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University of Kentucky

Theses/Dissertations

2018

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Full-Text Articles in Engineering

Numerical Simulations Of Premixed Flames Of Multi Component Fuels/Air Mixtures And Their Applications, Essa Kh I J Salem Dec 2018

Numerical Simulations Of Premixed Flames Of Multi Component Fuels/Air Mixtures And Their Applications, Essa Kh I J Salem

Theses and Dissertations--Mechanical Engineering

Combustion has been used for a long time as a means of energy extraction. However, in the recent years there has been further increase in air pollution, through pollutants such as nitrogen oxides, acid rain etc. To solve this problem, there is a need to reduce carbon and nitrogen oxides through lean burning, fuel dilution and usage of bi-product fuel gases. A numerical analysis has been carried out to investigate the effectiveness of several reduced mechanisms, in terms of computational time and accuracy. The cases were tested for the combustion of hydrocarbons diluted with hydrogen, syngas, and bi-product fuel in …


Two Essays On Whole Farm Modeling And Crop Marketing In Western Kentucky, Benjamin A. Martin Jan 2018

Two Essays On Whole Farm Modeling And Crop Marketing In Western Kentucky, Benjamin A. Martin

Theses and Dissertations--Agricultural Economics

This thesis is composed of two essays that investigate whole farm planning and crop marketing in western Kentucky. In the first essay, contracting decisions between food corn producers and a mill are analyzed to observe factors affecting the bushel amount farmers contract. Unbalanced panel data containing seven years’ worth of pricing and contract information are used with a fixed-effects model to generate parameter estimates and quantify their effect on bushels contracted. It was found that contract attributes, market condition, and relationship-specific assets had a significant effect on producers’ food corn contracting decisions. The second essay utilizes mixed-integer programming to optimize …


Fractionation Of Lignin Derived Compounds From Thermochemically Processed Lignin Towards Antimicrobial Properties, Luke A. Dodge Jan 2018

Fractionation Of Lignin Derived Compounds From Thermochemically Processed Lignin Towards Antimicrobial Properties, Luke A. Dodge

Theses and Dissertations--Biosystems and Agricultural Engineering

The overuse of antibiotics in agriculture is an emerging concern, due to their potential detrimental impact to the environment. This study focuses on exploring antimicrobial properties of lignin derived compounds. Lignin is of interest as a feedstock to replacing some petroleum-based chemicals and products because it is the most abundant source of renewable aromatic compounds on the planet. Two lignin rich streams, residues from the enzymatic hydrolysis of dilute acid and alkaline pretreated corn stover, were decomposed via pyrolysis and hydrogenolysis, respectively. The resulting liquid oils were subjected to sequential extractions using a series of solvents with different polarities. Chemical …


Scale Models Of Acoustic Scattering Problems Including Barriers And Sound Absorption, Nan Zhang Jan 2018

Scale Models Of Acoustic Scattering Problems Including Barriers And Sound Absorption, Nan Zhang

Theses and Dissertations--Mechanical Engineering

Scale modeling has been commonly used for architectural acoustics but use in other noise control areas is nominal. Acoustic scale modeling theory is first reviewed and then feasibility for small-scale applications, such as is common in the electronics industry, is investigated. Three application cases are used to examine the viability. In the first example, a scale model is used to determine the insertion loss of a rectangular barrier. In the second example, the transmission loss through parallel tubes drilled through a cylinder is measured and results are compared to a 2.85 times scale model with good agreement. The third example …


Investigation Of The Effectiveness Of An Integrated Flooded-Bed Dust Scrubber On A Longwall Shearer Through Laboratory Testing And Cfd Simulation, Sampurna N. Arya Jan 2018

Investigation Of The Effectiveness Of An Integrated Flooded-Bed Dust Scrubber On A Longwall Shearer Through Laboratory Testing And Cfd Simulation, Sampurna N. Arya

Theses and Dissertations--Mining Engineering

Dust generation at an underground coal mine working face continues to be a health and safety issue. Prolonged exposure to high concentrations of airborne respirable dust can cause a debilitating and often fatal respiratory disease called Black Lung. In addition, the deposition of float dust in mine return airways poses a serious safety hazard if not sufficiently diluted with inert rock dust. A localized methane explosion can transition into a self-propagating dust explosion. Since dust is a byproduct of various mining activities, such as cutting and loading, crushing, and transportation, the dust-related issues cannot be totally eliminated. However, the adverse …


Contributions To Hybrid Power Systems Incorporating Renewables For Desalination Systems, Nasser Alawhali Jan 2018

Contributions To Hybrid Power Systems Incorporating Renewables For Desalination Systems, Nasser Alawhali

Theses and Dissertations--Electrical and Computer Engineering

Renewable energy is one of the most reliable resource that can be used to generate the electricity. It is expected to be the most highly used resource for electricity generation in many countries in the world in the next few decades. Renewable energy resources can be used in several purposes. It can be used for electricity generation, water desalination and mining. Using renewable resources to desalinate the water has several advantages such as reduce the emission, save money and improve the public health. The research described in the thesis focuses on the analysis of using the renewable resources such as …


Numerical And Experimental Techniques For Assessing The Acoustic Performance Of Duct Systems Above The Plane Wave Cutoff Frequency, Kangping Ruan Jan 2018

Numerical And Experimental Techniques For Assessing The Acoustic Performance Of Duct Systems Above The Plane Wave Cutoff Frequency, Kangping Ruan

Theses and Dissertations--Mechanical Engineering

This research deals with determining the acoustic attenuation of heating, ventilation, and air conditioning (HVAC) ductwork. A finite element approach was developed for calculating insertion loss and breakout transmission loss. Procedures for simulating the source and receiving rooms were developed and the effect of structureborne flanking was included. Simulation results have been compared with measurements from the literature and the agreement is very good. With a good model in place, the work was extended in three ways. 1) Since measurements on full-scale equipment are difficult, scale modeling rules were developed and validated. 2) Two different numerical approaches were developed for …


Magneto-Optical Properties Of Thin Permalloy Films: A Study Of The Magneto-Optical Generation Of Light Carrying Angular Momentum, Patrick D. Montgomery Jan 2018

Magneto-Optical Properties Of Thin Permalloy Films: A Study Of The Magneto-Optical Generation Of Light Carrying Angular Momentum, Patrick D. Montgomery

Theses and Dissertations--Electrical and Computer Engineering

Magneto-optical materials such as permalloy can be used to create artificial spin- ice (ASI) lattices with antiferromagnetic ordering. Magneto-optical materials used to create diffraction lattices are known to exhibit magnetic scattering at the half- order Bragg peak while in the ground state. The significant drawbacks of studying the magneto-optical generation of OAM using x-rays are cost, time, and access to proper equipment. In this work, it is shown that the possibility of studying OAM and magneto-optical materials in the spectrum of visible light at or around 2 eV is viable. Using spectroscopic ellipsometry it is possible to detect a change …


Fabrication And Characterization Of Organic-Inorganic Hybrid Perovskite Solar Cells, Hojjatollah Sarvari Jan 2018

Fabrication And Characterization Of Organic-Inorganic Hybrid Perovskite Solar Cells, Hojjatollah Sarvari

Theses and Dissertations--Electrical and Computer Engineering

Solar energy as the most abundant source of energy is clean, non-pollutant, and completely renewable, which provides energy security, independence, and reliability. Organic-inorganic hybrid perovskite solar cells (PSCs) revolutionized the photovoltaics field not only by showing high efficiency of above 22% in just a few years but also by providing cheap and facile fabrication methods.

In this dissertation, fabrication of PSCs in both ambient air conditions and environmentally controlled N2-filled glove-box are studied. Several characterization methods such as SEM, XRD, EDS, Profilometry, four-point probe measurement, EQE, and current-voltage measurements were employed to examine the quality of thin films …


Self-Image Multimedia Technologies For Feedforward Observational Learning, Nkiruka M. A. Uzuegbunam Jan 2018

Self-Image Multimedia Technologies For Feedforward Observational Learning, Nkiruka M. A. Uzuegbunam

Theses and Dissertations--Electrical and Computer Engineering

This dissertation investigates the development and use of self-images in augmented reality systems for learning and learning-based activities. This work focuses on self- modeling, a particular form of learning, actively employed in various settings for therapy or teaching. In particular, this work aims to develop novel multimedia systems to support the display and rendering of augmented self-images. It aims to use interactivity (via games) as a means of obtaining imagery for use in creating augmented self-images. Two multimedia systems are developed, discussed and analyzed. The proposed systems are validated in terms of their technical innovation and their clinical efficacy in …


Adrenergic Stimulation In Acute Hyperglycemia: Effects On Cellular And Tissue Level Murine Cardiac Electrophysiology, Sridevi Thyagarajan Jan 2018

Adrenergic Stimulation In Acute Hyperglycemia: Effects On Cellular And Tissue Level Murine Cardiac Electrophysiology, Sridevi Thyagarajan

Theses and Dissertations--Biomedical Engineering

Cardiovascular complications associated with elevated levels of glucose in the blood (Hyperglycemia, HG) is a growing health concern. HG is known to be associated with a variety of cardiovascular morbidities including higher incidence of electrical disturbances. Although effects of chronic HG have been widely investigated, electrophysiological effects of acute hyperglycemia are relatively less known. Further, hyperglycemic effects on adrenergic response is not widely investigated. We used excised ventricular tissues from mice to record trans-membrane potentials during a variety of pacing protocols to investigate cellular/tissue level electrophysiological effects of acute hyperglycemia and adrenergic stimulation (1µM Isoproterenol, a β-adrenergic agonist). A custom …


Effects Of Lumbar Spinal Fusion On Lumbopelvic Rhythm During Activities Of Daily Living, Cameron G. Slade Jan 2018

Effects Of Lumbar Spinal Fusion On Lumbopelvic Rhythm During Activities Of Daily Living, Cameron G. Slade

Theses and Dissertations--Biomedical Engineering

Abnormalities in lumbopelvic rhythm (LPR) play a role in occurrence/recurrence of low back pain (LBP). The LPR before spinal fusion surgery and its changes following the surgery are not understood. A repeated measure study was designed to investigate timing and magnitude aspects of LPR in a group of patients (n = 5) with LBP before and after a spinal fusion surgery. Participants completed a forward bending and backward return task at their preferred pace in the sagittal plane. The ranges of thoracic and pelvic rotations and lumbar flexion (as the magnitude aspects of LPR) as well as the mean absolute …


Defect Chemistry And Transport Properties Of Solid State Materials For Energy Storage Applications, Xiaowen Zhan Jan 2018

Defect Chemistry And Transport Properties Of Solid State Materials For Energy Storage Applications, Xiaowen Zhan

Theses and Dissertations--Chemical and Materials Engineering

Replacing organic liquid electrolytes with nonflammable solid electrolytes can improve safety, offer higher volumetric and gravimetric energy densities, and lower the cost of lithium-ion batteries. However, today’s all-solid-state batteries suffer from low Li-ion conductivity in the electrolyte, slow Li-ion transport across the electrolyte/electrode interface, and slow solid-state Li-ion diffusion within the electrode. Defect chemistry is critical to understanding ionic conductivity and predicting the charge transport through heterogeneous solid interfaces. The goal of this dissertation is to analyze and improve solid state materials for energy storage applications by understanding their defect structure and transport properties.

I have investigated defect chemistry of …


Synthesis And Characterization Of Magnesium - Titanium Composites By Severe Plastic Deformation, Baleegh Alobaid Jan 2018

Synthesis And Characterization Of Magnesium - Titanium Composites By Severe Plastic Deformation, Baleegh Alobaid

Theses and Dissertations--Chemical and Materials Engineering

Magnesium alloys are widely used in engineering applications, including aerospace and automobile industries, due to their desirable properties, such as lower density, high damping capacity, relatively high thermal conductivity, good machinability, and recyclability. Researchers have, therefore, been developing new magnesium materials. However, mechanical and corrosion properties are still limiting many commercial applications of magnesium alloys. In this Ph.D. thesis research, I developed Mg-Ti composite materials to offer some solutions to further improve the mechanical behavior of magnesium, such as titanium-magnesium (Ti-Mg) claddings, Mg-Ti multilayers, and Ti particle enforced Mg alloys. Low cost manufacturing processes, such as hot roll-bonding (RB) and …


The Physical Behavior And Characterization Of Nanoporous Silicon And Dispenser Cathode Surfaces, Tyler Lucius Corey Maxwell Jan 2018

The Physical Behavior And Characterization Of Nanoporous Silicon And Dispenser Cathode Surfaces, Tyler Lucius Corey Maxwell

Theses and Dissertations--Chemical and Materials Engineering

Nanostructured materials have received a surge of interest in recent years since it has become apparent that reducing the size of a material often leads to heightened mechanical behavior. From a fundamental standpoint, this stems from the confinement of dislocations. Applications in microelectromechanical devices, lithium ion batteries, gas sensing and catalysis are realized by combining the improvements in mechanical behavior from material size reduction with the heightened chemical activity offered by materials with a high surface-area-to-volume ratio. In this study, films of nanoporous Si-Mg were produced through magnetron sputtering, followed by dealloying using an environmentally benign process with distilled water. …


Evaluation And Prevention Of Spontaneous Combustion During Handling And Storage Of Coal, Amir E. Najarzadeh Jan 2018

Evaluation And Prevention Of Spontaneous Combustion During Handling And Storage Of Coal, Amir E. Najarzadeh

Theses and Dissertations--Mining Engineering

Spontaneous combustion of coal has historically been a major problem for the coal industry, predominantly during storage and transportation. Various methods have been used in the laboratory for evaluating the propensity of different coal sources to self-heat. However, the heterogeneity of coal and the complexity of the system has resulted in inconsistencies and sometimes conflicting results as indicated by the findings reported in several publications.

The primary objective of the current study was to build a laboratory scale apparatus that simulates the condition of a coal stockpile to evaluate the events leading to spontaneous combustion and develop potential remedies. As …


Effects Of Backpack Type On Kinematics Of The Lower Back During Walking And Jogging, Cazmon Suri Jan 2018

Effects Of Backpack Type On Kinematics Of The Lower Back During Walking And Jogging, Cazmon Suri

Theses and Dissertations--Biomedical Engineering

Heavy backpacks have been suggested to have a pathogenic role in experience of low back pain among children. We have conducted a repeated-measure study to investigate the backpack-induced changes in lumbo-pelvic coordination of forty gender-balanced college age students when they walked and jogged on a treadmill with two different types of backpacks: normal and ergonomically modified. The backpack-induced changes in lumbo-pelvic coordination were larger when carrying an ergonomically modified vs. a normal backpack as well as when jogging versus walking. The larger changes in lumbo-pelvic coordination when carrying an ergonomically modified backpack were likely due to kinematic restraints imposed by …


Assessing The Spatial Accuracy And Precision Of Lidar For Remote Sensing In Agriculture, Surya Saket Dasika Jan 2018

Assessing The Spatial Accuracy And Precision Of Lidar For Remote Sensing In Agriculture, Surya Saket Dasika

Theses and Dissertations--Biosystems and Agricultural Engineering

The objective of this whole study was to evaluate a LiDAR sensor for high-resolution remote sensing in agriculture. A linear motion system was developed to precisely control the dynamics of LiDAR sensor in effort to remove uncertainty in the LiDAR position/velocity while under motion. A user control interface was developed to operate the system under different velocity profiles and log LiDAR data synchronous to the motion of the system. The LiDAR was then validated using multiple test targets with five different velocity profiles to determine the effect of sensor velocity and height above a target on measurement error. The results …


Numerical Analysis Of Stress Distributions For Multiple Backfilled Stopes, Christopher Richard Newman Jan 2018

Numerical Analysis Of Stress Distributions For Multiple Backfilled Stopes, Christopher Richard Newman

Theses and Dissertations--Mining Engineering

Over the past three decades, technological innovations with respect to cemented paste backfill (CPB) as a means of ground support has allowed for increased production within the mining industry, management mine waste costs, as well as the improvement of the overall health and safety of underground mining operations. Despite the extensive use of this relatively new ground support material, many fundamental factors affecting the design of safe and economical CPB structures are still not well understood.Recently, a significant amount of academic and industry research has been conducted to better understanding the distribution of stress with respect to primary-secondary extraction sequencing …


Analysis Of Underground Coal Mine Structures Subjected To Dynamic Events, Brooklynn Yonts Jan 2018

Analysis Of Underground Coal Mine Structures Subjected To Dynamic Events, Brooklynn Yonts

Theses and Dissertations--Mining Engineering

Underground coal mine explosions pose a significant threat to infrastructure such as mine seals and refuge alternative chambers. After a mine seal failed in the Sago mine disaster, which took the life of 12 miners, design requirements were reexamined and improved. However, most research being completed on the analysis of mine structures during an explosive event focuses solely on peak pressure values, while ignoring the impact of pressure duration. This study investigates the impact pressure duration, waveform shape, and impulse have on structural displacement, while also exploring what pressures and duration can be expected during a mine explosion. Additionally, the …


Advanced Synchronous Machine Modeling, Yuqi Zhang Jan 2018

Advanced Synchronous Machine Modeling, Yuqi Zhang

Theses and Dissertations--Electrical and Computer Engineering

The synchronous machine is one of the critical components of electric power systems. Modeling of synchronous machines is essential for power systems analyses. Electric machines are often interfaced with power electronic components. This work presents an advanced synchronous machine modeling, which emphasis on the modeling and simulation of systems that contain a mixture of synchronous machines and power electronic components. Such systems can be found in electric drive systems, dc power systems, renewable energy, and conventional synchronous machine excitation. Numerous models and formulations have been used to study synchronous machines in different applications. Herein, a unified derivation of the various …


Interactive Clinical Event Pattern Mining And Visualization Using Insurance Claims Data, Zhenhui Piao Jan 2018

Interactive Clinical Event Pattern Mining And Visualization Using Insurance Claims Data, Zhenhui Piao

Theses and Dissertations--Computer Science

With exponential growth on a daily basis, there is potentially valuable information hidden in complex electronic medical records (EMR) systems. In this thesis, several efficient data mining algorithms were explored to discover hidden knowledge in insurance claims data. The first aim was to cluster three levels of information overload(IO) groups among chronic rheumatic disease (CRD) patient groups based on their clinical events extracted from insurance claims data. The second aim was to discover hidden patterns using three renowned pattern mining algorithms: Apriori, frequent pattern growth(FP-Growth), and sequential pattern discovery using equivalence classes(SPADE). The SPADE algorithm was found to be the …


Hydrologic Monitoring And 2-D Electrical Resistivity Imaging For Joint Geophysical And Geotechnical Characterization Of Shallow Colluvial Landslides, Matthew M. Crawford Jan 2018

Hydrologic Monitoring And 2-D Electrical Resistivity Imaging For Joint Geophysical And Geotechnical Characterization Of Shallow Colluvial Landslides, Matthew M. Crawford

Theses and Dissertations--Earth and Environmental Sciences

Landslide characterization and hazard assessments require multidisciplinary approaches that connect geologic processes with geotechnical parameters. Field monitoring of hydrologic variables such as water content and water potential, coupled with geoelectrical measurements that can establish relationships used for geotechnical and landslide hazard investigations is deficient.

This study brings together different techniques to develop a methodology that connects geoelectrical measurements and shear strength. A field-based framework was established that includes (1) analysis of long-term soil moisture fluctuations within different landslides (2) establishment of constitutive and new equations that test the use of electrical conductivity to predict soil-water relationships and shear strength (3) …


Assessing The Application Of The Unmanned Aerial Systems (Uas) In Earthwork Volume Measurement, Xi Wang Jan 2018

Assessing The Application Of The Unmanned Aerial Systems (Uas) In Earthwork Volume Measurement, Xi Wang

Theses and Dissertations--Civil Engineering

Earthwork operations are often one of the major cost items on infrastructure construction projects. Because earthwork is largely influenced by unstable construction conditions and organization plans, it becomes the emphasis and difficulties of the cost control in the construction process. Therefore, precise estimates of actual earthwork volumes are important for both owners and contractors alike to ensure appropriate payments are made. However, measuring work on site requires lots of time and labors because of various and irregular site conditions. Conventional measurement methods, such as planned quantities from the drawings or estimates from equipment activity, are rough estimates with significant opportunities …


3d Human Face Reconstruction And 2d Appearance Synthesis, Yajie Zhao Jan 2018

3d Human Face Reconstruction And 2d Appearance Synthesis, Yajie Zhao

Theses and Dissertations--Computer Science

3D human face reconstruction has been an extensive research for decades due to its wide applications, such as animation, recognition and 3D-driven appearance synthesis. Although commodity depth sensors are widely available in recent years, image based face reconstruction are significantly valuable as images are much easier to access and store.

In this dissertation, we first propose three image-based face reconstruction approaches according to different assumption of inputs.

In the first approach, face geometry is extracted from multiple key frames of a video sequence with different head poses. The camera should be calibrated under this assumption.

As the first approach is …


Multimodal Noncontact Diffuse Optical Reflectance Imaging Of Blood Flow And Fluorescence Contrasts, Daniel Irwin Jan 2018

Multimodal Noncontact Diffuse Optical Reflectance Imaging Of Blood Flow And Fluorescence Contrasts, Daniel Irwin

Theses and Dissertations--Biomedical Engineering

In this study we design a succession of three increasingly adept diffuse optical devices towards the simultaneous 3D imaging of blood flow and fluorescence contrasts in relatively deep tissues. These metrics together can provide future insights into the relationship between blood flow distributions and fluorescent or fluorescently tagged agents. A noncontact diffuse correlation tomography (ncDCT) device was firstly developed to recover flow by mechanically scanning a lens-based apparatus across the sample. The novel flow reconstruction technique and measuring boundary curvature were advanced in tandem. The establishment of CCD camera detection with a high sampling density and flow recovery by speckle …


Sleep And Thermoregulation: A Study Of The Effect Of Ambient Temperature Manipulation On Mouse Sleep Architecture, Asma'a A. Ajwad Jan 2018

Sleep And Thermoregulation: A Study Of The Effect Of Ambient Temperature Manipulation On Mouse Sleep Architecture, Asma'a A. Ajwad

Theses and Dissertations--Biomedical Engineering

Good quality sleep is essential for mental and physical health. Inadequate sleep impacts memory consolidation, learning and cognition, immune function, autonomic regulation, physical performance, and other vital functions. In many neurological disorders that are associated with sleep problems such as epilepsy and Alzheimer’s disease, changes in brain circuitry affect sleep-wake regulation mechanisms; this is reflected in anomalous sleep-wake architecture and usually accompanied by poor sleep depth. Thus, over many years, many approaches have been tried in humans and animal models with the goal of improving sleep quality. Unfortunately, each of those approaches comes with limitations or side effects. Thus, there …


Segmentation Strategies For Road Safety Analysis, Eric R. Green Jan 2018

Segmentation Strategies For Road Safety Analysis, Eric R. Green

Theses and Dissertations--Civil Engineering

This dissertation addresses the relationship between roadway segment length and roadway attributes and their relationship to the efficacy of Safety Performance Function (SPF) models. This research focuses on three aspects of segmentation: segment length, roadway attributes, and combinations of the two. First, it is shown that choice of average roadway segment length can result in markedly different priority lists. This leads to an investigation of the effect of segment length on the development of SPFs and identifies average lengths that produce the best-fitting SPF. Secondly, roadway attributes are filtered to test the effect that homogeneity has on SPF development. Lastly, …


Understanding Inhibition Of A Biodesulfurization Enzyme To Improve Sulfur Removal From Petroleum, Yue Yu Jan 2018

Understanding Inhibition Of A Biodesulfurization Enzyme To Improve Sulfur Removal From Petroleum, Yue Yu

Theses and Dissertations--Chemical and Materials Engineering

The biodesulfurization 4S-pathway is a promising complementary enzymatic approach to remove sulfur from recalcitrant thiophenic derivatives in petroleum products that remain from conventional hydrodesulfurization method without diminishing the calorific value of oil. The final step of this pathway involves the carbon-sulfur bond cleavage from HBPS, and the production of the final products 2-hydroxybiphenyl (HBP) and sulfite, has been recognized as the rate-limiting step, partially as a result of product inhibition. However, the mechanisms and factors responsible for product inhibition in the last step have not been fully understood. In this work, we proposed a computational investigation using molecular dynamic simulations …


Application Of Process Systems Engineering Tools And Methods To Fermentation-Based Biorefineries, Kwabena Darkwah Jan 2018

Application Of Process Systems Engineering Tools And Methods To Fermentation-Based Biorefineries, Kwabena Darkwah

Theses and Dissertations--Chemical and Materials Engineering

Biofuels produced from lignocellulosic biomass via the fermentation platform are sustainable energy alternatives to fossil fuels. Process Systems Engineering (PSE) uses computer-based tools and methods to design, simulate and optimize processes. Application of PSE tools to the design of economic biorefinery processes requires the development of simulation approaches that can be integrated with existing, mature PSE tools used to optimize traditional refineries, such as Aspen Plus. Current unit operation models lack the ability to describe unsteady state fermentation processes, link unsteady state fermentation with in situ separations, and optimize these processes for competing factors (e.g., yield and productivity). This work …