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Oxidative Mechanisms In Arterial Distension Injury: Observations Relevant To Restenosis After Angioplasty, Charles F. Babbs, Yuan Zhong
Oxidative Mechanisms In Arterial Distension Injury: Observations Relevant To Restenosis After Angioplasty, Charles F. Babbs, Yuan Zhong
Weldon School of Biomedical Engineering Faculty Working Papers
Background: To explore the hypothesis that tissue iron and reactive oxygen species, including superoxide (O2), mediate acute inflammatory and late hyperplastic responses to vascular injury, we studied experimental overdistension of normal carotid and femoral arteries in dogs. Experimental design: Arterial segments isolated in situ were distended with Ringer solution at 2 atmospheres pressure. In initial experiments the arteries were excised immediately after distension and immersed in diaminobenzidine solutions containing Mn++ ions to initiate histochemical reactions for O2. In other experiments distended arterial segments were reperfused with arterial blood in the presence or absence of the iron chelator, deferoxamine, or the …