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Full-Text Articles in Engineering
Radiosensitisation Enhancement Effect Of Brudr And Ta2o5 Nsps In Combination With 5-Fluorouracil Antimetabolite In Kilovoltage And Megavoltage Radiation, Marjorie Mcdonald, Sianne Oktaria, Konstantin K. Konstantinov, Anatoly B. Rosenfeld, Michael L. F Lerch, Stephanie Corde, Moeava Tehei
Radiosensitisation Enhancement Effect Of Brudr And Ta2o5 Nsps In Combination With 5-Fluorouracil Antimetabolite In Kilovoltage And Megavoltage Radiation, Marjorie Mcdonald, Sianne Oktaria, Konstantin K. Konstantinov, Anatoly B. Rosenfeld, Michael L. F Lerch, Stephanie Corde, Moeava Tehei
Faculty of Engineering and Information Sciences - Papers: Part B
This article demonstrates in vitro a synergistic effect on 9L gliosarcoma cells when exposed to bromodeoxyuridine (BrUdR) and a low concentration (100 times lower than the IC50) of 5-Fluorouracil (5-FU), in combination with x-ray irradiation. The synergy is brought about by several important factors including the x-ray beam energy, atomic number of the BrUdR (Z = 35), effectiveness of 5-FU in reducing the available repair processes and distribution of the BrUdR in and around the 9L cells (32% of the total substitution of BrUdR for thymidine into nucleus DNA). Our results show that the synergistic effect, evident in an optimised …