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Development Of Patient Specific Predictive Treatment Margins To Account For Prostate Motion During Treatment Using Real-Time Intra Fraction Tracking, Michael Edward Howard
Development Of Patient Specific Predictive Treatment Margins To Account For Prostate Motion During Treatment Using Real-Time Intra Fraction Tracking, Michael Edward Howard
Doctoral Dissertations
Radiation therapy for prostate cancer has evolved over time. Intra-fractional motion of the prostate has been a clinical limitation in dose delivery. Reduced margins can lead to less toxicity to critical structures and an overall reduction in the risk of secondary cancers. Three models have been developed to predict prostate margins based on the first five fractions of treatment.
An 8th order polynomial model is utilized with the 95% and 99% predictive lines indicating margins. This approach is applied to 24 patients. The maximum values as indicated by the predictive lines are used as the margins for the patient. …