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Full-Text Articles in Engineering
Nano-Formulation And Controlled Delivery Of Low Solubility Anticancer Drugs, Anshul Agarwal
Nano-Formulation And Controlled Delivery Of Low Solubility Anticancer Drugs, Anshul Agarwal
Doctoral Dissertations
Optimal drug delivery and reduction of systemic adverse effects have been age old problems in chemotherapeutics in all types of human cancer. During chemotherapy, using water insoluble drugs like paclitaxel and tamoxifen, it has been realized that better formulations are needed for more specific and controlled drug delivery of these agents. In a novel approach to form high content stable nanocolloids of these drugs with controllable release rate, a sonicated layer-by-layer (LbL) polyelectrolyte coating technology is suggested. The desired features of pharmaceutical carriers for intravenous administration include their small size and biodegradability, good loading capacity for a given drug, high …
Preparation Of Nanovehicles For Targeted Drug Delivery, Anagha Avinash Bhakay
Preparation Of Nanovehicles For Targeted Drug Delivery, Anagha Avinash Bhakay
Theses
Application of nanotechnology in pharmaceutical research has opened new frontiers for drug development and its efficient delivery. In recent years, the focus of the research has been on the engineering of nano/micro-particulate structures for efficient and targeted delivery of drugs for selective and enhanced absorption. This work throws light on the preparation of biodegradable and non-toxic nanoparticulate systems for targeted drug delivery. The drug vehicles were made by two different processes namely electrostatic interactions and desolvation process. The drug carriers made by these processes were found to be in the size range of 150-200nm which is necessary for cellular uptake …