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Full-Text Articles in Engineering
Gold Nanorod-Mediated Photothermolysis Induces Apoptosis To Macrophages Via Damage Of Mitochondria, Ling Tong, Ji-Xin Cheng
Gold Nanorod-Mediated Photothermolysis Induces Apoptosis To Macrophages Via Damage Of Mitochondria, Ling Tong, Ji-Xin Cheng
Birck Poster Sessions
Alterations in macrophage functions contribute to a variety of autoimmune and inflammatory diseases. Diagnosis and eradication of activated macrophages is becoming a valid pharmaceutical target. In this work, gold nanorods conjugated with arginine-rich peptides were applied as theragonosis agents to detect activated macrophages via two-photon luminescence (TPL) and subsequent eradicate through optical hyperthermia. Functionalized gold nanorods could be selectively internalized by activated macrophages in live animals 0.5 h after intraperitoneal (i.p.) injection. Apoptosis of macrophage was induced under proper irradiation conditions to reduce secondary inflammation, through mitochondria-dependent pathway.
Water-Soluble Iron Oxide Nanoparticles For Nanomedicine, Christy L. Cooper, Lisa M. Reece, J Key, Donald E. Bergstrom, James F. Leary
Water-Soluble Iron Oxide Nanoparticles For Nanomedicine, Christy L. Cooper, Lisa M. Reece, J Key, Donald E. Bergstrom, James F. Leary
Birck Poster Sessions
Monodisperse iron oxide nanoparticles (MION) are easily synthesized in organic solvents for industrial applications. However, biological applications require that the particles by readily dispersed in aqueous solutions. To improve their dispersion in aqueous solution, MION particles can be conjugated to water soluble polymers. These water soluble particles can then be used for nanomedicine, which utilizes nanometer scale constructs to treat diseases at the cellular level. Here we report the synthesis of a monodisperse iron oxide nanoparticle construct for breast cancer applications.