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Experimental Determination Of The Agitation Requirements For Solids Suspension In Dissolution Systems Using A Mini Paddle Apparatus, Yang Song
Theses
Dissolution testing is a critical step in quality control of manufactured final products in the pharmaceutical industry. The United State Pharmacopeia (USP) Dissolution Testing Apparatus 2 (paddle) is the most widely used dissolution test devices in the pharmaceutical industry to formulate solid drug dosage forms and to develop quality control specifications for its manufacturing process.
Mini vessels and mini paddle dissolution testing systems are smaller versions of the USP 2 Apparatus. The concept of the mini paddle apparatus is similar to that of the USP 2 setup but it is scaled down about to 1/5 of the volume and 40% …
Experimental Determination Of Solids Suspension With Angled Impeller In A Pharmaceutical Mixing Vessel, Yingxi Tang
Experimental Determination Of Solids Suspension With Angled Impeller In A Pharmaceutical Mixing Vessel, Yingxi Tang
Theses
Angled-mounted impellers are commonly used in a number of pharmaceutical industry applications, from laboratory reactors to full-scale tanks. In these systems, the impeller is not centrally and vertically mounted, as in most stirred vessels, but it enters the vessel, and is therefore immersed in the fluid, at an angle from the vertical. This arrangement provides some baffling effects that would not otherwise exist if the impeller was centrally mounted.
One common requirement for such systems is that they are capable of suspending small solids dispersed in the liquid. Therefore, it is critical to know the value of the minimum agitation …