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2001

Articles 1 - 4 of 4

Full-Text Articles in Engineering

Computed Tomography To Assess Pulmonary Injury Associated With Concurrent Chemo-Radiotherapy For Inoperable Non-Small Cell Lung Cancer, Galit Aviram, Edward Yu, Patricia Tai, Michael Lefcoe Nov 2001

Computed Tomography To Assess Pulmonary Injury Associated With Concurrent Chemo-Radiotherapy For Inoperable Non-Small Cell Lung Cancer, Galit Aviram, Edward Yu, Patricia Tai, Michael Lefcoe

Edward Yu

OBJECTIVE: To characterize serial computed tomography (CT) findings of pulmonary injury after a uniform regimen of concurrent chemo-radiotherapy in inoperable non-small cell lung cancer, and to compare the radiation-induced lung toxicity with other concurrent chemo-radiation regimens. METHODS: Twenty-four patients with advanced non-small cell lung cancer received 2 induction cycles of cisplatin and vinblastine, followed by 2 further cycles of cisplatin and vinblastine, concurrent with 60 Gy radiation at 2 Gy per fraction. Radiation-induced lung injury in the acute and chronic phases was assessed by serial CT scans and compared with preradiation baseline scans. Acute radiation pneumonitis was evaluated using the …

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Alterations In P53 And E2f-1 Function Common To Immortalized Chicken Embryo Fibroblasts, Sakthikumar Ambady, Hyunggee Kim, Seungkwon You, In-Jeong Kim, Linda Foster, James Farris, F Able Ponce Leon, Douglas Foster May 2001

Alterations In P53 And E2f-1 Function Common To Immortalized Chicken Embryo Fibroblasts, Sakthikumar Ambady, Hyunggee Kim, Seungkwon You, In-Jeong Kim, Linda Foster, James Farris, F Able Ponce Leon, Douglas Foster

Sakthikumar Ambady

A number of non-virally and non-chemically immortalized chicken embryo fibroblast (CEF) cells have been established recently in continuous cell culture. All immortal CEF cells tested showed common genetic alterations in the expression patterns of p53 and E2F-1 mRNA and protein which were down- and up-regulated, respectively. The biological effects of differentially regulated p53 and E2F-1 were determined by reporter gene transcriptional activity assays, DNA binding assays, and Northern blot analysis of the expression patterns of down-stream genes. In addition, expression of most of the cyclin genes was up-regulated in immortal CEF cells, which may be associated with the rapid cell …

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Responsible Engineering: The Importance Of Character And Imagination, Michael Pritchard Dec 2000

Responsible Engineering: The Importance Of Character And Imagination, Michael Pritchard

Michael Pritchard

Engineering Ethics literature tends to emphasize wrongdoing, its avoidance, or its prevention. It also tends to focus on identifiable events, especially those that involve unfortunate, sometimes disastrous consequences. This paper shifts attention to the positive in engineering practice; and, as a result, the need for addressing questions of character and imagination becomes apparent.

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Response To ‘Ordinary Reasonable Care Is Not The Minimum For Engineers’ (M. Davis), Michael Pritchard Dec 2000

Response To ‘Ordinary Reasonable Care Is Not The Minimum For Engineers’ (M. Davis), Michael Pritchard

Michael Pritchard

No abstract available.

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