D-T and Am-Be neutron fields are described along with a comparison to results obtained with GEANT4 simulations.
Geant4 Atomic Relaxation, Susanna Guatelli, Alfonso Mantero, Barbara Mascialino, Petteri Nieminen, Maria Grazia Pia
Geant4 Atomic Relaxation, Susanna Guatelli, Alfonso Mantero, Barbara Mascialino, Petteri Nieminen, Maria Grazia Pia
Susanna Guatelli
The Low Energy Electromagnetic package of the Geant4 toolkit incorporates a component for the simulation of atomic relaxation of elements with atomic number between 6 and 100. This process is triggered by the creation of a vacancy in the atomic shell occupancy as a result of an incident particle interaction with an atom of the target material. X-ray fluorescence and Auger electron emission result from the relaxation cascade. The availability of a model handling the atomic relaxation in Geant4 extends the applicability of the simulation toolkit to experimental use cases concerning the investigation of material properties through their characteristic X-ray …