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Laterally Loaded Rigid Piles With Rotational Constraints, Wei Dong Guo
Laterally Loaded Rigid Piles With Rotational Constraints, Wei Dong Guo
Faculty of Engineering and Information Sciences - Papers: Part A
Elastic-plastic, closed-form solutions were developed recently by the author, to capture the nonlinear response of laterally loaded rigid piles. Presented in compact form, the solutions are convenient to use, and sufficiently accurate despite using only two input parameters of the net limiting force per unit length pu along the pile, and a subgrade modulus k. Nevertheless, piles may be subjected to limited cap-restraints or loading below ground surface, which alter the response remarkably.This paper provides explicit expressions for estimating loading capacity of anchored piles and develops new solutions for lateral piles with cap-rotation by stipulating a constant pu or a …
Levetiracetam-Loaded Biodegradable Polymer Implants In The Tetanus Toxin Model Of Temporal Lobe Epilepsy In Rats, Amy J. Halliday, Toni E. Campbell, Timothy S. Nelson, Karen J. Mclean, Gordon G. Wallace, Mark J. Cook
Levetiracetam-Loaded Biodegradable Polymer Implants In The Tetanus Toxin Model Of Temporal Lobe Epilepsy In Rats, Amy J. Halliday, Toni E. Campbell, Timothy S. Nelson, Karen J. Mclean, Gordon G. Wallace, Mark J. Cook
Australian Institute for Innovative Materials - Papers
Approximately one-third of people with epilepsy receive insufficient benefit from currently available anticonvulsant medication, and some evidence suggests that this may be due to a lack of effective penetration into brain parenchyma. The current study investigated the ability of biodegradable polymer implants loaded with levetiracetam to ameliorate seizures following implantation above the motor cortex in the tetanus toxin model of temporal lobe epilepsy in rats. The implants led to significantly shorter seizures and a trend towards fewer seizures for up to 1 week. The results of this study indicate that drug-eluting polymer implants represent a promising evolving treatment option for …