Engineering Commons^™

Should Expectations About The Rate Of New Antiretroviral Drug Development Impact The Timing Of Hiv Treatment Initiation And Expectations About Treatment Benefits?, Amin Khademi, R. Scott Braithwaite, Denis Saure, Andrew J. Schaefer, Kimberly Nucifora, Mark S. Roberts

Publications

Background: Many analyses of HIV treatment decisions assume a fixed formulary of HIV drugs. However, new drugs are approved nearly twice a year, and the rate of availability of new drugs may affect treatment decisions, particularly when to initiate antiretroviral therapy (ART).

Objectives: To determine the impact of considering the availability of new drugs on the optimal initiation criteria for ART and outcomes in patients with HIV/AIDS.

Methods: We enhanced a previously described simulation model of the optimal time to initiate ART to incorporate the rate of availability of new antiviral drugs. We assumed that the future rate of availability …

Crew Resource Management And Its Possible Role In Nursing Risk Management, I. R. Mcandrew, G. P. Wise

Publications

Crew Resource Management (CRM) was introduced within the aviation industry in the late 1970s after an aircraft ran out of fuel whilst the pilots were trying to solve an undercarriage problem. To reduce such errors and ultimately lower the probability of failure and the severity of risks that occur, training in CRM was rolled out across the whole industry. It has been successful over the last few years in major reductions in the number of crashes and fatalities in the commercial aviation sector. Nursing has similar concerns in that errors can ultimately result in fatalities. There are parallels in the …

Differential Effects Of Refractive Blur On Day And Nighttime Driving Performance, Joanne M. Wood, Michael J. Collins, Alex Chaparro, Ralph Marszalek, Trent Carberry, Philippe Lacherez, Byoung Sun Chu

Publications

PURPOSE. To investigate the effect of different levels of refractive blur on real-world driving performance measured under day and nighttime conditions.

METHODS. Participants included 12 visually normal, young adults (mean age = 25.+- 5.2 years) who drove an instrumented research vehicle around a 4 km closed road circuit with three different levels of binocular spherical refractive blur (+0.50 diopter sphere [DS], +1.00 DS, +2.00 DS) compared with a baseline condition. The subjects wore optimal spherocylinder correction and the additional blur lenses were mounted in modified fullfield goggles; the order of testing of the blur conditions was randomized. Driving …