Open Access. Powered by Scholars. Published by Universities.®
Other Engineering Science and Materials
University of Nebraska - Lincoln
Department of Mechanical and Materials Engineering: Faculty Publications
Articles 1 - 1 of 1
Full-Text Articles in Engineering
Inducing Neurite Outgrowth By Mechanical Cell Stretch, Suzanne Higgins, Jeong Soon Lee, Ligyeom Ha, Jung Yul Lim
Inducing Neurite Outgrowth By Mechanical Cell Stretch, Suzanne Higgins, Jeong Soon Lee, Ligyeom Ha, Jung Yul Lim
Department of Mechanical and Materials Engineering: Faculty Publications
Establishing extracellular milieus to stimulate neuronal regeneration is a critical need in neuronal tissue engineering. Many studies have used a soluble factor (such as nerve growth factor or retinoic acid [RA]), micropatterned substrate, and electrical stimulation to induce enhanced neurogenesis in neuronal precursor cells. However, little attention has been paid to mechanical stimulation because neuronal cells are not generally recognized as being mechanically functional, a characteristic of mechanoresponsive cells such as osteoblasts, chondrocytes, and muscle cells. In this study, we performed proof-of-concept experiments to demonstrate the potential anabolic effects of mechanical stretch to enhance cellular neurogenesis. We cultured human neuroblastoma …