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Articles 1 - 6 of 6
Full-Text Articles in Engineering
Quantification Of Intervertebral Disc Strain From High-Resolution Ultrasound Imaging During Dynamic Loading, Diya Sakhrani
Quantification Of Intervertebral Disc Strain From High-Resolution Ultrasound Imaging During Dynamic Loading, Diya Sakhrani
Discovery Undergraduate Interdisciplinary Research Internship
High-resolution ultrasound imaging employs high-frequency sound waves that can be used to noninvasively visualize the structures within the body, facilitating medical diagnosis without the need for open surgery. The widespread utilization of ultrasound is attributed to its affordability, non-invasive characteristics, and use of non-ionizing radiation. Nevertheless, ultrasound is prone to artifacts originating from the surrounding environment, gas-liquid interfaces, or dense tissue. These artifacts are common in ultrasound images and can cause dropout, noise, and degraded resolution. In this study we analyzed intervertebral disc (IVD) strain during two axial compression testing cycles of bovine intervertebral discs with a 2-dimensional direct deformation …
Characterizing Intervertebral Disc Strain Under Dynamic Loading Conditions Using Ultrasound Texture Analysis, Radhika Kulkarni
Characterizing Intervertebral Disc Strain Under Dynamic Loading Conditions Using Ultrasound Texture Analysis, Radhika Kulkarni
Discovery Undergraduate Interdisciplinary Research Internship
Herniated discs in the spine are a significant patient burden, with potential links to lower back and leg discomfort and a considerable impact on daily life. These discs, located between spinal vertebrae, are comprised of the annulus fibrosus (AF) and the nucleus pulposus (NP). Herniations happen when the NP protrudes through a full-thickness annular tear, possibly compressing spinal nerves. The mechanical factors underlying herniated discs are poorly understood, necessitating research into these mechanisms and accessible diagnostic techniques. Our study employs high-resolution ultrasound and texture correlation to quantify strain patterns in intervertebral discs during dynamic loading.
A motion segment from the …
Dielectric/Impedance Spectroscopy For In-Line Measurement Of Moisture Content, Sophie Zhou
Dielectric/Impedance Spectroscopy For In-Line Measurement Of Moisture Content, Sophie Zhou
Discovery Undergraduate Interdisciplinary Research Internship
Pharmaceutical production requires strict moisture content control in order to ensure quality, stability, and efficacy of medicinal products. Moisture content can be manually tested but a rapid and reliable solution for real-time moisture content monitoring was necessary to improve overall efficiency in pharmaceutical manufacturing. This research delved into the practicality of using electrochemical impedance spectroscopy (EIS) as a dependable technique to determine moisture content. By investigating the electrical properties of materials, we established a robust connection between shifts in electrical properties with variations in moisture levels. We employed an equivalent circuit model to unveil the underlying mechanism which provided valuable …
Scanning Electron Microscopy Analysis Of Murine Renal, Aortic, And Cardiac Tissue, Sarah E. Grev, Luke E. Schepers, Jennifer Anderson, Craig J. Goergen
Scanning Electron Microscopy Analysis Of Murine Renal, Aortic, And Cardiac Tissue, Sarah E. Grev, Luke E. Schepers, Jennifer Anderson, Craig J. Goergen
Discovery Undergraduate Interdisciplinary Research Internship
Scanning electron microscopy (SEM) is a tool that provides detailed insight into objects invisible to the human eye. As the name suggests, an electron beam is used to create an image down to the nanometer scale. The beam focuses on the surface of a sample using lenses in the electron column. In this project, we use SEM to study three types of murine tissue. First, we examine the glomerulus, found in the kidney, that is primarily responsible for filtering blood. Following a left renal vein (LRV) stenosis, SEM is used to observe changes to the glomeruli. Differences in the left …
Methods To Study Activity Dependent Protein Synthesis In Autism Spectrum Disorder, Megan Webb, Karin F K Ejendal, Tamara L. Kinzer-Ursem
Methods To Study Activity Dependent Protein Synthesis In Autism Spectrum Disorder, Megan Webb, Karin F K Ejendal, Tamara L. Kinzer-Ursem
Discovery Undergraduate Interdisciplinary Research Internship
It is estimated by the World Health Organization that 1 in 100 children have autism spectrum disorder (ASD), a condition characterized by neurological differences that may impact a person’s learning or behavior. Clinically, ASD symptoms are alleviated with behavioral or pharmacological therapies, however, not all patients respond to these interventions. Deep brain stimulation (DBS) is a promising treatment of Parkinson’s disease that could also be effective in treating ASD. SynGAP1 is a protein involved in neuronal action that is crucial for regulating synaptic plasticity. Mutations in the SYNGAP1 gene causing haploinsufficiency can result in the manifestation of ASD symptoms. This …
Investigation Of Fiber Orientation And Mechanical Properties Of Pyrolysis Recycled Carbon-Fiber Reinforced Thermoset Composite, Reva N. Simmons, Harry Lee, Garam Kim
Investigation Of Fiber Orientation And Mechanical Properties Of Pyrolysis Recycled Carbon-Fiber Reinforced Thermoset Composite, Reva N. Simmons, Harry Lee, Garam Kim
Discovery Undergraduate Interdisciplinary Research Internship
With increasing demand of carbon fiber reinforced fiber thermoset composites, establishing a sustainable cycle for these materials becomes crucial. Pyrolysis is a process of reclaiming carbon fiber from thermoset composites by thermally degrading the polymer at high temperatures allowing the fibers to be extracted. Carbon fiber reclaimed through current pyrolysis processes for thermoset composites typically loses its original shape and orientation, making it difficult to reorganize the fibers. This study investigated the feasibility of maintaining the fiber orientations for continuous fiber reinforced thermoset composite during pyrolysis by stitching the carbon fiber layup to a conformable copper mesh during the manufacturing …