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Urban Particulate Matter Activates Akt In Human Lung Cells, T. L. Watterson, B. Hamilton, Randy S. Martin, R. A. Coloumb Jr.
Urban Particulate Matter Activates Akt In Human Lung Cells, T. L. Watterson, B. Hamilton, Randy S. Martin, R. A. Coloumb Jr.
Civil and Environmental Engineering Faculty Publications
The normally picturesque Cache Valley in northern Utah is frequently reported to have the worst particulate (PM) air pollution in the United States. Numerous epidemiological studies conducted elsewhere have associated PM exposure to a variety of cardiovascular diseases and early mortality. We have previously shown that Cache Valley PM (CVPM) is pro-inflammatory, through a variety of mechanisms involving the release of inflammatory cytokines, unfolded protein response, ER stress, and C-reactive protein (CRP). This study was undertaken to determine whether Cache Valley PM (CVPM) would activate Akt, an upstream mechanism common to these events. Human lung (BEAS-2B) cells were treated with …
Urban Particulate Matter Casues Er Stress And The Unfolded Protein Response In Human Lung Cells, T. L. Watterson, B. Hamilton, Randy S. Martin, R. A. Coulombe Jr.
Urban Particulate Matter Casues Er Stress And The Unfolded Protein Response In Human Lung Cells, T. L. Watterson, B. Hamilton, Randy S. Martin, R. A. Coulombe Jr.
Civil and Environmental Engineering Faculty Publications
Because of its presumed adverse health effects, particulate air pollution (PM) has received growing attention, but the cellular mechanisms by which PM exerts toxicity are not well elucidated. PM has been associated with early mortality from illnesses that share endoplasmic reticulum (ER) stress as a mechanism of pathogenesis. In this study, we examined whether PM would induce the unfolded protein response (UPR) which is a cellular response to ER stress. Coarse (PM10) and fine (PM2.5) PM was collected from a single location in Northern Utah's Cache Valley during atmospheric inversions occurring in January 2002 and January 2003. Extracts of PM …