Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Engineering
Experimental And Computational Tools For Single Cell Analysis In Cancer Diagnostics, Manibarathi Vaithiyanathan
Experimental And Computational Tools For Single Cell Analysis In Cancer Diagnostics, Manibarathi Vaithiyanathan
LSU Doctoral Dissertations
Substantial evidence shows that cellular heterogeneity commonly exists within an isogenic or clonal population. Whether in isolation or caused through a combination of the above events, cellular heterogeneity can dramatically influence cellular decision making and cell fate, however, this can be masked by the average response from a population. One approach to solve this issue is to analyze a population at the individual cell level. The goal of this work is to develop high-throughput experimental and computational platforms to screen and quantify single cancer cells for specific intracellular enzyme activities. An interdisciplinary approach was taken to 1) better understand the …
Automatic Shoreline Digitization And Mesh Element Sizing For Hydrodynamic Modeling, Henok Kefelegn
Automatic Shoreline Digitization And Mesh Element Sizing For Hydrodynamic Modeling, Henok Kefelegn
LSU Doctoral Dissertations
The first and most critical step in any coastal hydrodynamics and transport process modeling is identifying land-water boundaries. In a coastal wetland, this has always been a challenge due to the complexity of the wetland and lack of efficient methods, calling for efficient and effective methods to extract and digitize the shorelines. While coastline feature extraction has been increasingly researched, its application in hydrodynamic and environmental modeling, without morphological adjustment, remains limited and suboptimal. Further, there has been a paucity of cost-effective, contextually adaptive and high-quality methods to generate meshes, especially for coastal hydrodynamic modeling. This study has developed and …