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Full-Text Articles in Engineering
Effect Of Grafting Rgd And Bmp-2 Protein-Derived Peptides To A Hydrogel Substrate On Osteogenic Differentiation Of Marrow Stromal Cells, Xuezhong He, Junya Ma, Esmaiel Jabbari
Effect Of Grafting Rgd And Bmp-2 Protein-Derived Peptides To A Hydrogel Substrate On Osteogenic Differentiation Of Marrow Stromal Cells, Xuezhong He, Junya Ma, Esmaiel Jabbari
Esmaiel Jabbari
No abstract provided.
The Role Of Filler-Matrix Interaction On Viscoelastic Response Of Biomimetic Nanocomposite Hydrogels, Alireza Sarvestani, Xuezhong He, Esmaiel Jabbari
The Role Of Filler-Matrix Interaction On Viscoelastic Response Of Biomimetic Nanocomposite Hydrogels, Alireza Sarvestani, Xuezhong He, Esmaiel Jabbari
Esmaiel Jabbari
The effect of a glutamic acid (negatively charged) peptide (Glu6), which mimics the terminal region of the osteonectin glycoprotein of bone on the shear modulus of a synthetic hydorgel/apatite nanocomposite, was investigated. One end of the synthesized peptide was functionalized with an acrylate group (Ac-Glu6) to covalently attach the peptide to the hydrogel phase of the composite matrix. The addition of Ac-Glu6 to hydroxyapatite (HA) nanoparticles (50 nm in size) resulted in significant reinforcement of the shear modulus of the nanocomposite (~100% increase in elastic shear modulus). The reinforcement effect of the Glu6 peptide, a sequence in the terminal region …
A Molecular Dynamics Simulation Of The Stability-Limited Growth Mechanism Of Peptide-Mediated Gold-Nanoparticle Synthesis, Jing Yu, Matthew Becker, Gustavo Carri
A Molecular Dynamics Simulation Of The Stability-Limited Growth Mechanism Of Peptide-Mediated Gold-Nanoparticle Synthesis, Jing Yu, Matthew Becker, Gustavo Carri
Gustavo A. Carri
The bindingof a 12-residue peptide to a Au {111} surface and nanoparticles with different sizes result in various equilibrium structures and stabilities due to the surface morphology. The equilibrium structures are represented by the distance of peptide atoms to Au surface and the stabilities of peptide residues are represented by the average change of dihedral angles.
Quantification Of The Binding Affinity Of A Specific Hydroxyapatite Binding Peptide, Michael Weiger, Jung Park, Marc Roy, Christopher Stafford, Alamgir Karim, Matthew Becker
Quantification Of The Binding Affinity Of A Specific Hydroxyapatite Binding Peptide, Michael Weiger, Jung Park, Marc Roy, Christopher Stafford, Alamgir Karim, Matthew Becker
Alamgir Karim
The genesis of bone and teeth involves highly coordinated processes, which involve multiple cell types and proteins that direct the nucleation and crystallization of inorganic hydroxyapatite (HA). Recent studies have shown that peptides mediate the nucleation process, control HA microstructure or even inhibit HA mineralization. Using phage display technology, a short peptide was identified that binds to crystalline HA and to HA-containing domains of human teeth with chemical and morphological specificity. However, the binding affinity and specific amino acids that significantly contribute to this interaction require further investigation. In this study, we employ a microfluidic chip based surface plasmon resonance …