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A Dual Approach For Positive T–S Fuzzy Controller Design And Its Application To Cancer Treatment Under Immunotherapy And Chemotherapy, Elham Ahmadi, Jafar Zarei, Roozbeh Razavi-Far, Mehrdad Saif

Electrical and Computer Engineering Publications

This study proposes an effective positive control design strategy for cancer treatment by resorting to the combination of immunotherapy and chemotherapy. The treatment objective is to transfer the initial number of tumor cells and immune–competent cells from the malignant region into the region of benign growth where the immune system can inhibit tumor growth. In order to achieve this goal, a new modeling strategy is used that is based on Takagi–Sugeno. A Takagi-Sugeno fuzzy model is derived based on the Stepanova nonlinear model that enables a systematic design of the controller. Then, a positive Parallel Distributed Compensation controller is proposed …