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Full-Text Articles in Engineering
Development Of Functional Biomaterials Using Protein Building Blocks, Li-Sheng Wang
Development Of Functional Biomaterials Using Protein Building Blocks, Li-Sheng Wang
Doctoral Dissertations
Proteins have intrinsic molecular properties that are highly useful for materials applications, especially for biomaterials. My research has focused on translating these molecular properties to materials surface behavior. In one approach, I developed a fluorous-based thermal treatment strategy to generate stable thin films from a variety of naturally abundant proteins. The different surface properties generated from the choice of protein were utilized to modulate cell-surface interactions, prevent bacterial adhesions, and control drug loading/release. I have used nanoimprint lithography to generate patterned protein films for cell alignment. Coupling with inkjet printing deposition, I have fabricated mixed protein films with spatial and …
A Multiscale Model Of Protein Adsorption On A Nanoparticle Surface, David Power, Ian Rouse, Stefano Poggio, Erik Brandt, Hender Lopez, Alexander Lyubartsev, Vladimir Lobaskin
A Multiscale Model Of Protein Adsorption On A Nanoparticle Surface, David Power, Ian Rouse, Stefano Poggio, Erik Brandt, Hender Lopez, Alexander Lyubartsev, Vladimir Lobaskin
Articles
We present a methodology to quantify the essential interactions at the interface between inorganic solid nanoparticles (NPs) and biological molecules. Our model is based on pre-calculation of the repetitive contributions to the interaction from molecular segments, which allows us to efficiently scan a multitude of molecules and rank them by their adsorption affinity. The interaction between the biomolecular fragments and the nanomaterial are evaluated using a systematic coarse-graining scheme starting from all-atom molecular dynamics simulations. The NPs are modelled using a two-layer representation, where the outer layer is parameterized at the atomistic level and the core is treated at the …