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In Vitro And In Vivo Study Of Sustained Nitric Oxide Release Coating Using Diazeniumdiolate-Doped Poly(Vinyl Chloride) Matrix With Poly(Lactide-Co-Glycolide) Additive, Hitesh Handa, Elizabeth J. Brisbois, Terry E. Robinson, Lahdan Refahiyat, Kagya Amoako, Robert H. Bartlett, Mark E. Meyerhoff
In Vitro And In Vivo Study Of Sustained Nitric Oxide Release Coating Using Diazeniumdiolate-Doped Poly(Vinyl Chloride) Matrix With Poly(Lactide-Co-Glycolide) Additive, Hitesh Handa, Elizabeth J. Brisbois, Terry E. Robinson, Lahdan Refahiyat, Kagya Amoako, Robert H. Bartlett, Mark E. Meyerhoff
Mechanical and Industrial Engineering Faculty Publications
Nitric oxide (NO) is an endogenous vasodilator as well as natural inhibitor of platelet adhesion and activation that can be released from a NO donor species, such as diazeniumdiolated dibutylhexanediamine (DBHD/N2O2) within a polymer coating. In this study, various Food and Drug Administration approved poly(lactic-co-glycolic acid) (PLGA) species were evaluated as additives to promote a prolonged NO release from DBHD/N2O2 within a plasticized poly(vinyl chloride) (PVC) matrix. When using an ester-capped PLGA additive with a slow hydrolysis time, the resulting coatings continuously release between 7 and 18 × 10−10 mol cm−2 min−1 NO for 14 days at 37 °C in …