Engineering Commons^™

Synthesis And Characterization Of 4,6-Protected Glucosamine Derivatives And Branched Glycoconjugates, Jonathan Bietsch

Chemistry & Biochemistry Theses & Dissertations

Low molecular weight gelators (LMWGs) are small molecules that self-assemble in appropriate solvents to form three dimensional networks that immobilize the solvent, creating a supramolecular gel. The self-assembly of LMWGs occurs through non-covalent interactions such as hydrogen bonding, aromatic interactions, donor-acceptor interactions, Van der Waals interactions, hydrophobic forces, halogen bonding, etc. Due to self-assembly occurring through reversible non-covalent interactions, supramolecular gels can undergo a gel to solution transformation. Because of this, these materials can be sensitive to external stimuli such as temperature changes, pH changes, and other stimuli that effect non-covalent interactions. This makes the synthesis of LMWG’s an appealing …

Spatiotemporal Variations Of Precipitation And Climate-Resilient Structure Design In Virginia, Xiaomin Yang

Civil & Environmental Engineering Theses & Dissertations

How to consider effects of climate change on the design and management of hydrology related infrastructure is crucial but remains a challenge for sustaining resilient society. To address this challenge, existing hydrologic design procedures may need to be revised and/or redeveloped to take into account the precipitation non-stationarity resulting from climate change. Using the state of Virginia as a testbed and advanced statistical techniques such as nonparametric test, spatial autocorrelation, linear regression, distribution fitting, and spatial interpolation, this dissertation developed an innovative framework to detect the historical spatiotemporal variations of various precipitation characteristics, namely maximum precipitation intensity, precipitation amount, simple …

Data-Driven Operational And Safety Analysis Of Emerging Shared Electric Scooter Systems, Qingyu Ma

Computational Modeling & Simulation Engineering Theses & Dissertations

The rapid rise of shared electric scooter (E-Scooter) systems offers many urban areas a new micro-mobility solution. The portable and flexible characteristics have made E-Scooters a competitive mode for short-distance trips. Compared to other modes such as bikes, E-Scooters allow riders to freely ride on different facilities such as streets, sidewalks, and bike lanes. However, sharing lanes with vehicles and other users tends to cause safety issues for riding E-Scooters. Conventional methods are often not applicable for analyzing such safety issues because well-archived historical crash records are not commonly available for emerging E-Scooters.

Perceiving the growth of such a micro-mobility …

Joint Linear And Nonlinear Computation With Data Encryption For Efficient Privacy-Preserving Deep Learning, Qiao Zhang

Electrical & Computer Engineering Theses & Dissertations

Deep Learning (DL) has shown unrivalled performance in many applications such as image classification, speech recognition, anomalous detection, and business analytics. While end users and enterprises own enormous data, DL talents and computing power are mostly gathered in technology giants having cloud servers. Thus, data owners, i.e., the clients, are motivated to outsource their data, along with computationally-intensive tasks, to the server in order to leverage the server’s abundant computation resources and DL talents for developing cost-effective DL solutions. However, trust is required between the server and the client to finish the computation tasks (e.g., conducting inference for the newly-input …

Empirical Modeling Of Tilt-Rotor Aerodynamic Performance, Michael C. Stratton

Mechanical & Aerospace Engineering Theses & Dissertations

There has been increasing interest into the performance of electric vertical takeoff and landing (eVTOL) aircraft. The propellers used for the eVTOL propulsion systems experience a broad range of aerodynamic conditions, not typically experienced by propellers in forward flight, that includes large incidence angles relative to the oncoming airflow. Formal experiment design and analysis techniques featuring response surface methods were applied to a subscale, tilt-rotor wind tunnel test for three, four, five, and six blade, 16-inch diameter, propeller configurations in support of development of the NASA LA-8 aircraft. Investigation of low-speed performance included a maximum speed of 12 m/s and …

Numerical Calculation Of Losses Of Trapped Vortices Under Strong Rf Meissner Current And Dc Superheating Field In Type Ii Superconductors, Walive Pathiranage Manula Randhika Pathirana

Physics Theses & Dissertations

Research on the vortex dynamics and enhancing of superheating field in superconductors has attracted much attention in accelerator physics community to develop next-generation high-performance accelerator cavities. However, the extreme dynamics of curvilinear elastic vortices driven by very strong currents close to the depairing limit or superheating field of a superconductor with a nanostructured surface has not been well understood. We calculated the superheating field H_sh and critical momentum kc characterizing the wavelength of the instability λ_m of the Meissner state to flux penetration by solving numerically the Ginzburg-Landau equations. A bulk superconductor, superconductor with the inhomogeneous surface disorder …

Molecular Dynamics Simulations Of Ion Transport Through Electrically Stressed Biological Membranes, Federica Castellani

Biomedical Engineering Theses & Dissertations

The cell membrane is a selectively permeable barrier that controls the transport of ions, molecules, and other materials into and out of a cell. The manipulation of the cell membrane permeability is the basis for several biotechnological and biomedical applications, including electroporation. Electroporation (or electropermeabilization) occurs when the application of an external electric pulse causes water intrusion into the membrane interior and the formation of conductive transmembrane electropores. These electropores allow drugs, genetic material, and other normally impermeant molecules to enter a cell. Despite years of study, the complex mechanisms underlying this process are still not well understood. Molecular dynamics …

Electrohydrodynamic Simulations Of Capsule Deformation Using A Dual Time-Stepping Lattice Boltzmann Scheme, Charles Leland Armstrong

Mathematics & Statistics Theses & Dissertations

Capsules are fluid-filled, elastic membranes that serve as a useful model for synthetic and biological membranes. One prominent application of capsules is their use in modeling the response of red blood cells to external forces. These models can be used to study the cell’s material properties and can also assist in the development of diagnostic equipment. In this work we develop a three dimensional model for numerical simulations of red blood cells under the combined influence of hydrodynamic and electrical forces. The red blood cell is modeled as a biconcave-shaped capsule suspended in an ambient fluid domain. Cell deformation occurs …

The Development Of Novel Carbohydrate-Based Gelators And Their Applications As Advanced Soft Materials, Joedian Morris

Chemistry & Biochemistry Theses & Dissertations

Low molecular weight gelators (LMWGs) are attractive molecules that have been explored extensively due to their practical applications in many disciplines. These small molecules self-assemble forming solid-like gels via three-dimensional cross-linked networks with the solvent as the key component within the matrix. Carbohydrate-based LMWGs are small molecules that can form solid-like gels in water, organic solvents, and aqueous solutions. They have great potential to be utilized in different applications because carbohydrates are biocompatible and can be made from easily accessible and renewable resources. Designing gelators is still a challenge within the field, even though researchers have developed tools to predict …

Rainfall-Runoff Mechanisms And Flood Mitigation In A Coastal Watershed With Numerous Wetlands And Ponds, Homa Jalaeian Taghadomi

Civil & Environmental Engineering Theses & Dissertations

This study analyzed mechanisms of flooding in Blackwater River Watershed, located in coastal Virginia and hydraulically connected with mid-Atlantic Ocean. The analysis was based on the examination and simulation of the rainfall-runoff relationship, and such an analysis is very important for conventional water resource management and dealing with hydrologic extremes (e.g., floods and droughts, as well as ecological and pollution discharges). The rainfall-runoff relationship is a quantitative description of the hydrologic cycle, a dynamic process that can be interactively influenced by various factors, namely climate, topography, soils, land use and land cover, and land management practice.

In the past 60 …

High-Order Positivity-Preserving L2-Stable Spectral Collocation Schemes For The 3-D Compressible Navier-Stokes Equations, Johnathon Keith Upperman

Mathematics & Statistics Theses & Dissertations

High-order entropy stable schemes are a popular method used in simulations with the compressible Euler and Navier-Stokes equations. The strength of these methods is that they formally satisfy a discrete entropy inequality which can be used to guarantee L₂ stability of the numerical solution. However, a fundamental assumption that is explicitly or implicitly used in all entropy stability proofs available in the literature for the compressible Euler and Navier-Stokes equations is that the thermodynamic variables (e.g., density and temperature) are strictly positive in the entire space{time domain considered. Without this assumption, any entropy stability proof for a numerical scheme …

Development And Applications Of Adjoint-Based Aerodynamic And Aeroacoustic Multidisciplinary Optimization For Rotorcraft, Ramiz Omur Icke

Mechanical & Aerospace Engineering Theses & Dissertations

Urban Air Mobility (UAM) is one of the most popular proposed solutions for alleviating traffic problems in populated areas. In this context, the proposed types of vehicles mainly consist of rotors and propellers powered by electric motors. However, those rotary-wing components can contribute excessively to noise generation. Therefore, a significant noise concern emerges due to urban air vehicles in or around residential areas. Reducing noise emitted by air vehicles is critically important to improve public acceptance of such vehicles for operations in densely populated areas.

Two main objectives of the present dissertation are: (1) to expand the multidisciplinary optimization to …

A Digital One Degree Of Freedom Model Of An Electromagnetic Position Sensor, Michelle Elizabeth Weinmann

Mechanical & Aerospace Engineering Theses & Dissertations

The purpose of this project was to improve an existing system currently in use by NASA Langley Research Center (LaRC). The 6-inch Magnetic Suspension and Balance System (MSBS) built at MIT is operational with control in three degrees of freedom, with two additional degrees of freedom exhibiting passive stability. The means for measuring model displacement within the magnetic environment is an Electromagnetic Position Sensor (EPS), consisting of excitation coils at 20 kHz and multiple sets of pickup coils. The pickup coil voltages are proportional to model displacement in each degree of freedom. However, the EPS electronic signal processing system is …

Wiener-Fliess Composition Of Formal Power Series: Additive Static Feedback And Shuffle Rational Series, Subbarao Venkatesh Guggilam

Electrical & Computer Engineering Theses & Dissertations

The problem statement for this dissertation is two-fold. The first problem considered is when does a Chen-Fliess series in an additive static feedback connection with a formal static map yield a closed-loop system with a Chen-Fliess series expansion? This work proves that such a closed-loop system always has a Chen-Fliess series representation. Furthermore, an algorithm based on the Hopf algebras for the shuffle group and the dynamic output feedback group is designed to compute the generating series of the closed-loop system. It is proved that the additive static feedback connection preserves local convergence and relative degree, but a counterexample shows …

Quantifying Cyber Risk By Integrating Attack Graph And Impact Graph, Omer F. Keskin

Engineering Management & Systems Engineering Theses & Dissertations

Being a relatively new risk source, models to quantify cyber risks are not well developed; therefore, cyber risk management in most businesses depends on qualitative assessments. With the increase in the economic consequences of cyber incidents, the importance of quantifying cyber risks has increased. Cyber risk quantification is also needed to establish communication among decision-makers of different levels of an enterprise, from technical personnel to top management.

The goal of this research is to build a probabilistic cybersecurity risk analysis model that relates attack propagation with impact propagation through internal dependencies and allows temporal analysis.

The contributions of the developed …

Move: Mobile Observers Variants And Extensions, Ryan Florin

Computer Science Theses & Dissertations

Traffic state estimation is a fundamental task of Intelligent Transportation Systems. Recent advances in sensor technology and emerging computer and vehicular communications paradigms have brought the task of estimating traffic state parameters in real-time within reach.

This has led to the main research question of this thesis: Can a vehicle accurately estimate traffic parameters using onboard resources shared through CV technology in a lightweight manner without utilizing centralized or roadside infrastructure?

In 1954 Wardrop and Charlesworth proposed the Moving Observer method to measure traffic parameters based on an observed number of vehicle passes. We start by proposing methods for detecting …

Feature Extraction And Design In Deep Learning Models, Daniel Perez

Computational Modeling & Simulation Engineering Theses & Dissertations

The selection and computation of meaningful features is critical for developing good deep learning methods. This dissertation demonstrates how focusing on this process can significantly improve the results of learning-based approaches. Specifically, this dissertation presents a series of different studies in which feature extraction and design was a significant factor for obtaining effective results. The first two studies are a content-based image retrieval system (CBIR) and a seagrass quantification study in which deep learning models were used to extract meaningful high-level features that significantly increased the performance of the approaches. Secondly, a method for change detection is proposed where the …

Cybersecurity Risk Assessment Using Graph Theoretical Anomaly Detection And Machine Learning, Goksel Kucukkaya

Engineering Management & Systems Engineering Theses & Dissertations

The cyber domain is a great business enabler providing many types of enterprises new opportunities such as scaling up services, obtaining customer insights, identifying end-user profiles, sharing data, and expanding to new communities. However, the cyber domain also comes with its own set of risks. Cybersecurity risk assessment helps enterprises explore these new opportunities and, at the same time, proportionately manage the risks by establishing cyber situational awareness and identifying potential consequences. Anomaly detection is a mechanism to enable situational awareness in the cyber domain. However, anomaly detection also requires one of the most extensive sets of data and features …

Stability Of Low Crested And Submerged Breakwaters: A Reanalysis And Model Development, Christopher P. Burgess

Civil & Environmental Engineering Theses & Dissertations

Low-crested and submerged structures (LCS) play an integral part in the stabilization of shorelines for recreational purposes, yet there are a plethora of empirical models and gaps in the understanding of their stability and damage progression. The objectives were: i) to evaluate the present formulae, ii) explore variable importance, iii) formulate a stability model, iv) extend the current datasets and v) explore a new model for LCS. The literature points to an increasing understanding of the initiation of damage of LCS and recent exploration of the shear stress-induced erosion (van Rijn, 2019). Assessment of two existing models (Kramer, 2006 and …

A New Method For Estimating The Physical Characteristics Of Martian Dust Devils, Shelly Cahoon Mann

Mechanical & Aerospace Engineering Theses & Dissertations

Critical to the future exploration of Mars is having a detailed understanding of the atmospheric environment and its potential dangers. The dust devil is one of these potential dangers. The transport of dust through saltation is believed to be the driving mechanism responsible for Martian weather patterns. The two primary mechanisms for dust transport are dust storms and dust devils. Dust devils on Mars are a frequent occurrence with one in five so called giant dust devils being large enough to leave scars on the surface that are visible from space. Due to the thin atmosphere, winds of 60 mph …

Predictions Of Knee Joint Contact Forces Using Only Kinematic Inputs With A Recurrent Neural Network, Kaileigh Elisabeth Estler

Human Movement Sciences & Special Education Theses & Dissertations

BACKGROUND: Knee joint contact (bone on bone) forces are commonly estimated using surrogate measures such as external knee adduction moments (with limited success) or musculoskeletal modeling (more successful). Despite its capabilities, modeling is not optimal for clinicians or persons with limited experience and knowledge. Therefore, the purpose of this study was to design a novel prediction method for knee joint contact forces that is equal or more accurate than modeling, yet simplistic in terms of required inputs. METHODS: This study included all six subjects’ (71.3±6.5kg, 1.7±0.1m) data from the opensource “Grand Challenge” datasets (simtk.org) and two subjects from the "CAMS" …

Commissioning & Characterization Of Magnetized Gridded Thermionic Electron Source, Mark Stefani

Electrical & Computer Engineering Theses & Dissertations

Collaborative efforts to design and fabricate a magnetized gridded thermionic electron source have been conducted between Xelera and Jefferson Lab. Commissioning and characterization of an electron gun fabricated by Xelera was performed to benchmark the viability of future electron source designs and capabilities. The work involved simulation, installation, trouble-shooting, modifications of the design, commissioning, characterization, and magnetization of the electron beam produced. A specially designed cavity as well as novel diagnostic tools and methods were developed, implemented, and experimentally tested. Finally, the gun was used to demonstrate a previously unachieved current of magnetized electron beam from a gridded thermionic source …

Spectator Proton Detection And Reconstruction In Deep Inelastic D(E,EpS) Scattering, David Payette

Physics Theses & Dissertations

A Radial Time Projection Chamber (RTPC) was designed and installed in Jefferson Lab's Hall B as part of the BONuS12 (Barely Off-shell Nucleon Structure) experiment. The goal of BONuS12 is to accurately measure the structure function of the neutron by scattering 11 GeV electrons and detecting them with the CLAS12 spectrometer. Deuterium gas was used as an effective neutron target, and the new RTPC was used to detect low- momentum spectator protons. Protons follow a curved path in the 5 Tesla solenoid that is part of CLAS12, ionizing the He-CO2 gas in an annular drift region surrounding the target. These …

Electrostatic Design And Characterization Of A 200 Kev Photogun And Wien Spin Rotator, Gabriel G. Palacios Serrano

Electrical & Computer Engineering Theses & Dissertations

High-energy nuclear physics experiments at the Jefferson Lab Continuous Electron Beam Accelerator Facility (CEBAF) require high spin-polarization electron beams produced from strained super-lattice GaAs photocathodes activated to negative electron affinity in a high voltage photogun operating at 130 kV dc. A pair of Wien filter spin rotators in the injector provides precise control of the electron beam polarization at the end station target. An upgrade of the CEBAF injector to better support the upcoming Moller experiment requires increasing the electron beam energy to 200 keV, resulting in better transmission through injector apertures and improved photocathode lifetime. In addition, the energy …