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Purification Of Artepillin C (Arc) With Anticancer Activities From Supercritical Co2-Ethanol Extracts Of Brazilian Green Propolis By Using Adsorption Column Chromatography, Lin-Hsiang Chuang, Wen-Chin Chen, Wen Pei, Ming-Hsi Chuang, Todd Hsu, Po-Chao Chuang
Purification Of Artepillin C (Arc) With Anticancer Activities From Supercritical Co2-Ethanol Extracts Of Brazilian Green Propolis By Using Adsorption Column Chromatography, Lin-Hsiang Chuang, Wen-Chin Chen, Wen Pei, Ming-Hsi Chuang, Todd Hsu, Po-Chao Chuang
Journal of Marine Science and Technology
Phenolic compounds with varying phenolic structures are present in both terrestrial and marine organisms. Artepillin C (ARC) is a prenylated phenolic compound produced specifically in Brazilian green propolis. Earlier studies have demonstrated the potential of ARC as a dietary supplement for cancer prevention due to its ability to suppress tumor growth and metastasis. Here we report the development of an effective adsorption chromatography combined with supercritical CO2 extraction for the massive purification of ARC. A mixture of supercritical CO2 and ethanol extract of Brazilian green propolis was passed through a stainless chromatographic column packed with protruding metals at 4,000 psi …