Engineering Commons^™

Computational Predictions Of Heart Failure Drug Effects On Cardiac Fibrosis, Aaron Gardner

Chemical Engineering Undergraduate Honors Theses

The extracellular matrix is a complex system surrounding cells that is crucial to all of the cardiovascular system’s functions. Fibrosis is an excessive accumulation (scarring) of the extracellular matrix. Fibrosis is typically a negative event, and the scarring must be reduced in the heart in order to maintain its functionality. Due to this, simulations are run using the software “Netflux” in order to determine the effects of different heart failure drugs on cardiac fibrosis. The drugs that were simulated were an ACE Inhibitor, BAR Beta Blocker, ARB Blocker, and Entresto. These drugs were simulated over 50 hours at three different …

Integrating Galectin-3 Into A Computational Model Of Cardiac Fibrosis Progression, Adam Pieratt

Chemical Engineering Undergraduate Honors Theses

Cardiac fibrosis, a large contributor to heart failure, is the excessive accumulation of extracellular matrix in response to stress or injury. There are no approved treatments for cardiac fibrosis, and targeting specific species involved creates complex problems for drug development, so a computational model of the cardiac fibroblast signaling network can be used to observe the interactions involved in the progression of cardiac fibrosis. In this paper, a new protein called galectin-3 is integrated into this existing model, and connections are established to expand the coverage of the network. The additions are described, simulated using Netflux biological system simulation software, …

Optimization Of Collagen And Cell Concentrations For Engineered Tissues, Avery Fiser

Chemical Engineering Undergraduate Honors Theses

Improvements regarding the drug discovery process are necessary due to less than 1% of drugs making it from the initial discovery phase to patient treatment in clinics. One method of enhancing this process involves improving the relevance and dependability of in vitro testbeds utilized during pre-clinical testing. Improvement along these factors can provide a more relevant view for eventual drug behavior in patients. This additional relevance can allow for a reduced timeline in drug development for improving patient care. A consistent and morphologically sound baseline engineered tissue is vital to the creation of successful experimental models. Parameters such as cell …

Modeling Sex-Specific Changes In Myocardial Fibrosis, Grace Martin

Chemical Engineering Undergraduate Honors Theses

Heart disease the leading cause of death for both men and women in the United States. Cardiac fibrosis, or accumulation of extracellular matrix proteins in the heart, can occur after a heart attack and increase the risk for further complications. Current treatments for heart disease do not include extracellular matrix regulators, partly due to the complicated signaling network responsible for the production of these proteins. By using a computational model of the signaling network in cardia fibroblasts, the relationship between particular molecules and downstream extracellular matrix production can be examined.

Biological sex is an important factor for cardiac health and …

Biomass Derived Lignin Polymer Modification For Sustainable Chemical Engineering Applications, Samantha Glidewell, Keisha Walters

Chemical Engineering Undergraduate Honors Theses

Lignin is an abundant naturally occurring plant-based polymer that is branched, highly unsaturated, and rich in aliphatic and aromatic hydroxyl groups. Lignin is a significant byproduct of the wood pulp and paper industries; however, it has yet to be widely utilized in commercial applications due to its non-linear structure, broad range of molecular weights, hydrophobicity, high rigidity, and brittleness. Recent investigations into modifying lignin to broaden its potential uses have shown promising results. This thesis explores different modification techniques of the naturally occurring hardwood lignin polymer for specific applications in areas of water treatment and polyurethane (PU) production. The first …

Greenhouse Gas Emissions From Milk Production In The Us, Cailey Cooper

Chemical Engineering Undergraduate Honors Theses

Life cycle assessment is performed to determine the environmental impacts of the life cycle of a product. In this study, the greenhouse gas emissions from milk production in the United States were calculated using a cradle-to-gate analysis. The dairy industry has a noticeable impact on the total greenhouse gas emissions in the US. Performing life cycle assessment provides information about the main emission sources in the life cycle which can spark innovative changes to reduce these emissions. The life cycle assessment was performed using the openLCA software and ReCiPe impact assessment methodology. The results indicated that 1.28 kg of carbon …

Separation Of Organic Acids Through Direct Catalysis From Sugars, Katelyn Robinson

Chemical Engineering Undergraduate Honors Theses

Society relies on plastic products, whether they are single use or durable. A downside of plastic is that the most common type is a product of oil and oil is not only a limited resource but also a climate-damaging resource. Polylactic acid (PLA) is a bio-based, biodegradable plastic. However, the process of converting biomass to polylactic acid polymer has the largest environmental impact of the PLA production process, so alternative methods of conversion are needed (Moretti et al., 2021). The polylactic acid polymer can be made with lactic acid, which can be converted from glucose.

A Teaching Unit Plan For Introducing Engineering In 1st-2nd Grade Classrooms, Claudia Smith

Chemical Engineering Undergraduate Honors Theses

The field of engineering, and specifically chemical engineering, is projected to increase significantly over the next 10 years. Engineering programs require students to have a strong foundation of math and science. Students in the United States are often underprepared to enter these programs, and the majority of high school students are not interested in pursuing a career in the STEM field at all. For this project, a unit teaching plan was created to introduce students to the field of engineering, providing a foundation for their upper-level STEM classes, and encouraging them to consider engineering as a career in the future. …

Study Of The Stability Of Heparin/Collagen Layer-By-Layer Coatings, Hector M. Apodaca Reyes

Chemical Engineering Undergraduate Honors Theses

Pairing heparin with collagen-based medical implants has opened a whole new area of research for enhancing the desired effect of current implants. In fact, heparin (HEP) and collagen (COL) layer-by-layer (LbL) coatings have shown impressive results in forming polyelectrolyte multilayers. It has been already seen on skin grafts, nerve guide conduits (NGCs), and drug delivery devices yielding promising results. Due to being a simple, cost-efficient, and versatile option to fabricate thin biomimetic films, this self-assembly technique is one of the most effective methods to immobilize extracellular matrix (collagen and heparin) onto medical devices and implants. Even though previous studies have …

Comparing Firocoxib And Meloxicam In The Application Of Microneedle Patch For Transdermal Drug Delivery, Ruohan Li

Chemical Engineering Undergraduate Honors Theses

This thesis compares the performance of meloxicam and firocoxib in the aspects of its physical characteristic, chemical compositions, and in-vitro performances for transdermal pain management microneedle patches on farm animals. The microneedle patches are composed of polyvinyl alcohol (PVA), type I collagen (COL), and chitosan (CHI) as base material that carries NSAIDs to achieve therapeutic purposes. Scanning electron microscopy (SEM) was utilized to observe the morphological and physical characteristics of the microneedle patches. Both meloxicam and firocoxib microneedle patches were successfully prepared using the methodology, with organized microneedle distribution and sizing. And Fourier transform infrared spectroscopy (FTIR) confirmed the chemical …

Heat Transfer From Plates, Leanza Trevino

Chemical Engineering Undergraduate Honors Theses

The purpose of this honors thesis is to create an experiment for the CHEG Lab I course. This is a continuation of work done by Alexa Moreno. She created an experiment to model free convection of a horizontal plate. In this report, free and forced convection of a vertical and horizontal plate, respectively are modeled. This report explains the motivation for creating this heat convection experiment, the results of performing the experiment, and provides recommendations for future work on this experiment. Lab handouts are included in the Appendix.

Lignin Copolymer Property Prediction Using Machine Learning, Collin Larsen

Chemical Engineering Undergraduate Honors Theses

Lignin, an abundant biopolymer, is a waste byproduct of the paper and pulp industry. Despite its renewable nature and potential applicability in various products, such as plastics and composites, the development of lignin-based materials has been impeded by the cumbersome, Edisonian process of trial and error. This research proposes a novel approach to forecasting the properties of lignin-based copolymers by utilizing a recurrent neural network (RNN) based on the Keras models previously created by Tao et al. Example units of modified lignin were synthesized via esterification and amination functional group modifications. To increase the efficiency and accuracy of the prediction …

Battery Design, Construction, And Characterization For Small Motor Use Focusing On Anodic Zinc For Electron Flow, Amber Veach

Chemical Engineering Undergraduate Honors Theses

This thesis explores the construction, characterization, and application of anodic zinc batteries for powering a small electric motor for the ChemE Car competition. Two zinc galvanic cell batteries were studied: zinc-carbon and zinc-air batteries. Prototype batteries were constructed and tested for voltage, amperage, and power production. In the zinc-carbon trials, a 3:1 mixture of manganese dioxide and graphite was determined to be the best cathode for power production. The size which allowed for sufficient power while maintaining the smallest footprint on the car was a zinc can six cm tall and two cm in diameter. Analysis of paper zinc-air battery …

A Comparison Of Optical Measurement Methods For The Growth Of S. Cerevisiae, Jackson Black

Chemical Engineering Undergraduate Honors Theses

Genetic engineering of living organisms provides the opportunity to express and harvest different proteins from cell surfaces. Yeast (S. cerevisiae) is one such organism and is capable of being grown on an industrial scale. Cellular concentration is an important parameter to monitor while fermentation processes are underway, in order to control the environment inside the growth medium and maximize yields. Spectrophotometry is a conventional method for measuring concentration, but is limited by a narrow absorbance range, and the need for on-site periodic sampling. A continuous method of measurement, as provided by Bug Labs BE2100 non-invasive biomass monitor, would …

Estimating Toxic Load From Finite-Duration Contaminant Releases In Wind Tunnel Experiments, Patrick B. Jones

Chemical Engineering Undergraduate Honors Theses

When gaseous contaminants are released into the atmosphere said contaminants form clouds that travel in the prevailing wind direction. An individual caught in the downwind path of one such cloud will accumulate a dosage, or toxic load, of said contaminant that is dependent on a multitude of environmental factors. This thesis quantifies unpredictability – or variation – in toxic load measurements using downwind concentration data captured from finite-duration gaseous contaminant releases conducted at set conditions in the Chemical Hazards Research Center ultra-low speed wind tunnel.

Finite-duration releases can be divided into two categories – time-limited steady releases and puffs – …

Measuring Plume Concentration Variations Under Neutral Atmospheric Conditions, Daniel Williams

Chemical Engineering Undergraduate Honors Theses

Hazardous gases are increasingly becoming a large safety concern as the world continues to grow and industrialize. The modeling of when hazardous gases breach containment is an extremely important objective of consequence assessment planning and response. To improve the understanding of the variability inherent in passive gas releases, a test program to demonstrate the variability of gas concentration measurements at different location in a passive gas plume released from an area source in the ultra-low speed wind tunnel at the Chemical Hazards Research Center. A Flame Ionization Detector was used to measure the concentration of the source cloud. Methane was …

Characterizing And Quantifying Shear-Induced Hemolysis In A Hollow Fiber Membrane System, Siddhi Bhat

Chemical Engineering Undergraduate Honors Theses

Clinical studies have shown that patients undergoing renal replacement therapy are more susceptible to developing hemolysis, or the rupturing of red blood cells. Rapid hemolysis can cause symptoms such as anorexia, vomiting, and even death in severe cases. The aim of this study is to identify how shear stress within a hollow fiber membrane impacts the level of hemolysis that occurs. This allows for the optimization of the ultrafiltration membranes that are typically used for hemofiltration treatments. The variables being studied are the radii of hollow fibers, number of fibers, and volumetric flow rate of blood being circulated. Here, we …

Utilization Of Electrodeionization To Separate And Concentrate Cellobionic And Gluconic Acid, Andie Veeder

Chemical Engineering Undergraduate Honors Theses

Biofuel production is currently an expensive and inefficient process with many drawbacks. It is water and land intensive, competes with food production, and requires large energy inputs decreasing its relative sustainability. This paper explores the use of electrodeionization (EDI) to improve the biofuel process by separating and concentrating large, organic sugar acids that are important materials for the production of bioethanol. An EDI device was assembled for the purpose of separating and concentrating gluconic, cellobionic and lactobionic acid. Several trials were conducted and samples were analyzed to determine the success of this experiment. The results for the separation and concentration …

The Environmental And Nutritional Dilemma Of Beef Production And Consumption, Hannah A. Swilling, Stefano De Rosmini, Brooke Lovan

Chemical Engineering Undergraduate Honors Theses

Based on previous studies, it has been stated that beef production and consumption in the United States is detrimental to the environment. However, in depth studies analyzing the change of beef production and consumption, the environmental impacts, the external costs, the lifestyle implications as well as the nutritional, the social and the cultural aspects of beef have not been conducted. The goal of this study is to analyze the multiple aspects of the dilemma over beef production and consumption. This was done through an analysis of beef production and consumption data over the past 60 years to determine how it …

Isolation And Production Of Tandem Collagen Binding Domain From Clostridial Collagenase Colg And Developments In C1q Reagent Production For Future Molecule Characterization Work, Stephanie Beitle

Chemical Engineering Undergraduate Honors Theses

This thesis covers a two part project: the production methods to create a double collagen binding domain molecule with a growth factor for wound healing applications and the development of a new in-house production method for isolating C1q from bovine blood. The wound healing molecule was created using transformation, sonication, and purification before being tested via electrophoresis SDS page and Western blots to confirm the molecule’s presence. The C1q in-house production method utilizes an ultrafiltration flow cell rather than dialysis at a critical point in the process, allowing for researchers to not only be able to use a single small …

Diffusion Of A Salt In An Aqueous Media, Aldaly Pineda Hernandez

Chemical Engineering Undergraduate Honors Theses

Diffusion is defined as the net transfer of a molecule from a high concentration region to a low concentration region. The concept of diffusion is used in a very important process called "desalination." Desalination is a separation process used to reduce the salt content dissolved in brackish water to make it suitable for human consumption, irrigation, and industrial use.

In desalination plants, it is important to monitor the constantly changing salt content of water, partly due to the diffusive effect. The main purpose of this experiment was to study the diffusion of NaCl in water at two NaCl concentrations. The …

Synthesis And Phase Transition Characterization Of Liquid Crystal Membranes With Slit-Like Pores, Isaac Hopwood

Chemical Engineering Undergraduate Honors Theses

Membranes with slit-like pores have been of interest for some time due to their ability to reject smaller particles than traditional cylindrical-pored membranes at the same fluid flux. However, using liquid crystals as a template for this sort of membrane has not been thoroughly investigated. In this study, the liquid crystal mixture of RM257 (2-Methyl-1,4-phenylene bis(4-(3-(acryloyloxy)propoxy)benzoate)) and 5CB (4-Cyano-4'-pentylbiphenyl) for the purpose of manufacturing membranes with slit-like pores, the phase transition behavior of this LC mixture at various mole fractions of RM257, and the impact of mole fraction of RM257 in the liquid crystal (LC) mixture and membrane manufacturing conditions …

Free Convection Heat Transfer From Plates, Alexa Moreno

Chemical Engineering Undergraduate Honors Theses

The purpose of this honors thesis is to create an experiment for the CHEG Lab I course. This report explains the motivation for creating this heat convection experiment, the results of performing the experiment, and provides recommendations for future work on this experiment. Multiple experiments were performed to assess materials and parameters to be investigated. It was determined that a 0.5” plate has smaller percent error and accommodates for the desired timeframe for a Lab I experiment compared to the first plate used (1.5” thickness). Recommendations for expanding on this project include adding experiments using vertical geometry for heat convection …

Analyzing The Surface Chemistry Of Ni-Fe Hydroxide Alloy Nanoparticles As Catalysts For The Oxygen Evolution Reaction By X-Ray Photoelectron Spectroscopy Analysis, Lauren B. Shepard

Chemical Engineering Undergraduate Honors Theses

Water electrolysis has been proposed as a renewable source of hydrogen, a possible replacement to harmful fossil fuels. This process can be broken down into two half reactions, the hydrogen evolution reaction and the oxygen evolution reaction. Because the oxygen evolution reaction has slow kinetics and a high overpotential to overcome, a catalyst is needed to speed up the kinetics and ensure faster and more efficient production of molecular hydrogen. The use of Ni-Fe hydroxide alloy nanoparticles as a catalyst has been shown to significantly improve the efficiency of the reaction by decreasing the overpotential, making the process more energy …

Drug-Facilitated Sexual Assault At The University Of Arkansas, Barrett Weidman

Chemical Engineering Undergraduate Honors Theses

This work was written to fulfill two main purposes. First, to help survivors of Drug-Facilitated Sexual Assault (DFSA) process their experience by compiling the toxicological, pharmacological, and distribution of the three most used date-rape drugs. Second, to gauge the knowledge and interest of University of Arkansas students regarding drug impairments, sexual assault education, and bystander intervention training. A survey was conducted for the latter and revealed that 91.6% of students believe the University’s existing sexual assault prevention education and bystander intervention training have room for improvement. Also, 37.1% of students who have received this education report that the programming does …

Quantification Of Slit-Like Pores Through Using Liquid Crystals As A Template, Dominique Savage

Chemical Engineering Undergraduate Honors Theses

The purpose of this research is to manufacture a membrane with slit-like pores to achieve particle filtration. Slit-like pore membranes are preferred over conventional membranes with cylindrical pores since slit-like pores have two length scales that can be manipulated to better control cut off and flux through the membrane. This project focuses on manufacturing slit-like pore membranes through the use of two liquid crystals, 1,4-bis[4-(6-acryloyloxyhexyloxy)benzoyloxy]-2-methylbenzene (RM257) and 4-Cyano-4′-pentylbiphenyl (5CB). This method for making slit-like pores has not been widely investigated nor has the morphology of the membrane pores and mechanical properties of such a membrane been addressed. It was found …

Identification Of Phosphorous Loading Point Source Facilities To 303(D) Listed Nutrient Impaired Waters Through Watershed Delineation Using Arcgis For Life Cycle Assessment Applications, John Zimmerman

Chemical Engineering Undergraduate Honors Theses

The work done for this project is part of a larger “life cycle assessment (LCA) of novel electrochemical phosphorus recovery technology at the wastewater treatment plant and U.S. watershed scales” (Morrissey 2019). The goal of that LCA is to determine “environmental impacts of implementing electrochemical struvite recovery at the wastewater treatment plant, U.S watershed, and global scales” (Morrissey 2019). This project’s goal is to identify locations deemed more sensitive to eutrophication impacts. The results will be used as part of the life cycle inventory (LCI) accounting for geographically explicit phosphorus flows. The waters identified as impaired were sourced from the …

Machine Learning Representations For Optimization Of Process Systems, Logan Watts

Chemical Engineering Undergraduate Honors Theses

The optimal operation of chemical processes provides the foundation for optimization problems to determine the most effective way to operate or design a given process. Chemical processes can be represented as nonlinear systems of equations with decision variables, resulting in a problem that can be solved through nonlinear solvers. The downfalls of nonlinear solvers create the need for improved methods of finding globally optimal solutions to the design or operation of a chemical process. The project will seek to evaluate the use of artificial neural networks to approximate nonlinear systems of equations for the purpose of optimizing chemical processes. The …

Peptoid-Functionalized Gold Nanoparticles For Zika Virus Envelope Protein Detection, Meagan Olsen

Chemical Engineering Undergraduate Honors Theses

Detection and identification of viral pathogens is essential in providing effective and rapid medical treatment. Well-established detection methods can be expensive, slow, and sometimes unable to provide the needed sensitivity and specificity. The Zika virus is one clinically relevant pathogen that cannot be easily identified due to cross-reactivity with other viruses from the same family. Electrochemical sensors enhanced with peptoid-functionalized gold nanoparticles (AuNPs) are an alternative to traditional techniques that offers rapid, accurate, label-free pathogen detection for point-of-care diagnostics. To this end, a peptoid capable of binding to the Zika virus envelope protein was developed and its binding affinity for …

Garver Industrial Design Project: Designing A Full-Scale Reverse Osmosis Water Treatment Facility For The City Of Lawton, Oklahoma, Kayliana Warden, Marlando Collins, Sandrina Depaz, Reid Eakin, Reed Leasure, Vera Rodriguez

Chemical Engineering Undergraduate Honors Theses

A groundwater treatment facility was designed for Lawton, Oklahoma to address potential water scarcity due to drought conditions in southwest Oklahoma. The facility will produce five million gallons per day (MGD) of treated water. The plant will have the capacity of treating 4,085 gallons per minute of influent water at an 86% recovery. The water to be treated will come from the Arbuckle-Timbered Hills Aquifer. Studies have been conducted around the aquifer to identify the best well site locations.

A centralized treatment facility using reverse osmosis filtration as the main treatment technology has been designed. To prevent reverse osmosis membrane …