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Fluorescent Biosensors To Measure Endothelial Cell Responses To Fluid Shear Stress, Natalie Noll
Fluorescent Biosensors To Measure Endothelial Cell Responses To Fluid Shear Stress, Natalie Noll
Undergraduate Research Posters
The response of endothelial cells, innermost layer of blood vessels, to blood flow is thought to be critical in the initiation and progression of atherosclerosis. Atherosclerosis in the human body is non-random and is highly correlated to vessel sites which experience oscillatory and reversing blood flow. Endothelial cells (ECs), the inner most cell layer of blood vessels are highly responsive to the drag force from blood flow, known as shear stress. To study endothelial cell responses to shear stress we used a parallel plate flow chamber in which we exposed endothelial cells to defined fluid shear stress. Using fluorescence resonance …