Engineering Commons^™

The Effects Of Joule Heating On Electric-Driven Microfluidic Flow, Alexander P. Spitzer

Journal of the South Carolina Academy of Science

This study sought out to more clearly understand the relationship between Joule heating and fluid flow in microfluidic environments, and more specifically, under what circumstances would the fluid flow in the device possibly hinder an experiment being run on it. It had been previous theorised that an electric field may produce turbulence and even vortices within the fluid, which this study attempted to reproduce. Several variables were tested, namely insulating and conducting fluids, higher and lower AC voltages, Newtonian vs. non-Newtonian fluids, and higher and lower DC voltages. A correlation between these variables and turbulent flow was found, with more …

Reconstructing Yeasts Phylogenies And Ancestors From Whole Genome Data, Bing Feng, Yu Ling, Lingxi Zhou, Roufan Xia, Fei Hu, Chao Liu

Faculty Publications

Phylogenetic studies aim to discover evolutionary relationships and histories. These studies are based on similarities of morphological characters and molecular sequences. Currently, widely accepted phylogenetic approaches are based on multiple sequence alignments, which analyze shared gene datasets and concatenate/coalesce these results to a final phylogeny with maximum support. However, these approaches still have limitations, and often have conflicting results with each other. Reconstructing ancestral genomes helps us understand mechanisms and corresponding consequences of evolution. Most existing genome level phylogeny and ancestor reconstruction methods can only process simplified real genome datasets or simulated datasets with identical genome content, unique genome markers, …

Reconstructing Yeasts Phylogenies And Ancestors From Whole Genome Data, Bing Feng, Yu Lin, Lingxi Zhou, Yan Guo, Robert Friedman, Roufan Xia, Chao Liu, Jijun Tang

Faculty Publications

Phylogenetic studies aim to discover evolutionary relationships and histories. These studies are based on similarities of morphological characters and molecular sequences. Currently, widely accepted phylogenetic approaches are based on multiple sequence alignments, which analyze shared gene datasets and concatenate/coalesce these results to a final phylogeny with maximum support. However, these approaches still have limitations, and often have conflicting results with each other. Reconstructing ancestral genomes helps us understand mechanisms and corresponding consequences of evolution. Most existing genome level phylogeny and ancestor reconstruction methods can only process simplified real genome datasets or simulated datasets with identical genome content, unique genome markers, …

Improvement Of Phylogenetic Method To Analyze Compositional Heterogeneity, Zehua Zhang, Kecheng Guo, Gaofeng Pan, Jijun Tang, Fei Guo

Faculty Publications

Background: Phylogenetic analysis is a key way to understand current research in the biological processes and detect theory in evolution of natural selection. The evolutionary relationship between species is generally reflected in the form of phylogenetic trees. Many methods for constructing phylogenetic trees, are based on the optimization criteria. We extract the biological data via modeling features, and then compare these characteristics to study the biological evolution between species.

Results: Here, we use maximum likelihood and Bayesian inference method to establish phylogenetic trees; multi-chain Markov chain Monte Carlo sampling method can be used to select optimal phylogenetic tree, resolving local …

An Ameliorated Prediction Of Drug–Target Interactions Based On Multi-Scale Discrete Wavelet Transform And Network Features, Cong Shen, Yijie Ding, Jijun Tang, Xinying Xu, Fei Guo

Faculty Publications

The prediction of drug–target interactions (DTIs) via computational technology plays a crucial role in reducing the experimental cost. A variety of state-of-the-art methods have been proposed to improve the accuracy of DTI predictions. In this paper, we propose a kind of drug–target interactions predictor adopting multi-scale discrete wavelet transform and network features (named as DAWN) in order to solve the DTIs prediction problem. We encode the drug molecule by a substructure fingerprint with a dictionary of substructure patterns. Simultaneously, we apply the discrete wavelet transform (DWT) to extract features from target sequences. Then, we concatenate and normalize the target, drug, …

An Ensemble Deep Convolutional Neural Network Model With Improved D-S Evidence Fusion For Bearing Fault Diagnosis, Shaobo Li, Guoka Liu, Xianghong Tang, Jianguang Lu, Jianjun Hu

Faculty Publications

Intelligent machine health monitoring and fault diagnosis are becoming increasingly important for modern manufacturing industries. Current fault diagnosis approaches mostly depend on expert-designed features for building prediction models. In this paper, we proposed IDSCNN, a novel bearing fault diagnosis algorithm based on ensemble deep convolutional neural networks and an improved Dempster–Shafer theory based evidence fusion. The convolutional neural networks take the root mean square (RMS) maps from the FFT (Fast Fourier Transformation) features of the vibration signals from two sensors as inputs. The improved D-S evidence theory is implemented via distance matrix from evidences and modified Gini Index. Extensive evaluations …

Bird's Eye View: Cooperative Exploration By Ugv And Uav, Shannon Hood

Theses and Dissertations

This paper proposes a solution to the problem of cooperative exploration using an Unmanned Ground Vehicle (UGV) and an Unmanned Aerial Vehicle (UAV). More specifically, the UGV navigates through the free space, and the UAV provides enhanced situational awareness via its higher vantage point. The motivating application is search and rescue in a damaged building. A camera atop the UGV is used to track a fiducial tag on the underside of the UAV, allowing the UAV to maintain a fixed pose relative to the UGV. Furthermore, the UAV uses its front facing camera to provide a birds-eye-view to the remote …

Using Polymerization, Glass Structure, And Quasicrystalline Theory To Produce High Level Radioactive Borosilicate Glass Remotely: A 20+ Year Legacy, Carol M. Jantzen

Journal of the South Carolina Academy of Science

Vitrification is currently the most widely used technology for the treatment of high level radioactive wastes (HLW) throughout the world. Most of the nations that have generated HLW are immobilizing in borosilicate glass. One of the primary reasons that glass has become the most widely used immobilization media is the relative simplicity of the vitrification process, e.g. melt a highly variable waste with some glass forming additives such as SiO₂ and B₂O₃ in the form of a premelted frit and pour the molten mixture into a stainless steel canister. Seal the canister before moisture can enter …

A Machine Learning Approach For Enhancing Security And Quality Of Service Of Optical Burst Switching Networks, Adel Dabash A. Rajab

Theses and Dissertations

The Optical Bust Switching (OBS) network has become one of the most promising switching technologies for building the next-generation of internet backbone infrastructure. However, OBS networks still face a number of security and Quality of Service (QoS) challenges, particularly from Burst Header Packet (BHP) flooding attacks. In OBS, a core switch handles requests, reserving one of the unoccupied channels for incoming data bursts (DB) through BHP. An attacker can exploit this fact and send malicious BHP without the corresponding DB. If unresolved, threats such as BHP flooding attacks can result in low bandwidth utilization, limited network performance, high burst loss …

Blind Change Point Detection And Regime Segmentation Using Gaussian Process Regression, Sourav Das

Theses and Dissertations

Time-series analysis is used heavily in modeling and forecasting weather, economics, medical data as well as in various other fields. Change point detection (CPD) means finding abrupt changes in the time-series when the statistical property of a certain part of it starts to differ. CPD has attracted a lot of attention in the artificial intelligence, machine learning and data mining communities. In this thesis, a novel CPD algorithm is introduced for segmenting multivariate time-series data. The proposed algorithm is a general pipeline to process any high dimensional multivariate time-series data using nonlinear non-parametric dynamic system. It consists of manifold learning …

Underwater Cave Mapping And Reconstruction Using Stereo Vision, Nicholas Weidner

Theses and Dissertations

This work presents a systematic approach for 3-D mapping and reconstruction of underwater caves. Exploration of underwater caves is very important for furthering our understanding of hydrogeology, managing efficiently water resources, and advancing our knowledge in marine archaeology. Underwater cave exploration by human divers however, is a tedious, labor intensive, extremely dangerous operation, and requires highly skilled people. As such, it is an excellent fit for robotic technology. The proposed solution employs a stereo camera and a video-light. The approach utilizes the intersection of the cone of video-light with the cave boundaries resulting in the construction of a wire frame …

Mobile Application For Shipping Goods For Individuals And Truckers In India, Sendurr Selvaraj

Theses and Dissertations

India is a vast country with majority of its cities and towns connected through roads. Road transportation contributes to 86% share of the freight transport of the country with trucking companies dominating the entire space. With growing economy and demands raising, the quality of service of the trucking company remains poor. The major reasons are unorganized practice and lack of transparency. Moreover, limited access for customers to reach out to truckers to transport their goods.

This thesis aims to create a platform for customers and truckers to realize their needs with a help of a mobile application. Customers can search …

Improving Peptide Identification By Considering Ordered Amino Acid Usage, Ahmed Al-Qurri

Theses and Dissertations

Proteomics has made major progress in recent years after the sequencing of the genomes of a substantial number of organisms. A typical method for identifying peptides uses a database of peptides identified using tandem mass spectrometry (MS/MS). The profile of accurate mass and elution time (AMT) for peptides that need to be identified will be compared with this database. Restricting the search to those peptides detectable by MS will reduce processing time and more importantly increase accuracy. In addition, there are significant impacts for clinical studies. Proteotypic peptides are those peptides in a protein sequence that are most likely to …

Investigate Genomic 3d Structure Using Deep Neural Network, Yan Zhang

Theses and Dissertations

The 3D structures of the chromosomes play fundamental roles in essential cellular functions, e.g., gene regulation, gene expression, evolution and Hi-C technique provides the interaction density between loci on chromosomes. In this dissertation, we developed multiple algorithms, focusing the deep learning approach, to study the Hi-C datasets and the genomic 3D structures.

Building 3D structure of the genome one of the most critical purpose of the Hi-C technique. Recently, several approaches have been developed to reconstruct the 3D model of the chromosomes from HiC data. However, all of the methods are based on a particular mathematical model and lack of …

Improving Facial Action Unit Recognition Using Convolutional Neural Networks, Shizhong Han

Theses and Dissertations

Recognizing facial action units (AUs) from spontaneous facial expression is a challenging problem, because of subtle facial appearance changes, free head movements, occlusions, and limited AU-coded training data. Most recently, convolutional neural networks (CNNs) have shown promise on facial AU recognition. However, CNNs are often overfitted and do not generalize well to unseen subject due to limited AU-coded training images. In order to improve the performance of facial AU recognition, we developed two novel CNN frameworks, by substituting the traditional decision layer and convolutional layer with the incremental boosting layer and adaptive convolutional layer respectively, to recognize the AUs from …