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Use Of Exploratory Data-Mining Techniques To Analyze Associations Between Bone-Mineral Density And Relevant Clinical Parameters Of Gaucher Disease, Tingting Fu

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Gaucher disease (GD) is a monogenic disorder with autosomal recessive inheritance, which results from an acid lysosomal hydrolase, the beta-glucocerebrosidase deficiency. Clinical manifestations of the disease include anemia, thrombocytopenia, hepatosplenomegaly, and skeletal complications. Enzyme replacement therapy (ERT) has been used to treat type 1 GD for more than a decade, and many patients have shown remarkable clinical responses to the treatment, with normalization of blood counts, reduction in liver and spleen size, and improvement in bone symptoms. Many researchers have tried to study the effectiveness of ERT, but previous research has been mainly based on some predetermined hypotheses and traditional …