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Full-Text Articles in Engineering
Elucidating Mammalian Cellular Responses To The Uptake Of Nanoparticles (Nps), Pathogens, And Lipoproteins: Similarities And Differences, Monireh Asoudeh
Elucidating Mammalian Cellular Responses To The Uptake Of Nanoparticles (Nps), Pathogens, And Lipoproteins: Similarities And Differences, Monireh Asoudeh
Doctoral Dissertations
Soft poly-ethylene-glycol (PEG)-based soft nanoparticles (NPs) including cylindrical (CNPs) micelles, spherical (SNPs) micelles, and lipid bilayer vesicles (LNPs) are thought to be treated as foreign objects by mammalian phagocytes. If this hypothesis is true, NPs should trigger a proinflammatory, autophagic phenotype that is similar to the one seen when macrophages phagocytose pathogens or when macrophage surface expressed proteins bind pathogen surface factors such as lipopolysaccharide (LPS). Here, we show that macrophage responses to the above NPs are almost completely unique from those triggered by group A streptococcus (GAS) pathogens (JRS4 cells) and LPS. Instead, macrophages treat these soft NPs more …
The Role Of Extracellular Polymeric Substances In The Accumulation And Transport Of Polystyrene Nanoparticles In Biofilms, Joann Marie Rodríguez Suarez
The Role Of Extracellular Polymeric Substances In The Accumulation And Transport Of Polystyrene Nanoparticles In Biofilms, Joann Marie Rodríguez Suarez
Doctoral Dissertations
With the increasing number of nanotechnology applications, it is reasonable to expect nanoparticles to be ubiquitous in biofilms found in natural and engineered aquatic systems. We studied the impact of the degree of cross-linking on the deposition and diffusion of polystyrene nanoparticles (NPs) in alginate model biofilm matrices in the presence and absence of calcium cross-linkers using image correlation methods and single particle tracking. We found that cross-linking increases the viscoelasticity and hydration of the polymeric matrix and leads to structural changes that can restrict and alter the diffusive behavior of NPs, but the magnitude of the effects on diffusion …