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Polo-Like Kinase 1 Inhibitor Bi6727 Sensitizes 9l Gliosarcoma Cells To Ionizing Irradiation, Nan Li, Elette Engels, Jeremy A. Davis, Andrew Dipuglia, Sarah Vogel, Michael Valceski, Anatoly B. Rosenfeld, Michael L. F Lerch, Stephanie Corde, Moeava Tehei
Polo-Like Kinase 1 Inhibitor Bi6727 Sensitizes 9l Gliosarcoma Cells To Ionizing Irradiation, Nan Li, Elette Engels, Jeremy A. Davis, Andrew Dipuglia, Sarah Vogel, Michael Valceski, Anatoly B. Rosenfeld, Michael L. F Lerch, Stephanie Corde, Moeava Tehei
Faculty of Engineering and Information Sciences - Papers: Part B
Surgery, chemotherapy and radiotherapy remain as the major treatment strategies for cancers. Some agents such as anti-cancer drugs have capacity to enhance the radiation sensitivity of cancer cells at G2/M phase, leading to an improved radiotherapeutic efficacy. BI6727 is an ATP-competitive pololike kinase 1 (Plk 1)inhibitor and an anti-cancer drug. Using the radio-resistant 9L rat gliosarcoma cells as model, we examined the effect of BI6727 on cell growth and assessed the chemoradiotherapeutic efficiency between 150 kVp conventional irradiation (dose rate of 0.76 Gy min−1 ) and 66 keV synchrotron x-ray broad beam irradiation (dose rate of 46 Gy s−1). Our …