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- AMSR2 (1)
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- Abdominal aortic aneurysm; Elastin; Matrix proteins; Cell modulus; Matrix metalloproteinases; Nitric oxide; LILAS study (1)
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Articles 1 - 23 of 23
Full-Text Articles in Engineering
An Application Of Bayesian Multilevel Model To Evaluate Variations In Stochastic And Dynamic Transition Of Traffic Conditions, Emmanuel Kidando, Ren Moses, Thobias Sando, Eren Erman Ozguven
An Application Of Bayesian Multilevel Model To Evaluate Variations In Stochastic And Dynamic Transition Of Traffic Conditions, Emmanuel Kidando, Ren Moses, Thobias Sando, Eren Erman Ozguven
Civil and Environmental Engineering Faculty Publications
© 2019, The Author(s). This study seeks to investigate the variations associated with lane lateral locations and days of the week in the stochastic and dynamic transition of traffic regimes (DTTR). In the proposed analysis, hierarchical regression models fitted using Bayesian frameworks were used to calibrate the transition probabilities that describe the DTTR. Datasets of two sites on a freeway facility located in Jacksonville, Florida, were selected for the analysis. The traffic speed thresholds to define traffic regimes were estimated using the Gaussian mixture model (GMM). The GMM revealed that two and three regimes were adequate mixture components for estimating …
Study On Dye-Sensitized Solar Cells Based On Tio2 Composite Nanomaterials, Cuiping Kang, Muhammad Aqeel Ashraf, Yung-Tse Hung
Study On Dye-Sensitized Solar Cells Based On Tio2 Composite Nanomaterials, Cuiping Kang, Muhammad Aqeel Ashraf, Yung-Tse Hung
Civil and Environmental Engineering Faculty Publications
With the continuous development of nanomaterials, how to improve the conversion efficiency of DSSCs has been the focus of scholars. Nano-TiO2 material is a wide bandgap semiconductor with a bandgap of 3.2eV. It exhibits good performance in dye adsorption, charge separation, electron transport, etc., and has good chemical stability and strong acid and alkali resistance. Therefore, it was always the material of choice for the preparation of photoanodes. In this paper, different thicknesses of TiO2 NRs barrier layers were prepared on FTO substrates by solvothermal method and two-step spin coating method, and their electrochemical and photoelectric properties were tested by …
Spark Plasma Sintering Of Low Modulus Titanium-Niobium-Tantalum-Zirconium (Tntz) Alloy For Biomedical Applications, Nicholas Mavros, Taban Larimian, Javier Esqivel, Rajeev Kumar Gupta, Rodrigo Contieri, Tushar Borkar
Spark Plasma Sintering Of Low Modulus Titanium-Niobium-Tantalum-Zirconium (Tntz) Alloy For Biomedical Applications, Nicholas Mavros, Taban Larimian, Javier Esqivel, Rajeev Kumar Gupta, Rodrigo Contieri, Tushar Borkar
Mechanical Engineering Faculty Publications
In metallurgy, titanium has been a staple for biomedical purposes. Its slow toxicity and alloying versatility make it an attractive choice for medical applications. However, studies have shown the difference in elastic modulus between titanium alloys (116 GPa) and human bone (10–40 GPa), which contributes to long term issues with loose hardware fixation. Additionally, long term studies have shown elements such as vanadium and aluminum, which are commonly used in Ti-6Al-4V biomedical alloys, have been linked to neurodegenerative diseases like Alzheimer and Parkinson. Alternative metals known to be less toxic are being explored as replacements for alloying elements in titanium …
Advances In Remote Sensing To Understand Extreme Hydrological Events, Dongkyun Kim, Minha Choi, Jongho Kim, Ungtae Kim
Advances In Remote Sensing To Understand Extreme Hydrological Events, Dongkyun Kim, Minha Choi, Jongho Kim, Ungtae Kim
Civil and Environmental Engineering Faculty Publications
No abstract provided.
Periodic Operation Of A Dynamic Dna Origami Structure Utilizing The Hydrophilic–Hydrophobic Phase‐Transition Of Stimulus‐Sensitive Polypeptides, Marisa A. Goetzfried, Kilian Vogele, Andrea Mückl, Marcus Kaiser, Nolan B. Holland, Friedrich C. Simmel, Tobias Pirzer
Periodic Operation Of A Dynamic Dna Origami Structure Utilizing The Hydrophilic–Hydrophobic Phase‐Transition Of Stimulus‐Sensitive Polypeptides, Marisa A. Goetzfried, Kilian Vogele, Andrea Mückl, Marcus Kaiser, Nolan B. Holland, Friedrich C. Simmel, Tobias Pirzer
Chemical & Biomedical Engineering Faculty Publications
Dynamic DNA nanodevices are designed to perform structure‐encoded motion actuated by a variety of different physicochemical stimuli. In this context, hybrid devices utilizing other components than DNA have the potential to considerably expand the library of functionalities. Here, the reversible reconfiguration of a DNA origami structure using the stimulus sensitivity of elastin‐like polypeptides is reported. To this end, a rectangular sheet made using the DNA origami technique is functionalized with these peptides and by applying changes in salt concentration the hydrophilic–hydrophobic phase transition of these peptides actuate the folding of the structure. The on‐demand and reversible switching of the rectangle …
Alterations In Phenotype And Gene Expression Of Adult Human Aneurysmal Smooth Muscle Cells By Exogenous Nitric Oxide, Kurt Farrell, Phillip Simmers, Gautam Mahajana, Ludovic Boytard, Andrew Camardo, Jyotsna Joshi, Anand Ramamurthi, Florence Pine, Chandrasekhar R. Kothapalli
Alterations In Phenotype And Gene Expression Of Adult Human Aneurysmal Smooth Muscle Cells By Exogenous Nitric Oxide, Kurt Farrell, Phillip Simmers, Gautam Mahajana, Ludovic Boytard, Andrew Camardo, Jyotsna Joshi, Anand Ramamurthi, Florence Pine, Chandrasekhar R. Kothapalli
Chemical & Biomedical Engineering Faculty Publications
Abdominal aortic aneurysms (AAA) are characterized by matrix remodeling, elastin degradation, absence of nitric oxide (NO) signaling, and inflammation, influencing smooth muscle cell (SMC) phenotype and gene expression. Little is known about the biomolecular release and intrinsic biomechanics of human AAA-SMCs. NO delivery could be an attractive therapeutic strategy to restore lost functionality of AAA-SMCs by inhibiting inflammation and cell stiffening. We aim to establish the differences in phenotype and gene expression of adult human AAA-SMCs from healthy SMCs. Based on our previous study which showed benefits of optimal NO dosage delivered via S-Nitrosoglutathione (GSNO) to healthy aortic SMCs, we …
Data-Driven Predictive Maintenance Scheduling Policies For Railways, Pedro Cesar Lopes Gerum, Ayca Altay, Melike Baykal-Gürsoy
Data-Driven Predictive Maintenance Scheduling Policies For Railways, Pedro Cesar Lopes Gerum, Ayca Altay, Melike Baykal-Gürsoy
Supply Chain Management
Inspection and maintenance activities are essential to preserving safety and cost-effectiveness in railways. However, the stochastic nature of railway defect occurrence is usually ignored in literature; instead, defect stochasticity is considered independently of maintenance scheduling. This study presents a new approach to predict rail and geometry defects that relies on easy-to-obtain data and integrates prediction with inspection and maintenance scheduling activities. In the proposed approach, a novel use of risk-averse and hybrid prediction methodology controls the underestimation of defects. Then, a discounted Markov decision process model utilizes these predictions to determine optimal inspection and maintenance scheduling policies. Furthermore, in the …
Estimation Of Gait Kinematics And Kinetics From Inertial Sensor Data Using Optimal Control Of Musculoskeletal Models, Eva Dorschky, Marlies Nitschke, Ann-Kristin Seifer, Antonie J. Van Den Bogert, Bjoern M. Eskofier
Estimation Of Gait Kinematics And Kinetics From Inertial Sensor Data Using Optimal Control Of Musculoskeletal Models, Eva Dorschky, Marlies Nitschke, Ann-Kristin Seifer, Antonie J. Van Den Bogert, Bjoern M. Eskofier
Mechanical Engineering Faculty Publications
Inertial sensing enables field studies of human movement and ambulant assessment of patients. However, the challenge is to obtain a comprehensive analysis from low-quality data and sparse measurements. In this paper, we present a method to estimate gait kinematics and kinetics directly from raw inertial sensor data performing a single dynamic optimization. We formulated an optimal control problem to track accelerometer and gyroscope data with a planar musculoskeletal model. In addition, we minimized muscular effort to ensure a unique solution and to prevent the model from tracking noisy measurements too closely. For evaluation, we recorded data of ten subjects walking …
Synthesis And Secretome Release By Human Bone Marrow Mesenchymal Stem Cell Spheroids Within Three-Dimensional Collagen Hydrogels: Integrating Experiments And Modelling, Jyotsna Joshi, Mohammadreza Dehghan Abnavi, Chandrasekhar R. Kothapalli
Synthesis And Secretome Release By Human Bone Marrow Mesenchymal Stem Cell Spheroids Within Three-Dimensional Collagen Hydrogels: Integrating Experiments And Modelling, Jyotsna Joshi, Mohammadreza Dehghan Abnavi, Chandrasekhar R. Kothapalli
Chemical & Biomedical Engineering Faculty Publications
Myocardial infarction results in loss of cardiac cell types, inflammation, extracellular matrix (ECM) degradation, and fibrotic scar. Transplantation of bone marrow-derived mesenchymal stem cells (BM-MSCs) is being explored as they could differentiate into cardiomyocyte-like cells, integrate into host tissue, and enhance resident cell activity. The ability of these cells to restore lost ECM, remodel the inflammatory scar tissue, and repair the injured myocardium remains unexplored. We here elucidated the synthesis and deposition of ECM (e.g., elastin, sulfated glycosaminoglycans, hyaluronan, collagen type III, laminin, fibrillin, lysyl oxidase, and nitric oxide synthases), matrix metalloproteinases (MMPs) and their inhibitors (TIMPs), and other secretome …
Biophysical And Biomechanical Properties Of Neural Progenitor Cells As Indicators Of Developmental Neurotoxicity, Gautam Mahajan, Moo-Yeal Lee, Chandrasekhar R. Kothapalli
Biophysical And Biomechanical Properties Of Neural Progenitor Cells As Indicators Of Developmental Neurotoxicity, Gautam Mahajan, Moo-Yeal Lee, Chandrasekhar R. Kothapalli
Chemical & Biomedical Engineering Faculty Publications
Conventional in vitro toxicity studies have focused on identifying IC50 and the underlying mechanisms, but how toxicants influence biophysical and biomechanical changes in human cells, especially during developmental stages, remain understudied. Here, using an atomic force microscope, we characterized changes in biophysical (cell area, actin organization) and biomechanical (Young's modulus, force of adhesion, tether force, membrane tension, tether radius) aspects of human fetal brain-derived neural progenitor cells (NPCs) induced by four classes of widely used toxic compounds, including rotenone, digoxin, N-arachidonoylethanolamide (AEA), and chlorpyrifos, under exposure up to 36 h. The sub-cellular mechanisms (apoptosis, mitochondria membrane potential, DNA damage, glutathione …
Incorporating Travel Time Reliability In Predicting The Likelihood Of Severe Crashes On Arterial Highways Using Non-Parametric Random-Effect Regression, Emmanuel Kidando, Ren Moses, Eren Erman Ozguven, Thobias Sando
Incorporating Travel Time Reliability In Predicting The Likelihood Of Severe Crashes On Arterial Highways Using Non-Parametric Random-Effect Regression, Emmanuel Kidando, Ren Moses, Eren Erman Ozguven, Thobias Sando
Civil and Environmental Engineering Faculty Publications
© 2019 The Authors Travel time reliability (TTR) modeling has gain attention among researchers' due to its ability to represent road user satisfaction as well as providing a predictability of a trip travel time. Despite this significant effort, its impact on the severity of a crash is not well explored. This study analyzes the effect of TTR and other variables on the probability of the crash severity occurring on arterial roads. To address the unobserved heterogeneity problem, two random-effect regressions were applied; the Dirichlet random-effect (DRE) and the traditional random-effect (TRE) logistic regression. The difference between the two models is …
Agricultural Drought Assessment Based On Multiple Soil Moisture Products, Jongjin Baik, Muhammad Zohaib, Ungtae Kim, Muhammad Aadil, Minha Choi
Agricultural Drought Assessment Based On Multiple Soil Moisture Products, Jongjin Baik, Muhammad Zohaib, Ungtae Kim, Muhammad Aadil, Minha Choi
Civil and Environmental Engineering Faculty Publications
In this study, we evaluated three soil moisture (SM) products (Advanced Microwave Scanning Radiometer-2 [AMSR2], Advanced SCATterometer [ASCAT], and European Reanalysis Interim [ERA-interim]) across Australia in four climate zones by comparing against the Australian Water Resources Assessment-Landscape (AWRA-L) SM products from July 2012 to June 2017. The ASCAT SM indicated better performance than other SM products over Australia. To evaluate the applicability and reliability for monitoring agricultural drought, an agricultural drought index, the Soil Water Deficit Index, was estimated from three SM products and compared with three commonly-used drought indices (atmospheric water deficit [AWD], Evaporative Stress Index, and Reconnaissance …
Co-Optimization Approach To Post-Storm Recovery For Interdependent Power And Transportation Systems, Yinyin Ge, Lili Du, Hongzing Ye
Co-Optimization Approach To Post-Storm Recovery For Interdependent Power And Transportation Systems, Yinyin Ge, Lili Du, Hongzing Ye
Electrical and Computer Engineering Faculty Publications
The power and transportation systems are urban interdependent critical infrastructures (CIs). During the post-disaster restoration process, transportation mobility and power restoration process are interdependent, and their functionalities significantly affect other well-beings of other urban CIs. Therefore, to enhance the resilience of urban CIs, successful recovery strategies should promote CI function cooperatively and synergistically to distribute goods and services efficiently. This paper develops an integrative framework that addresses the challenges of enhancing the recovery efficiency of urban power and transportation systems in short-term recovery period. Specifically, the post-storm recovery process is considered as a scheduling problem under the constraints representing crew …
Design And Analysis Of Novel Actuation Mechanism With Controllable Stiffness, Erivelton Gualter Dos Santos, Hanz Richter
Design And Analysis Of Novel Actuation Mechanism With Controllable Stiffness, Erivelton Gualter Dos Santos, Hanz Richter
Mechanical Engineering Faculty Publications
Actuators intended for human–machine interaction systems are usually designed to be mechanically compliant. Conventional actuators are not suitable for this purpose due to typically high stiffness. Advanced powered prosthetic and orthotic devices can vary their stiffness during a motion cycle and are power-efficient. This paper proposes a novel actuator design that modulates stiffness by means of a flexible beam. A motorized drive system varies the active length of the cantilever beam, thus achieving stiffness modulation. New large deflection formulation for cantilever beams with rolling contact constraints is used to determine the moment produced by the actuator. To validate the proposed …
Primary Dendrite Trunk Diameter In Al-7wt% Si Alloy Directionally Solidified Aboard The International Space Station, S. R. Upadhyay, Surendra N. Tewari, M. Ghodes, R. N. Grugel, D. R. Poirier, M. Lauer
Primary Dendrite Trunk Diameter In Al-7wt% Si Alloy Directionally Solidified Aboard The International Space Station, S. R. Upadhyay, Surendra N. Tewari, M. Ghodes, R. N. Grugel, D. R. Poirier, M. Lauer
Chemical & Biomedical Engineering Faculty Publications
Under a NASA (National Aeronautics and Space Agency)-ESA (European Space Agency) collaborative research project, MICAST (Microstructure formation in casting of technical alloys under a diffusive and magnetically controlled convection conditions), three Al-7wt% Si samples (MICAST-6, MICAST-7 and MICAST2-12) were directionally solidified at growth speeds varying from 10 to 50 µm s-1 aboard the International Space Station to determine the effect of mitigating convection on the primary dendrite array. The observed primary dendrite trunk diameters during steady-state growth of MICAST samples show a good agreement with predictions from a coarsening based model developed by the authors. The trunk diameters in …
State Estimation For An Agonistic‐Antagonistic Muscle System, Thang Tien Nguyen, Holly Warner, Hung La, Hanieh Mohammadi, Daniel J. Simon, Hanz Richter
State Estimation For An Agonistic‐Antagonistic Muscle System, Thang Tien Nguyen, Holly Warner, Hung La, Hanieh Mohammadi, Daniel J. Simon, Hanz Richter
Electrical and Computer Engineering Faculty Publications
Research on assistive technology, rehabilitation, and prosthetics requires the understanding of human machine interaction, in which human muscular properties play a pivotal role. This paper studies a nonlinear agonistic‐antagonistic muscle system based on the Hill muscle model. To investigate the characteristics of the muscle model, the problem of estimating the state variables and activation signals of the dual muscle system is considered. In this work, parameter uncertainty and unknown inputs are taken into account for the estimation problem. Three observers are presented: a high gain observer, a sliding mode observer, and an adaptive sliding mode observer. Theoretical analysis shows the …
High Order Volumetric Directional Pattern For Video-Based Face Recognition, Almabrok Essa, Vijayan Asari
High Order Volumetric Directional Pattern For Video-Based Face Recognition, Almabrok Essa, Vijayan Asari
Electrical and Computer Engineering Faculty Publications
Describing the dynamic textures has attracted growing attention in the field of computer vision and pattern recognition. In this paper, a novel approach for recognizing dynamic textures, namely, high order volumetric directional pattern (HOVDP), is proposed. It is an extension of the volumetric directional pattern (VDP) which extracts and fuses the temporal information (dynamic features) from three consecutive frames. HOVDP combines the movement and appearance features together considering the nth order volumetric directional variation patterns of all neighboring pixels from three consecutive frames. In experiments with two challenging video face databases, YouTube Celebrities and Honda/UCSD, HOVDP clearly outperformed a set …
Metabolic Cost Calculations Of Gait Using Musculoskeletal Energy Models, A Comparison Study, Anne D. Koelewijn, Dieter Heinrich, Antonie J. Van Den Bogert
Metabolic Cost Calculations Of Gait Using Musculoskeletal Energy Models, A Comparison Study, Anne D. Koelewijn, Dieter Heinrich, Antonie J. Van Den Bogert
Mechanical Engineering Faculty Publications
This paper compares predictions of metabolic energy expenditure in gait using seven metabolic energy expenditure models to assess their correlation with experimental data. Ground reaction forces, marker data, and pulmonary gas exchange data were recorded for six walking trials at combinations of two speeds, 0.8 m/s and 1.3 m/s, and three inclines, -8% (downhill), level, and 8% (uphill). The metabolic cost, calculated with the metabolic energy models was compared to the metabolic cost from the pulmonary gas exchange rates. A repeated measures correlation showed that all models correlated well with experimental data, with correlations of at least 0.9. The model …
Charged Nanoparticles Quench The Propulsion Of Active Janus Colloids, Marola W. Issa, Nicky R. Baumgartner, Mohammed A. Kalil, Shawn D. Ryan, Christopher L. Wirth
Charged Nanoparticles Quench The Propulsion Of Active Janus Colloids, Marola W. Issa, Nicky R. Baumgartner, Mohammed A. Kalil, Shawn D. Ryan, Christopher L. Wirth
Mathematics and Statistics Faculty Publications
Active colloidal particles regularly interact with surfaces in applications ranging from microfluidics to sensing. Recent work has revealed the complex nature of these surface interactions for active particles. Herein, we summarize experiments and simulations that show the impact of charged nanoparticles on the propulsion of an active colloid near a boundary. Adding charged nanoparticles not only decreased the average separation distance of a passive colloid because of depletion attraction as expected but also decreased the apparent propulsion of a Janus colloid to near zero. Complementary agentbased simulations considering the impact of hydrodynamics for active Janus colloids were conducted in the …
Water Pollution In Old Towns Affecting The Environment And Ecological Restoration, Zou Hang, Muhammad Aqeel Ashraf, Yung Tse Hung
Water Pollution In Old Towns Affecting The Environment And Ecological Restoration, Zou Hang, Muhammad Aqeel Ashraf, Yung Tse Hung
Civil and Environmental Engineering Faculty Publications
© 2019 Technoscience Publications. All rights reserved. In order to solve the problem that the traditional activated sludge method is not effective in recovering the ecological process of water pollution in urban areas, the membrane bioreactor-based sewage treatment process was studied experimentally. Two flat-plate ultrafiltration membranes were used to form the ultrafilter tank in the experimental device sampled, and the processes of nitrate cycle and sludge cycle were adopted. Ozonation and granular activated carbon filtration were adopted to treat the micropollutants. After repeated experiments in 17 experimental cycles, the obtained experimental data were analysed, and it was found that under …
Stochastic Cost-Optimization And Risk Assessment Of In Situ Chemical Oxidation For Dense Non-Aqueous Phase Liquid (Dnapl) Source Remediation, Ungtae Kim, Jack C. Parker, Robert C. Borden
Stochastic Cost-Optimization And Risk Assessment Of In Situ Chemical Oxidation For Dense Non-Aqueous Phase Liquid (Dnapl) Source Remediation, Ungtae Kim, Jack C. Parker, Robert C. Borden
Civil and Environmental Engineering Faculty Publications
This study involved development of a computer program to determine optimal design variables for in situ chemical oxidation (ISCO) of dense nonaqueous phase liquid (DNAPL) sites to meet site-wide remediation objectives with minimum life-cycle remediation cost while taking uncertainty in site characterization data and model predictions into consideration. A physically-based ISCO performance model computes field-scale DNAPL dissolution, instantaneous reaction of oxidant with contaminant and with readily oxidizable natural oxidant demand (NOD), second-order kinetic reactions for slowly oxidizable NOD, and time to reach ISCO termination criteria. Remediation cost is computed by coupling the performance model with a cost module. ISCO termination …
Impact Of Sea Surface Temperature And Surface Air Temperature On Maximizing Typhoon Rainfall: Focusing On Typhoon Maemi In Korea, Jeonghyeon Choi, Jeonghoon Lee, Sangdan Kim
Impact Of Sea Surface Temperature And Surface Air Temperature On Maximizing Typhoon Rainfall: Focusing On Typhoon Maemi In Korea, Jeonghyeon Choi, Jeonghoon Lee, Sangdan Kim
Civil and Environmental Engineering Faculty Publications
In this study, the effects of surface air temperature (SAT) and sea surface temperature (SST) changes on typhoon rainfall maximization are analysed. Based on the numerically reproduced Typhoon Maemi, this study tried to maximize the typhoon-induced rainfall by increasing the amount of saturated water vapour in the atmosphere and the amount of water vapour entering the typhoon. Using the Weather Research and Forecasting (WRF) model, which is one of the regional climate models (RCMs), the rainfall simulated by WRF while increasing the SAT and SST to various sizes at initial conditions and boundary conditions of the model was analysed. As …
Application Of Rb/Sr Ratio In Paleo-Climate Inversion, Shupei Ouyang, Muhammad Aqeel Ashraf, Yung-Tse Hung
Application Of Rb/Sr Ratio In Paleo-Climate Inversion, Shupei Ouyang, Muhammad Aqeel Ashraf, Yung-Tse Hung
Civil and Environmental Engineering Faculty Publications
In order to study the intensity of chemical weathering during the formation of sedimentary strata in the site profile, the evolution of climatic environment in the region where the site profile is located was revealed. The rubidium (Rb) and strontium (Sr) values in the rubidium (Rb) and strontium (Sr) were tested and analysed. The Rb/Sr ratio has become an ideal alternative indicator in the study of regional environmental evolution. The Rb value in the strata section of Zhongba site is low, and the average value (calculated based on 202 sample values) is only 80 g/g. The Sr value was higher, …