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Amyloid-Beta and Tau; Alzheimer's disease; significant single nucleotide polymorphisms; epigenetic interactions; biomarker; pipeline.
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Identifying Potential Alzheimer’S Disease Biomarkers Beyond Amyloid-Beta And Tau, Frank Cai
Identifying Potential Alzheimer’S Disease Biomarkers Beyond Amyloid-Beta And Tau, Frank Cai
Master's Projects
Alzheimer's Disease (AD) and other forms of Mild Cognitive Impairment (MCI) affect millions of people around the world. The buildup of Amyloid-Beta (Aβ) and Tau proteins in the brain produced by amyloid precursor protein (APP) has been identified as an important cofactor in the onset and progression of AD. However, although patients diagnosed with AD exhibit Aβ and Tau buildup, about 40% of the subjects with Aβ and Tau buildup are not diagnosed with AD. In this project, we hypothesize the involvement of other epigenetic interactions between APP and related genes in addition to the buildup of Aβ and Tau …