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Articles 1 - 4 of 4
Full-Text Articles in Engineering
Influence Of Select Extracellular Matrix Proteins On Mesenchymal Stem Cell Osteogenic Commitment In Three-Dimensional Contexts, Silvia Becerra-Bayona, Viviana Guiza-Arguello, Xin Qu, Dany Munoz Pinto, Mariah Hahn
Influence Of Select Extracellular Matrix Proteins On Mesenchymal Stem Cell Osteogenic Commitment In Three-Dimensional Contexts, Silvia Becerra-Bayona, Viviana Guiza-Arguello, Xin Qu, Dany Munoz Pinto, Mariah Hahn
Dany J. Munoz Pinto
Growth factors have been shown to be powerful mediators of mesenchymal stem cell (MSC) osteogenic differentiation. However, their use in tissue engineered scaffolds not only can be costly but also can induce undesired responses in surrounding tissues. Thus, the ability to specifically promote MSC osteogenic differentiation in the absence of exogenous growth factors via the manipulation of scaffold material properties would be beneficial. The current work examines the influence of select extracellular matrix (ECM) proteins on MSC osteogenesis toward the goal of developing scaffolds with intrinsically osteoinductive properties. Fibrinogen (FG), fibronectin (FN) and laminin-1 (LN) were chosen for evaluation due …
Relative Impact Of Form-Induced Stress Vs. Uniaxial Alignment On Multipotent Stem Cell Myogenesis, Dany Munoz Pinto, Xin Qu, Loveleena Bansal, Heather Hayenga, Juergen Hahn, Mariah Hahn
Relative Impact Of Form-Induced Stress Vs. Uniaxial Alignment On Multipotent Stem Cell Myogenesis, Dany Munoz Pinto, Xin Qu, Loveleena Bansal, Heather Hayenga, Juergen Hahn, Mariah Hahn
Dany J. Munoz Pinto
Tissue engineering strategies based on multipotent stem cells (MSCs) hold significant promise for the repair or replacement of damaged smooth muscle tissue. To design scaffolds which specifically induce MSC smooth muscle lineage progression requires a deeper understanding of the relative influence of various microenvironmental signals on myogenesis. For instance, MSC myogenic differentiation has been shown to be promoted by increases in active RhoA and FAK, both of which can be induced via increased cell–substrate stress. Separate studies have demonstrated MSC myogenesis to be enhanced by uniaxial cell alignment. The goal of the present study was to compare the impact of …
Osteogenic Potential Of Poly(Ethylene Glycol)–Poly(Dimethylsiloxane) Hybrid Hydrogels, Dany Munoz Pinto, Andrea Jimenez-Vergara, Yaping Hou, Heather Hayenga, Alejandra Rivas, Melissa Grunlan, Mariah Hahn
Osteogenic Potential Of Poly(Ethylene Glycol)–Poly(Dimethylsiloxane) Hybrid Hydrogels, Dany Munoz Pinto, Andrea Jimenez-Vergara, Yaping Hou, Heather Hayenga, Alejandra Rivas, Melissa Grunlan, Mariah Hahn
Dany J. Munoz Pinto
Growth factors have been shown to be potent mediators of osteogenesis. However, their use in tissue-engineered scaffolds not only can be costly but also can induce undesired responses in surrounding tissues. Thus, the ability to specifically induce osteogenic differentiation in the absence of exogenous growth factors through manipulation of scaffold material properties would be desirable for bone regeneration. Previous research indicates that addition of inorganic or hydrophobic components to organic, hydrophilic scaffolds can enhance multipotent stem cell (MSC) osteogenesis. However, the combined impact of scaffold inorganic content and hydrophobicity on MSC behavior has not been systematically explored, particularly in three-dimensional …
A Comparative Study Of The Cytotoxicity And Corrosion Resistance Of Nickel–Titanium And Titanium–Niobium Shape Memory Alloys, Rebecca Mcmahon, Ji Ma, Stanislav Verkhoturov, Dany Munoz Pinto, Ibrahim Karaman, Felix Rubitschek, Hans Maier, Mariah Hahn
A Comparative Study Of The Cytotoxicity And Corrosion Resistance Of Nickel–Titanium And Titanium–Niobium Shape Memory Alloys, Rebecca Mcmahon, Ji Ma, Stanislav Verkhoturov, Dany Munoz Pinto, Ibrahim Karaman, Felix Rubitschek, Hans Maier, Mariah Hahn
Dany J. Munoz Pinto
Nickel–titanium (NiTi) shape memory alloys (SMAs) are commonly used in a range of biomedical applications. However, concerns exist regarding their use in certain biomedical scenarios due to the known toxicity of Ni and conflicting reports of NiTi corrosion resistance, particularly under dynamic loading. Titanium–niobium (TiNb) SMAs have recently been proposed as an alternative to NiTi SMAs due to the biocompatibility of both constituents, the ability of both Ti and Nb to form protective surface oxides, and their superior workability. However, several properties critical to the use of TiNb SMAs in biomedical applications have not been systematically explored in comparison with …