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An Ultrasensitive Bacterial Detection Platform For Culture-Free Diagnosis Of Infections, Xuyang Shi
An Ultrasensitive Bacterial Detection Platform For Culture-Free Diagnosis Of Infections, Xuyang Shi
ETD Archive
The current methods of the diagnosis of bloodstream infections are based on bacterial culture growth, a process that requires considerable time, e.g., 12-16 hours, to obtain a result. This long wait time for the result creates many problems, including the generation of multi-drug resistant organisms (MDROs). At the same time, infected bloodstream usually contains a very low concentration of bacteria, i.e., lower than 5 CFU/mL. The long diagnosis time and the extremely low concentration of bacteria in the infected bloodstream make such infections difficult to diagnose. Here, we demonstrate a culture-free approach for the diagnosis of bloodstream infections using a …
Serpentine Micromixers Using Extensional Mixing Elements, George Tomaras, Chandrasekhar R. Kothapalli, Petru S. Fodor
Serpentine Micromixers Using Extensional Mixing Elements, George Tomaras, Chandrasekhar R. Kothapalli, Petru S. Fodor
Physics Faculty Publications
Computational fluid dynamics modeling was used to characterize the effect of the integration of constrictions defined by the vertices of hyperbolas on the flow structure in microfluidic serpentine channels. In the new topology, the Dean flows characteristic of the pressure-driven fluid motion along curved channels are combined with elongational flows and asymmetric longitudinal eddies that develop in the constriction region. The resulting complex flow structure is characterized by folding and stretching of the fluid volumes, which can promote enhanced mixing. Optimization of the geometrical parameters defining the constriction region allows for the development of an efficient micromixer topology that shows …