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Nanoparticles For Multimodal In Vivo Imaging In Nanomedicine, Jaehong Key, James F. Leary
Nanoparticles For Multimodal In Vivo Imaging In Nanomedicine, Jaehong Key, James F. Leary
Birck and NCN Publications
While nanoparticles are usually designed for targeted drug delivery, they can also simultaneously provide diagnostic information by a variety of in vivo imaging methods. These diagnostic capabilities make use of specific properties of nanoparticle core materials. Near-infrared fluorescent probes provide optical detection of cells targeted by real-time nanoparticle-distribution studies within the organ compartments of live, anesthetized animals. By combining different imaging modalities, we can start with deep-body imaging by magnetic resonance imaging or computed tomography, and by using optical imaging, get down to the resolution required for real-time fluorescence-guided surgery.