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Molecular, Cellular, and Tissue Engineering
University of Arkansas, Fayetteville
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Role Of Local Renin-Angiotensin System In Potentiating Early Calcific Aortic Valve Disease, Jessica Perez
Role Of Local Renin-Angiotensin System In Potentiating Early Calcific Aortic Valve Disease, Jessica Perez
Graduate Theses and Dissertations
Angiotensin-II (Ang-II), a peptide hormone, is a potent vasoconstrictor and cell mitogen. It has been implicated in the development of hypertension as well as atherosclerosis. Recent work has shown that sclerotic aortic valves possess expression of angiotensin type I receptor (AT-1R) and angiotensin converting enzyme (ACE), suggesting altered angiotensin signaling during disease. The role of altered angiotensin signaling on aortic valve mechanics, however, is not clearly understood. We seek to understand the direct effects of the renin angiotensin signaling (RAS) system on the biological and biomechanical properties of aortic valve tissue and develop a finite constitutive model that mimics the …