Engineering Commons^™

A Machine Learning Approach For Predicting Clinical Trial Patient Enrollment In Drug Development Portfolio Demand Planning, Ahmed Shoieb

Masters Theses

One of the biggest challenges the clinical research industry currently faces is the accurate forecasting of patient enrollment (namely if and when a clinical trial will achieve full enrollment), as the stochastic behavior of enrollment can significantly contribute to delays in the development of new drugs, increases in duration and costs of clinical trials, and the over- or under- estimation of clinical supply. This study proposes a Machine Learning model using a Fully Convolutional Network (FCN) that is trained on a dataset of 100,000 patient enrollment data points including patient age, patient gender, patient disease, investigational product, study phase, blinded …

Flight Risk Management And Crew Reserve Optimization, Ying Zhang

Doctoral Dissertations

There are two key concerns in the development process of aviation. One is safety, and the other is cost. An airline running with high safety and low cost must be the most competitive one in the market. This work investigates two research efforts respectively relevant to these two concerns.

When building support of a real time Flight Risk Assessment and Mitigation System (FRAMS), a sequential multi-stage approach is developed. The whole risk management process is considered in order to improve the safety of each flight by integrating AHP and FTA technique to describe the framework of all levels of risks …

A Dea Model To Optimize Insurance Payment Plans Based On Pacs, Gagan Rajpal

Doctoral Dissertations

Healthcare industry has evolved dramatically over the time. From being a “cottage industry” to an “organized industry” has brought lot of changes. The changes have been both good and bad. Among the problems that have surfaced in past couple of decades, rising healthcare cost has been one of the most significant. The rising healthcare cost has been documented to be a symptom of several factors. Since the inception of healthcare as an organized industry several payment models for providers and hospitals have been adopted. Current healthcare reforms have proposed new payments models to curb the rising cost and provide consumer …