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Molecular Dynamics Simulations Of The Spontaneous Deformation And Auxetics Behavior During Tensile Test Of A Nematic Liquid Crystal Elastomer Model, Haoran Wang, Nanang Mahardika
Molecular Dynamics Simulations Of The Spontaneous Deformation And Auxetics Behavior During Tensile Test Of A Nematic Liquid Crystal Elastomer Model, Haoran Wang, Nanang Mahardika
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Nematic liquid crystal elastomers (LCEs) are advanced materials known for their shape-changing capability in response to external stimuli such as heat, light and electromagnetic fields. This makes them excellent candidates for applications like soft robotics and energy harvesting. While studies on their physical behavior have shed light on the complex nonlinear mechanics of LCEs, investigations through all-atom molecular dynamics (MD) simulations remain an underutilized avenue compared to experimental and theoretical analyses. This limited use is primarily due to the lack of well-established frameworks for conducting high-fidelity atomistic simulations of LCEs. To bridge this gap, we introduce an all-atom MD simulation …
Murine Hearing Abr/Dpoae Assessments In Cmv-Infected Mouse Pups Receiving Peritoneal Antivirals Of Gcv, Quercetin+P188, Or A Combination. Controls Include Infected And Untreated And Non-Infected And Treated. Second Dataset Of Antiviral Assay In A Murine Stria Vascularis (Sv) Monolayer Cell Culture, David Britt, Albert Park
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Ganciclovir (GCV) has been shown to be an effective antiviral for the treatment of congenital cytomegalovirus (cCMV) induced sensorineural hearing loss. However, dose-dependent adverse effects (e.g. neutropenia) require strict, burdensome monitoring, limiting GCV use in some patients. Quercetin is a flavonoid with antioxidant properties that has demonstrated antiviral therapy against CMV. Although more benign than GCV, quercetin has limited therapeutic value due to its poor solubility. We previously reported that GCV improves hearing thresholds in a murine model of cCMV. We also noted that solubilizing quercetin with poloxamer 188 (P188) and combining with GCV therapy amplified CMV inhibition in murine …