Engineering Commons^™

Prediction Of Growth Factor Effects On Engineered Cartilage Composition Using Deterministic And Stochastic Modeling, Sean S. Kohles, Asit K. Saha, J. (Jagannath) Mazumdar

Mechanical and Materials Engineering Faculty Publications and Presentations

In the design of engineered tissues, guided balance of biomaterial degeneration with tissue synthesis offers refined control of construct development. The objective of this study was to develop a mathematical model that describes the steady state metabolism of extracellular matrix molecules (ECM: glycosaminoglycan and collagen) in an engineered cartilage construct taking into account localized environmental changes that may arise because of the application of growth factors. The variable effects of growth factors were incorporated in the form of random noise rather than the difference in rates of synthesis and catabolism. Thus, the frequency of ECM accumulation for each matrix molecule …

Technology Forecasting Using Data Envelopment Analysis, Oliver Lane Inman

Dissertations and Theses

The ability to anticipate future capabilities of technology products has broad implications for organizations. Technological forecasting allows management to improve resource allocation, make better staffing decisions, and more confidently plan facilities and capital expenditures. Technology forecasting may also identify potential new markets and opportunities, such as finding ways to exploit current technology beyond its originally intended purposes.

Modern technology forecasters use an array of forecasting methods to predict the future performance of a technology, such as time-series analysis, regression, stochastic methods, and simulation. These quantitative methods rely on the assumption that past behavior will continue. Shortcomings include their lack of …