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Full-Text Articles in Engineering
Biomedical Applications Of Lanthanide Nanomaterials, For Imaging, Sensing And Therapy, Qize Zhang, Stephen O'Brien, Jan Grimm
Biomedical Applications Of Lanthanide Nanomaterials, For Imaging, Sensing And Therapy, Qize Zhang, Stephen O'Brien, Jan Grimm
Publications and Research
The application of nanomaterials made of rare earth elements within biomedical sciences continues to make significant progress. The rare earth elements, also called the lanthanides, play an essential role in modern life through materials and electronics. As we learn more about their utility, function, and underlying physics, we can contemplate extending their applications to biomedicine. This particularly applies to diagnosis and radiation therapy due to their relatively unique features, such as an ultra-wide Stokes shift in the luminescence, variable magnetism and potentially tunable properties, due to the library of lanthanides available and their multivalent oxidation state chemistry. The ability to …
Fabrication And Imaging Characterization Of Poly (Dimethyl Siloxane)/Sic Nano-Fillers Samples As Model Biomaterials, Tetiana Soloviova, Viorica Gutu, Zoya Vinokur, Akm S. Rahman, Subhendra Sarkar
Fabrication And Imaging Characterization Of Poly (Dimethyl Siloxane)/Sic Nano-Fillers Samples As Model Biomaterials, Tetiana Soloviova, Viorica Gutu, Zoya Vinokur, Akm S. Rahman, Subhendra Sarkar
Publications and Research
Biopolymers are being developed with embedded nanostructures for in vivo drug delivery to treat various diseases including cancers. In the current project we developed fabrication steps to prepare two biopolymers, poly di-methoxy siloxane (PDMS) with 0-0.9 vol% of SiC nano whisker (fillers) followed by non- destructive characterization. Optical reflection microscopy (5-100X) was performed to ensure loading and distribution of increasing SiC content. Optical microscopy showed progressively higher SiC distribution as filler loading was increased from 0-0.9 vol%. X-ray imaging at low kV (kilovoltage) and low mAs (milliamperage per second) were optimized to allow distinction between filled PDMS with SiC concentration …
Chelator-Free Radiolabeling Of Serrs Nanoparticles For Whole-Body Pet And Intraoperative Raman Imaging, Matthew A. Wall, Travis Shaffer, Stefan Harmsen, Darjus-Felix Tschaharganeh, Chun-Hao Huang, Scott W. Lowe, Charles Michael Drain, Moritz F. Kircher
Chelator-Free Radiolabeling Of Serrs Nanoparticles For Whole-Body Pet And Intraoperative Raman Imaging, Matthew A. Wall, Travis Shaffer, Stefan Harmsen, Darjus-Felix Tschaharganeh, Chun-Hao Huang, Scott W. Lowe, Charles Michael Drain, Moritz F. Kircher
Publications and Research
A single contrast agent that offers whole-body non-invasive imaging along with the superior sensitivity and spatial resolution of surface-enhanced resonance Raman scattering (SERRS) imaging would allow both pre-operative mapping and intraoperative imaging and thus be highly desirable. We hypothesized that labeling our recently reported ultrabright SERRS nanoparticles with a suitable radiotracer would enable pre-operative identification of regions of interest with whole body imaging that can be rapidly corroborated with a Raman imaging device or handheld Raman scanner in order to provide high precision guidance during surgical procedures. Here we present a straightforward new method that produces radiolabeled SERRS nanoparticles for …