Engineering Commons^™

Improving Nano-Drug Delivery By Using Near-Real Time Sensing And Feedback, Pratik Adhikari

Doctoral Dissertations

Personalized medicine, seen as the solution to address the variability among the individuals, is the movement which proposes customization of medical procedures based on the need of the patient during the stages of prevention, diagnosis, treatment, and follow up. As the technology in medicine expands and newer methods of diagnosis and treatment are introduced in the clinic, real time data from the procedures is critical to assess the performance at point of care. Real time feedback, through collection of data at point of care would help make informed clinical decisions, potentially improving the efficacy of the treatment. In this dissertation, …

Nanotechnology And Additive Manufacturing Platforms For Clinical Medicine: An Investigation Of 3d Printing Bioactive Constructs And Halloysite Nanotubes For Drug Delivery And Biomaterials, Jeffery A. Weisman

Doctoral Dissertations

Personalized medicine requires the development of new technologies for controlled or targeted drug delivery. Three-dimensional (3D) printing and additive manufacturing techniques can be used to generate customized constructs for bioactive compound delivery. Nanotechnology in the form of nanoparticles, used as a stand-alone construct or for material enhancements, can significantly improve established biomaterials such as PMMA based bone cements or enable new technology to have enhanced capabilities. Combinations of the technologies can be used in such applications as infectious disease treatments, chemotherapeutic targeted drug delivery or targeted delivery of nearly any bioactive compound.

Chemotherapeutic or antibiotic enhanced 3D printing filaments were …

Radiation Detectors And Sources Enhanced With Micro/Nanotechnology, Chad Michael Whitney

Doctoral Dissertations

The ongoing threat of nuclear terrorism presents major challenges to maintaining national security. Currently, only a small percentage of the cargo containers that enter America are searched for fissionable bomb making materials. This work reports on a multi-channel radiation detection platform enabled with nanoparticles that is capable of detecting and discriminating all types of radiation emitted from fissionable bomb making materials. Typical Geiger counters are limited to detecting only beta and gamma radiation. The micro-Geiger counter reported here detects all species of radiation including beta particles, gamma/X-rays, alpha particles, and neutrons. The multi-species detecting micro-Geiger counter contains a hermetically sealed …

Study Of Interaction Between Indium Species And Dna In The Formation Of Dna -Templated Nanowires, Shivashankar Suryanarayanan

Doctoral Dissertations

A primary goal of semiconductor industry is to improve device performance and capability by downscaling feature size and upscaling packaging density. As optical-lithography, the mainstream technology for microfabrication, is being stretched to its limit, new unconventional fabrication techniques are being explored as alternatives. A "Bottom-up" approach for manufacturing is emerging as an answer to limitations posed by the traditional "Top-down" approach. Nanowires, bearing the potential of being the basic building blocks for such an approach, are gaining tremendous attention in nanoelectronics. Metal nanowires fabricated using DNA as templates have potential for precise control of length, diameter and positioning. However, wires …