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A Comparison Of System Dynamics And Agent-Based Simulationapplied To The Study Of Cellular Receptor Dynamics, Wayne W. Wakeland, Edward J. Gallaher, Louis Macovsky, C. Athena Aktipis

Systems Science Faculty Publications and Presentations

Cellular receptor dynamics are often analyzed using differential equations, making system dynamics (SD) a candidate methodology. In some cases it may be useful to model the phenomena at the biomolecular level, especially when concentrations and reaction probabilities are low and might lead to unexpected behavior modes. In such cases, agent-based simulation (ABS) may be useful. We show the application of both SD and ABS to simulate non-equilibrium ligand-receptor dynamics over a broad range of concentrations, where the probability of interaction varies from low to very low. Both approaches offer much to the researcher and are complementary. We did not find …